🇲🇫 🪆 IT business analyst + artist before 🦠 #LongCovid : #fibrosis #neuropathy #SFN #MCAS #MRGPRX2 SARS-COV-2 = persistent vascular virus
France
Joined May 2022
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Cerises 🇨🇵 retweeted
I am at a lipid conference at the BSEM in London. I had to share this.
An example of the fatty acid profile (test done by Johns Hopkins) in a long Covid patient.
Cerises 🇨🇵 retweeted
Great to be featured last night on @WCVB along with amazing PolyBio funder & collaborator Steve Pagliuca. We are working hard to validate novel #diagnostic tests and treatments for the millions of patients around the world suffering from Long COVID & Chronic Lyme disease @pagsceltics @JessicaBrownTV wcvb.com/article/former-celt…
Cerises 🇨🇵 retweeted
Sex differences in inflammation, mitochondrial function and energy sensing in early recovery from COVID 19 in older adults. Female post-COVID19 exhib⬆️circulating TNF-α levels & trend toward⬆️ mRNA levels of proinflammatory interleukins IL-1β, IL-18 PBMCs, nature.com/articles/s41598-0…
Cerises 🇨🇵 retweeted
I simply DO NOT understand why people don’t want to know if Covid caused their health issues.
I just don’t get it.
Cerises 🇨🇵 retweeted
"Impaired T-cell and NK cell defences, just like AIDS"
Before Opportunistic Infections (OIs) results in death, the multiple viruses already hiding in the body, are reactivated. #Leonardi_Effect
#LongCOVID is #AirborneAIDS so #WearN95
Konkuk University researchers reviewed evidence that COVID-19 can reactivate dormant herpesviruses, including EBV, CMV and HSV.
Impaired T-cell and NK cell defenses may allow these viruses to reactivate, potentially contributing to Long COVID.
frontiersin.org/journals/imm…
Cerises 🇨🇵 retweeted
🔘🧵1⃣COVID-19 determines a long-lasting NK cell impairment especially in severe patients.
@fitterhappierAJ
frontiersin.org/journals/imm…
Cerises 🇨🇵 retweeted
it may be worth recirculating today too that newly elected Michigan Sen. Abdul El-Sayed authored this 2022 article in The New Republic: "Long Covid Is Just Getting Started. We're Not Ready for It.”
newrepublic.com/article/1654…
Cerises 🇨🇵 retweeted
📈 Le pic épidémique de #Covid19 n'est pas du tout passé : circulation virale dans les eaux usées toujours en forte hausse, dépassant même désormais le pic de l'an dernier à la même période.
Cette hausse est toujours très marquée dans chaque région.
Cerises 🇨🇵 retweeted
France: Viral circulation in wastewater is still rising sharply, even now exceeding last year's peak
📈 Le pic épidémique de #Covid19 n'est pas du tout passé : circulation virale dans les eaux usées toujours en forte hausse, dépassant même désormais le pic de l'an dernier à la même période.
Cette hausse est toujours très marquée dans chaque région.
Cerises 🇨🇵 retweeted
Staphylococcus aureus(1 of the most dangerous bacteria) hide inside human cells and yes, catching COVID triggers overgrowth
C & S. Aureus love story:
Damaged immune systems->Intracellular Staph bacteria face no resistance,rapidly replicate-> causes increased SARS2 replication👍
University of Basel researchers reviewed 33 human studies and found strong evidence that Staphylococcus aureus can hide inside human cells, potentially escaping antibiotics and immune defenses.
thelancet.com/journals/lanmi…
Cerises 🇨🇵 retweeted
Latest paper:
Hypothesis: Myalgic Encephalomyelitis (ME) as a Mast Cell Activation Disorder (MCAD)
preprints.org/manuscript/202…
This is a long paper because I wanted to "set the scene" so to speak and also cover anticipated and valid critiques. A wee summary below 🧵
ALT Infographic explaining the crux of the hypothesis: Pathway from genetic predisposition to dysmetabolism, oxidative stress, inflammation, and mast cell activation. This results in sickness metabolism, driven by interactions between the nervous system, immune system, and metabolism, affecting micronutrients, fat, amino acids, and glucose resulting in sickness behaviour. Mast cell mediators are vast and can cause a range of symptoms, immediately and after some time. Mast cells can be triggered by various things including stress, allergens, cognitive, physical, and emotional exertion. Mast cell activity helps explain: Inconsistencies in research Individual variances ME & PEM triggers Metabolic profile Mixed responses to treatments Importance of pacing (trigger avoidance) Neurological involvement PEM time trends Symptoms
Cerises 🇨🇵 retweeted
BREAKING: A nasal spray significantly reduced brain inflammation in people with progressive multiple sclerosis after 12 weeks in a Phase 2 trial.
Researchers also observed significant improvements in fatigue.
Cerises 🇨🇵 retweeted
🚨 Our new paper on #EDS/HSD, #MCAS and #dysautonomia as risk factors for adverse events and complications: an invited paper. Thanks to my co-authors, Drs. @KSivakoti89360 and Larry Afrin, for their contribution.
tandfonline.com/doi/full/10.…
Cerises 🇨🇵 retweeted
We’re pleased to announce the inaugural PolyBio Convergence Summit will take place this November 18 to 20.
Presentations will explore the latest advances in persistent infections and their emerging roles in conditions such as Long COVID, chronic Lyme disease, multiple sclerosis, Alzheimer’s, and aging. Discussions will focus on the practical challenges that must be addressed to translate these discoveries into validated diagnostics, clinical trials, and effective therapies.
Add the virtual schedule to your calendar here: calendar.google.com/calendar…
Cerises 🇨🇵 retweeted
Persistent viral, bacterial, parasite & other #infections are increasingly implicated in chronic diseases and aging
We’ve united the top scientists, biotech innovators, and other stakeholders working to study & treat these infections into a 3-day Summit.
Come watch the talks virtually at the link below! 👇
We’re pleased to announce the inaugural PolyBio Convergence Summit will take place this November 18 to 20.
Presentations will explore the latest advances in persistent infections and their emerging roles in conditions such as Long COVID, chronic Lyme disease, multiple sclerosis, Alzheimer’s, and aging. Discussions will focus on the practical challenges that must be addressed to translate these discoveries into validated diagnostics, clinical trials, and effective therapies.
Add the virtual schedule to your calendar here: calendar.google.com/calendar…
Cerises 🇨🇵 retweeted
Lying on a vibrating mattress for 40 minutes, combined with taking two pills that release nitric oxide into the body, enhanced the clearance of an Alzheimer's-related protein via the brain's waste-disposal system newscientist.com/article/259…
Cerises 🇨🇵 retweeted
Une pandémie à l’origine de millions de morts et des séquelles chroniques, et un virus qui circule toujours : il est temps de faire du #CovidLong un enjeu de droit.
Soutenons cette proposition de loi portée par la députée Nadège Abomangoli,
J’ai déposé une proposition de loi pour en finir avec l’invisibilisation et l’abandon des malades du Covid long !
Les chiffres sont inquiétants : en 2022, Santé publique France recensait 2 millions de malades, dont 700 000 atteints de formes sévères. Une personne atteinte sur cinq cesse de travailler, et un grand nombre de celles qui poursuivent leur activité ne peuvent reprendre qu’à temps partiel ou finissent par être licenciées. Des jeunes sont radiés de leurs établissements d’enseignement, et les enfants malades restent sans repérage à l’école, faute de formation des médecins scolaires.
Voilà ce que contient ma proposition de loi 👉
Cerises 🇨🇵 retweeted
8 of 12 people with autoimmune disease got a single infusion of CAR-T cells and went into lasting remission - years, no drugs.
With rituximab, the standard way of wiping out B cells, 0 of 15 did. A new preprint argues the gap comes down to one kind of cell - a B cell infected with EBV.🧵
Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab.
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
biorxiv.org/content/10.64898…
