Check out our new paper in @JorSpine that combines mechanical testing, imaging, and compositional analysis to examine the tissues at the vertebra-disc interface in the context of aging and disc degeneration: rduc.me/bFeb @NeilFrings

(4/4) And our newest post-doc, Mengyao, will be presenting findings from her previous work entitled “PRMT5 Deficiency Under Low Se Status Exuberates Cartilage ECM Degradation” at Poster #2331 from 6:15 - 7 PM.

(3/4) Next up, @NeilFrings will be presenting his work on the “Biomechanical, Structural, and Composition Characterization of the Vertebra-disc Interface” at Poster #1591 from 6:15 - 7 PM.

(2/4) Our post-doc, Shengzhi, will be presenting his work titled “A Data-driven Framework for Modulus-density Relationship of Human Lumbar Vertebral Body” at Poster #1680 from 5:30 - 6:15 PM.

Happy Halloween from the SMBL!🎃It's bound tibia good one. - love, the SMBL skeleton

(3/5) Our low-parameter topology-varying optimization approach, “mixed-topology” optimization, can continuously morph between a set of initial scaffold architectures, generating unique designs with microenvironments and mechanical behavior distinct from the original structures.

(2/5) We focus on local, microenvironmental mechanical stimuli that arise from macroscale compression and perfusion, in addition to local surface curvature, that influence cell behavior and can either promote or inhibit osteogenesis.

(1/5) How can cues from the microenvironment inform scaffold design for bone tissue engineering? Check out our new paper “Mechanobiological optimization of scaffolds for bone tissue engineering” in Biomechanics and Modeling in Mechanobiology rdcu.be/dO654 @TimOJosephson

Happy Halloween from the SMBL! 🎃👻🪦

We review how skeletal cells are responsive to a variety of microenvironmental cues, such as strain, fluid shear stress, curvature, & substrate stiffness. These cues can direct the differentiation of marrow stromal cells (MSCs), either promoting or inhibiting osteogenesis. (2/4)