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NIASCEND | Dr. Dmitry Kats

@NIASCEND

Epid @UNCpublichealth | Biostats @usfcoph | Math/CS @XavierU | Biochem @TulaneCBE || 🚀 Ascending beyond just healthy aging mandates https://teapawt.net/t.co/JE2bhVjCml 💎

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pubmed.ncbi.nlm.nih.gov/?term=Kats+Dmitry
Joined October 2023
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND5h
Replying to @AlanaDLevin
Wonder why…
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND5h
Replying to @sharut_gupta @bjing2016 @shuvom_s
That they don’t even realize what tryptophan is for?
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND5h
Replying to @AlanaDLevin
But not this eh?
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND19h
Imagine when AI consistently generates—not some estimate—but the EXACT causal effect of ANY intervention on ANY outcome possible—down to the VERY DAY it happens! By 2020, I already did. We—@OpenAI, @Merck, & I—seek fellow frontierists ready to lead… 🎯 aging-us.com/article/102916/…
🤖 Made with AI
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
NA proves it’s the ONLY NAD choice BY the flush—not balk but SIGN of enough potential energy flux as NAADP through NAD/NADP for excess energy expenditure vs accrual along aging/disease that’s STRONGER than exercise—shaking potential energy out stores—exposing NAM/NMN/NR as futile
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
NA proves it’s the ONLY NAD choice BY the flush—not balk but SIGN of enough potential energy flux as NAADP through NAD/NADP for excess energy expenditure vs accrual along aging/disease that’s STRONGER than exercise—shaking potential energy out stores—exposing NAM/NMN/NR as futile
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDSep 24
Replying to @NIASCEND @j0ssyoursalad
The [anti-inflammatory] flush [which for those more pellagric from the start is far less hostile coming w/ necessary tryptophans to restore tissue niacin binds to—GPR109A—that grew fried away as a result of decades w/o niacin]—remember—is nothing more than a random “side effect”!
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @NakkulYdav13626 @JohnsHopkins @ARPA_H
I would take HOM3OSTASIS.com/NIASCEND seriously—and monogamously Tryptophan-Nicotinic Acid Metabolism in Patients with Tumours of the Bladder and Kidney pmc.ncbi.nlm.nih.gov/article… Cheers!
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
Stalled Franchise (@rizzosarge) profile picture
Stalled Franchise@rizzosargeOct 27
Replying to @TradesByJacob @CaseySapp
Not cures. But many treatments can get you back to a functional human. Have you tried Niacin therapy? Helped me bigtime in 2020 then they wiped @NIASCEND off the social medias
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Marketing amides over nicotinic acid defies logic. NMN, NR, and NAM start behind, choked by deamidation bottlenecks that can never yield or realize high-level NA flux. Paying a premium for amides buys an inherently throttled pathway that fails where direct NA succeeds.
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Mainstream longevity marketing reframed the harmless flush as a structural flaw to push patented, non-flushing amides like NMN & NR, steering public focus away from direct nicotinic acid, locking consumers into fruitless derivative pathways, and hiding the kinetic reality. (1/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Commercial amides hit strict low-capacity NAMPT limits, requiring slow, rate-limited deamidation just to yield free nicotinic acid, meaning they deliver only a weak, metered trickle instead of the uncompromised metabolic surge required for real disease reversal. (2/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
While conventional studies track static, superficial biomarker snapshots, my advanced MCMC-simulated Bayesian joint models of life-course ARIC cohort data—rigorously accounting for non-ignorable attrition—proved uncompromised nicotinic acid flux is completely irreplaceable. (3/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Chronic cellular stress creates an unrelenting metabolic demand for NAD+, rapidly draining and degrading natural tryptophan reserves through inflammatory cascades, leaving cellular engines completely underpowered when patched with dead-end amides. (4/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Achieving complete metabolic restoration requires precise structural pairing: combining direct nicotinic acid with a rare, free-form L- and D-tryptophan fraction where the D-enantiomer acts as a vital kinetic shield against enzymatic degradation. (5/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Direct nicotinic acid instantly surges the Preiss-Handler pathway, driving high-velocity NAD+ to NAADP+ flux while utilizing the temporary physical flush as the definitive boundary marker proving peak endolysosomal potential energy release and homeostatic mastery. (6/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDMay 25
Replying to @dantawfik
Incorrect. ULK1 is totally downstream, subsidiary, just one of many sub proteins dependent on nicotinic acid binding to properly—w/ enough d-tryptophan—modulated GPR109A protein: mdpi.com/1422-0067/21/9/3321 pmc.ncbi.nlm.nih.gov/article… academia.edu/127710430/Nicot… pmc.ncbi.nlm.nih.gov/article…
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDSep 24
Replying to @NIASCEND @j0ssyoursalad
Quantum physical Bayesian MCMC joint multistage causally-inferring modeling at supreme statistical level affirming what top science before it proved—censored after that—such truth remains a relic of the past in favor of deep dives from “Zac Smith”s & Dr. Doolittles, for a reason.
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDMay 30
Replying to @zacsmithfitness
You have seen the medical level 1a evidence for nicotinic acid, right? You do realize it’s the only actual NAD+ precursor, and not any other one like the NR or NMN you are conformed to being limited to. How about boosting GH for obese children for starters pmc.ncbi.nlm.nih.gov/article…
A Pilot Study of the Effects of Niacin Administration on Free Fatty Acid and Growth Hormone...

A Pilot Study of the Effects of Niacin Administration on Free Fatty Acid and Growth Hormone...

Children with obesity have low spontaneous growth hormone (GH) secretion. High circulating Free Fatty Acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults,...

pmc.ncbi.nlm.nih.gov
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Free-form crystalline (immediate release, unaltered, “flush”-inducing) nicotinic acid—specifically—for the niacin/NAD+ side No -mide, NMN, or NR—given their NAD+ synthesis through deamidation to nicotinic acid moiety is rate-limited unlike nicotinic acid nature.com/articles/s41467-0…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDJan 1
Replying to @NIASCEND @jack_schroder_
"Previously, we conducted human clinical trials examining the safety and efficacy of NMN and found that NicAMN levels were significantly increased after NMN administration (62). This result implies that orally administered NMN is degraded to nicotinic acid in humans." cheers
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 27
Replying to @lulopson @GabiHartaiM @VitalikButerin
The number 1 cause of death since humans exist is definitely ignorance.
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HOM3OSTASIS.com (@GPR109A) profile pictureHOM3OSTASIS.com@GPR109A10 Apr 2024
💥 “Only in 1937 was it demonstrated that there was no disease vector but rather a deficiency of nicotinic acid" A Simple Matter of Salt An Ethnography of Nutritional Deficiency in Spain Renate Lellep Fernandez UNIVERSITY OF CALIFORNIA PRESS @GPR109A …
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDJun 29
Replying to @NIASCEND @Tho_ModernMissy @JohnDParody @GPR109A
Boost Your Recovery with Nicotinic Acid: Harnessing the Power of Growth Hormone firstchoiceequine.com/post/b…
Boost Your Recovery with Nicotinic Acid: Harnessing the Power of Growth Hormone

Boost Your Recovery with Nicotinic Acid: Harnessing the Power of Growth Hormone

Introduction: After an intense training session or a grueling race, athletes often seek effective strategies to optimize their recovery process. One promising method gaining attention in the athletic...

firstchoiceequine.com
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDApr 30
Replying to @NIASCEND @Tho_ModernMissy @JohnDParody @GPR109A
Again, nothing to see here .. let's continue to pretend this doesn't exist and instead handwave that peptide consists of a magical signaling & not PELLAGRAGENIC agent The effect of nicotinic acid on growth hormone-induced lipolysis and glucose intolerance translationalres.com/article…

The effect of nicotinic acid on growth hormone-induced lipolysis and glucose intolerance

To assess the role of lipolysis in growth hormone (GH)-induced glucose intolerance, intravenous glucose tolerance tests were carried out in 5 normal volunteers under 4 conditions: (1) control, (2) 4...

translationalres.com
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