
Asst. Professor @Harvardmed and @BrighamAnes
Boston, MA
Joined July 2010
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Nitin Joshi retweeted
Researchers develop “smart” nanoparticles to deliver targeted gene therapy in osteoarthritis.
Read more from @MassGenBrigham @NJoshiBWH and colleagues: massgeneralbrigham.org/en/ab… @NatureNano
Our new paper is out in @NatureNano
We describe a non-viral gene delivery platform that delivers mRNA precisely to damaged cartilage in osteoarthritis and self-regulates targeting and expression as disease severity increases.
nature.com/articles/s41565-0…
massgeneralbrigham.org/en/ab…
Huge congratulations to @DewaniMahima and @jgao_umass for leading this work. Grateful to our collaborators Li Zeng, Anjali Mamidwar, @MrJeffKarp and the rest of the team who made this possible.
Excited about what this means for precision gene therapies in degenerative diseases!
🔥Our latest work is out in PNAS! We report a mechanically resilient hydrogel that enables sustained, localized delivery of therapies for post-traumatic osteoarthritis, without breaking down under physical activities like running! pnas.org/doi/10.1073/pnas.24…
@PNASNews
HUGE thanks to my collaborators @MrJeffKarp
and Joerg Ermann, and congratulations to the entire team for the tremendous work over the years. Thank you
@NIH @NIH_NIAMS @DeptofDefense @NFLPA @RheumResearch for the support.
@MassGenBrigham @BrighamWomens @harvardmed @BrighamAnes
Nitin Joshi retweeted
Blood–brain-barrier-crossing lipid nanoparticles (BLNPs). Wonderful academia and industry collaborations @IcahnMountSinai @biogen @OhioState! Thanks @NIGMS & @NIDAnews! Thanks @NatureMaterials editor and reviewers!
CONGRATULATIONS to my colleagues @IcahnMountSinai for developing lipid nanoparticle system capable of delivering mRNA to brain via intravenous injection, a challenge that has long been limited by protective nature of #BloodBrainBarrier. @NatureMaterials👉 nature.com/articles/s41563-0…
Nitin Joshi retweeted
Rising Stars 2025! @BrianAguado Haogang Cai @JunChenLab @DengYanxiang @mhhettiaratchi @LaurelHind Guosong Hong @priscilla_hwang @NJoshiBWH @IsaacLeeLab Jiahe Li @ClaudiaLoebel @mistrigr @KarinaNakayama @hadi_nia @LabRaghavan @DrRituRaman @telomerase2 @Yichun_Wang_Lab @jaweinst
Check out the press release describing our Pathogen Capture and Neutralizing Spray (PCANS) with potential to prevent a broad range of respiratory infections. @MrJeffKarp @harvardmed @BrighamWomens
news.harvard.edu/gazette/sto…
brighamandwomens.org/about-b…
Nitin Joshi retweeted
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/
Nitin Joshi retweeted
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:
“The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.
“PCANS forms a gel, increasing its mechanical strength by a hundred times, forming a solid barrier,” said primary author John Joseph, PhD, a former postdoctoral fellow at Brigham and Women’s Hospital. “It blocked and neutralized almost 100% of all viruses and bacteria we tested, including Influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more.”
Experiments in mice showed that a single dose of the PCANS nasal spray could effectively block infection from an influenza virus (PR8) at 25 times the lethal dose. Virus levels in the lungs were reduced by >99.99%, and the inflammatory cells and cytokines in the lungs of PCANS-treated animals were normal.”
Nitin Joshi retweeted
In a preclinical study, @NJoshiBWH, @MrJeffKarp and their collaborators have created and tested an innovative drug-free nasal spray that has the potential to be a public health tool in reducing respiratory diseases. buff.ly/3XXwDTm
Thrilled to share our new research in Advanced Materials, describing a Pathogen Capture and Neutralizing Spray (PCANS) with potential to provide extra protection against a broad range of respiratory infections when masks and vaccines fall short. onlinelibrary.wiley.com/doi/…
HUGE congratulations to John Joseph, Helna Mary Baby, Joselyn Rojas Quintero, @MrJeffKarp , Yohannes Tesfaigzi and the rest of the incredible team! Thank you to @steppingstrong1 for the wonderful support! @BrighamWomens @harvardmed @BrighamAnes
New review from our lab discussing "Precision drug delivery to the central nervous system using engineered nanoparticles” in @NatRevMater with @MrJeffKarp. Huge Congratulations to @jgao_umass and the team. nature.com/articles/s41578-0…
@massgeneralbrigham @harvardmed @BrighamWomens
Check out our review article "Gene therapies for CNS diseases: modalities, delivery, and translational challenges" in @NatRevNeurosci Congratulations to @jgao_umass for leading this effort in collaboration with @MrJeffKarp, @RudyTanzi, and @AnaGriciuc. rdcu.be/dLic2
Nitin Joshi retweeted
please join us in welcoming Dr. Jingjing Gao to UMass BME!! Dr. Gao will be joining us as an assistant professor this fall. we are so thrilled to have you!🥳 @JGao66
Huge congratulations Jingjing!! @JGao66. I am really proud of you!!! Looking forward to following all the exciting work from your lab at @UMassAmherst!
Thrilled to announce that I will the BME department at UMass Amherst as an Assistant Professor this Fall! Incredibly grateful to my mentors @MrJeffKarp @NJoshiBWH @UMassThaiGroup for their guidance and support along this journey!! Thank the support from my family as always!














