@NLdeVries

👩‍🔬 Scientist | 🔬 Immunology | 📍Genmab

 Amsterdam, Nederland
Joined December 2017
  • Tweets45
  • Following97
  • Followers83
5Media
Very happy to share with you an amazing piece of work on gamma delta T cells published today in @Nature. Thanks to a huge team effort by @deMirandaLab @NFdeMiranda Emile Voest Frits Koning @MyriamChalabi @jorisvandehaar @vivienveninga from @LUMC_Leiden and @NKI_nl
de Miranda Lab@deMirandaLab11 Jan 2023
It’s finally out! Our most recent work published today in @Nature: γδ T cells are effectors of immunotherapy in cancers with HLA class I defects. nature.com/articles/s41586-0… 🧵below 👇👇👇
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Out today: our news & views in Nat Immunol on the recent (and excellent) Nature paper by Voest & ⁦@NFdeMiranda⁩ teams: nature.com/articles/s41590-0…
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Natasja de Vries retweeted
de Miranda Lab@deMirandaLab13 Feb 2023
Wonderful N&V in @NatImmunol by actual #gdTcell experts @BSilva_Santos and S. Mensurado (thank you!), inspired by our recent work. It's amazing to see the ethusiasm from the #gdTcell community. #cancer #immunotherapy nature.com/articles/s41590-0…
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Natasja de Vries retweeted
ACIR
@ACIR_org8 Feb 2023
SPOTLIGHT:@NLdeVries @jorisvandehaar @vivienveninga @MyriamChalabi demonstrated that γδ T cells contributed to the response to immune checkpoint blockade in patients with β2-microglobulin-negative DNA mismatch repair-deficient colon cancers 👉 ow.ly/9f9w50MN96V
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Natasja de Vries retweeted
Marco Gerlinger@MarcoGerlinger6 Feb 2023
γδ T-cells are effectors in MMRd cancers with B2M loss from Voest lab in Nature nature.com/articles/s41586-0… A hell of a paper - maybe THE paper of 2023, although I am conscious I am sticking my head out saying this in February. Reasons are.... 1/2

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Nature - γδ T cells contribute to the response to immune checkpoint blockade treatment in patients with HLA-class-I-negative DNA mismatch repair-deficient colon cancers. .

nature.com
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This week: A team at @LUMC_Leiden showed that γδ #Tcells can detect cancer cells that are "invisible" to other T cells. @NLdeVries @jorisvandehaar @vivienveninga @MyriamChalabi 📝 go.nature.com/3IGGxRR ▶️ bit.ly/3WX1Ty3
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γδ T cells unveil invisible tumors dlvr.it/Sj2PPV #immunology
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γδ T cells mediate immunotherapy responses when cancers lack MHC class I dlvr.it/ShpS8W
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Natasja de Vries retweeted
Cancer Discovery@CD_AACR20 Jan 2023
Cancer Discovery #ResearchWatch: γδ #TCells Mediate Immunotherapy Response in HLA Class I–Deficient Cancers, summarizing the work of @NLdeVries, @jorisvandehaar, @vivienveninga, @MyriamChalabi, @NFdeMiranda, Emile E. Voest, et al. bit.ly/3XuPEdc @NKI_nl @LUMC_Leiden
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Natasja de Vries retweeted
LUMC Leiden@LUMC_Leiden11 Jan 2023
Wetenschappers van het LUMC en het @hetAVL ontdekten hoe gespecialiseerde #immuuncellen in staat zijn tot het opsporen en verwijderen van #tumoren, die ‘onzichtbaar’ zijn voor de conventionele verdedigingsmechanismen van het #immuunsysteem 👇 @Nature lumc.nl/over-het-lumc/actuee…
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Immune checkpoint blockade responses in HLA class I-negative cancers explained below 👇👇👇
nature
@Nature14 Jan 2023
Nature research paper: γδ T cells are effectors of immunotherapy in cancers with HLA class I defects go.nature.com/3W6V3pl
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New #JITC article: Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry bit.ly/3nIyl85 @NFdeMiranda @NLdeVries
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Natasja de Vries retweeted
Noel F. de Miranda@NFdeMiranda7 Jul 2022
Congrats @NLdeVries and Thomas Brouwer. It was a painstaking work to collect and profile several tissues derived from #PancreaticCancer patients to resolve systemic and local immune profiles. Several leads discovered here will keep the lab busy for years to come!
de Miranda Lab@deMirandaLab7 Jul 2022
The most recent paper from the lab has been published at @jitcancer. We employed single-cell mass cytometry to delineate tumor-associated and systemic immune profiles in #PancreaticCancer. jitc.bmj.com/content/10/7/e0…
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Happy to share our latest paper in @jitcancer with @deMirandaLab: comprehensive analysis of local and systemic immune profiles in patients with PDAC. Our findings encourage further investigation of the role of ILC1-like cells and B cells in PDAC. To read: jitc.bmj.com/content/jitc/10…
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Natasja de Vries retweeted
de Miranda Lab@deMirandaLab7 Jul 2022
The most recent paper from the lab has been published at @jitcancer. We employed single-cell mass cytometry to delineate tumor-associated and systemic immune profiles in #PancreaticCancer. jitc.bmj.com/content/10/7/e0…
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Natasja de Vries retweeted
de Miranda Lab@deMirandaLab16 Oct 2021
Check our pre-print: gd-T cells are effectors of #immune #checkpoint blockade #immunotherapy in #colorectal #cancer. Great collaboration between @deMirandaLab and Voest lab @LUMC_Leiden and @NKI_nl. @NLdeVries @jorisvandehaar @VeningaVivien @MyriamChalabi biorxiv.org/cgi/content/shor…
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gd T cells are effectors of immune checkpoint blockade in MMR-deficient colon cancers with antigen presentation defects: biorxiv.org/content/10.1101/… Great team effort of @deMirandaLab @jorisvandehaar @VeningaVivien #colorectalcancer #gdTcells #immunotherapy #checkpointblockade

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers...

DNA mismatch repair deficient (MMR-d) cancers present an abundance of neoantigens that likely underlies their exceptional responsiveness to immune checkpoint blockade (ICB)[1][1],[2][2]. However,...

biorxiv.org
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I’m happy to share with you our review on the integration of genomic and cytometric approaches to study the cancer microenvironment in detail, now published in @FrontOncology with @ahmedElkoussy @NFdeMiranda @deMirandaLab Frits Koning frontiersin.org/articles/10.…
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Interested in #colorectalcancer #immunology #genomics #immunotherapy? Follow our Immunogenomics Lab @deMirandaLab for our latest research and activities! @LUMC_Leiden
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Natasja de Vries retweeted
de Miranda Lab@deMirandaLab30 Dec 2019
We can find anti-cancer immune responses in #colorectalcancer patients that are currently not considered for #Immunotherapy Congratulations to @JvandenBulk et al. for a lot of work Next step: develop specific approaches for these patients! genomemedicine.biomedcentral… @GenomeMedicine
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