Currently looking for a new role in platelet biology or microscopy. Climber, Baker, Frisbee player. Views my own
Oxford, England
Joined September 2013
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Leica X Science - Meet Nathan Asquith linkedin.com/pulse/leica-x-s…
We are super thankful to @LeicaMicro for the opportunity to share our work! I'm excited to delve deeper and use the AI-powered rare event detection workflow for megakaryocyte and proplatelet events.
Nathan Asquith retweeted
See this #November #coverart article!
@NathanAsquith1 et al. have described an exciting new novel secretory system for loading molecules into platelets for therapeutic purposes.
Platelets are professional secretory cells with a variety of granules and other noncanonical secretory organelles (α-granules, dense granules, lysosomes, and dense tubular system (DTS) ). This work sheds light on the localization and transport of the understudied DTS within MKs and throughout (pro)platelet intermediates.
✍️ @NathanAsquith1 @JosepItaliano @theclotthickens
jthjournal.org/article/S1538…
The new issue of JTH is out! Featuring our new paper and front cover describing the use of dense tubular system for therapeutic protein packaging into platelets. jthjournal.org/article/S1538…
1/4
3/4 An insightful commentary was written by Freda Passam and her lab highlighting the novelties of our work, and interesting paths for future directions! Awesome schematic summarizing our paper too! Check it out here. jthjournal.org/article/S1538…
4/4 I am also really happy that JTH accepted my submission for this month's front cover! In this image megakaryocytes are making elaborate proplatelet networks (cyan) while transporting vWF (magenta). Captured using a @LeicaMicro Stellaris 5.
Happy #fluorescencefriday . My projects in the Shelton lab and @jointbme department are in full swing! I was optimizing some of the imaging settings for one of our projects and made this cool video of our breast cancer cell line. DNA, vWF and actin filaments.
I am excited to share my new publication with @JosepItaliano. This project kickstarted my love for microscopy and one can see how much progress I made over the years from the image below to those in the final paper. Ha! Thanks to my lab mates and mentors for making it happen.
Asquith et al., show that it's possible to target and release therapeutic cargo in megakaryocytes and platelets using a novel secretory system.
@nathanasquith1
@isabellecarlota
@nubama
@tcell_camacho
@danifreirech
@theclotthickens
@JosepItaliano
jthjournal.org/article/S1538…
Nathan Asquith retweeted
Check out this great PhD opportunity 👇
We are offering a great opportunity to undertake a PhD within our laboratories (Duval, Ariëns), see details below (apply before end of July) phd.leeds.ac.uk/project/2012…
Nathan Asquith retweeted
📣 We are excited to announce that our new article on the use of silk-based bioink for bioprinting 3D models of hematopoiesis has been published on Advanced Science...
A new step toward 3D cell culture innovation 📣
...and stay tuned, more is coming...
Nathan Asquith retweeted
We are looking for a PhD student to work on a project on reprogramming megakaryocytes. Ideally w background in cell or platelet biology. Come join our team! Reach out via DM or apply here: bewerbung.unimedizin-mainz.d…
Nathan Asquith retweeted
haematologica.org/article/vi… Our new paper is finally in print. A big congrats to @isabellecarlota for driving this forward. #megakaryocyte
I'm excited to announce that I will join @SarahSheltonPhD in her new lab as a research associate within the joint biomedical engineering program at UNC-NCSU. We will be working on micro physiological systems, and I'm super excited to start using our new Stellaris 5 microscope!
It's really lovely to see the final version out in the wild! I hope it won't take too long to see that printed version. 🤩. It's funny to think that I took that image almost one year and a half ago! I guess time flies when one loves to do microscopy!
Absolutely thrilled to see our work on platelet production out in @BloodJournal today. Congrats to @NathanAsquith1 @ECarminita @AbAttacks ashpublications.org/blood/ar…
Hopefully, our lab will get to share additional beautiful images of megakaryocytes and proplatelets through fluorescence Fridays and another story we have just submitted!. Thanks again to all authors and collaborators for everything! and @ABalduiniLab for their great commentary.
For those interested, here is access to the paper for the next 50 days.
authors.elsevier.com/a/1iS5v…
Megakaryocytes and (Pro)platelets again. It's not as clean as last week! Tried using a different LUT. Still trying to convince Joe to let us try superresolution sometime soon for some of our cytoskeletal projects! DNA 🔵, Tubulin 🟠, CD42b ⚪️. #FluorescenceFriday @zeiss_micro
Megakaryocytes and (Pro)platelets
Had some extra minutes on the confocal, so took this image solely for you folks and #FluorescenceFriday
It's #FluorescenceFriday. The @JosepItaliano lab has a history of researching the transport of organelles and proteins from megakaryocytes to platelets. Here, we are tracking a protein fused with eGFP that we have overexpressed in megakaryocytes. Imaged using @zeiss_micro 880.