@NativeMassSpec

NIH RM1 BTOD Center advancing scientific instrumentation and computational tools in collaboration with biomedical researchers across the nation.

 The Ohio State University, Columbus, OH
nativems.osu.edu
Joined October 2018
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  • Followers497
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Native MS-Guided Structural Biology Center retweeted
Center for Electron Microscopy and Analysis@CEMAS_OSU27 Dec 2023
Join @thermofisher and @NativeMassSpec on January 16 to highlight the complementarity of native mass spectrometry and cryoEM 🎉 To register, visit forms.office.com/Pages/Respo…
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Native MS-Guided Structural Biology Center retweeted
Ryan Kibler@kribler8 Apr 2023
Breaking a big problem into smaller pieces and solving them one by one is a good strategy for designing a protein (and navigating life in general). Check out the @biorxivpreprint where we apply this idea to designing pseudosymmetric hetero-oligomers! biorxiv.org/content/10.1101/…

Stepwise design of pseudosymmetric protein hetero-oligomers

Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such...

biorxiv.org
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Native MS-Guided Structural Biology Center retweeted
Ryan Kibler@kribler8 Apr 2023
In this paper, we pseudosymmetrized two de novo designed homo-oligomers. For the first, BGL0 (pronounced “bagel zero”), we worked worked with @NativeMassSpec and @SibylsSAXS to verify that 10 of the 20 redesigned homotrimers assemble properly
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Webinar: Native Mass Spectrometry for Structural Biology via @ProteinSociety mailchi.mp/proteinsociety/jo…
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Native MS-Guided Structural Biology Center retweeted
Samantha Sarni@SamanthaSarni14 Nov 2022
It's out! Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…

Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrom...

RNA-binding proteins contain intrinsically disordered regions whose functions in RNA recognition are poorly understood. The RNA chaperone Hfq is a ...

pnas.org
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Native MS-Guided Structural Biology Center retweeted
Weicheng Li@WeichengLite5 Oct 2022
Excited to share our latest cooperativity story. We quantified the ligand binding cooperativity in cyclic homo-oligomers via Native MS and mechanistic modeling. One of the proteins has about 30 times higher cooperativity than hemoglobin! @NativeMassSpec @OSU_CBC
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Native MS-Guided Structural Biology Center retweeted
Sophie Harvey@SophsHarvey19 Oct 2022
Excited to work on this collaboration with @BHIVE_Center and @NativeMassSpec
The B-HIVE Center@BHIVE_Center17 Oct 2022
Replying to @BHIVE_Center
Sophie Harvey, PhD @SophsHarvey, Research Scientist @OhioState Univ., Dept. of Chemistry and Biochemistry @OSU_CBC. Dr. Harvey will use native mass spectrometry to characterize the interactions of the HIV-1 capsid protein with small molecule antivirals.
Professional Headshot of Dr. Sophie Harvey

ALT Professional Headshot of Dr. Sophie Harvey

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Native MS-Guided Structural Biology Center retweeted
Ying Ge Research Lab@Ge_Lab_UW12 Aug 2022
Give our new MASH Native page a follow for exciting updates to our FREE MS processing software that can process ALL types of native MS data!
MASH Native@MashNative10 Aug 2022
MASH Native is an expansion of MASH Explorer that now includes spectral summing, internal fragments, and UniDec deconvolution capability.
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Native MS-Guided Structural Biology Center retweeted
Samantha Sarni@SamanthaSarni31 May 2022
I really enjoyed being a part of this collaboration between the @woodson_lab and @NativeMassSpec where we used native MS with IM-SID to better understand the role of intrinsically disordered C-terminal domains in the multimeric RNA-binding protein Hfq. biorxiv.org/content/10.1101/…

Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrom...

RNA-binding proteins contain intrinsically disordered regions whose functions in RNA recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains six flexible C-terminal...

biorxiv.org
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Check out these Resource presentations by the Wysocki group and Russell group at ASMS 2022 nativems.osu.edu/node/505
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Native MS-Guided Structural Biology Center retweeted
Michael Marty@michaeltmarty19 May 2022
Congrats to @KostelicMarius and Jason for their new paper in @J_ASMS! They discovered that PEG coating improve sensitivity of native MS, especially of AAV capsids. Awesome work from the team @ErinBakerNCSU @Aspinwall_UA @J_Ryan33 @henrymsandersg1! pubs.acs.org/doi/full/10.102…

Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry

Abstract. Native mass spectrometry (MS) and charge detection-mass spectrometry (CD-MS) have become versatile tools for characterizing a wide range of prote

pubs.acs.org
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Interested in learning how Native MS can help answer structural biology questions? A two-day short course in Native Mass Spectrometry, to be held June 4-5 at ASMS in Minneapolis, is designed to introduce this growing field to new practitioners. asms.org/conferences/annual-…
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Native MS-Guided Structural Biology Center retweeted
Michael Marty@michaeltmarty7 Apr 2022
New UniDec version 5.0.3 ready to release in the wild. The most interesting new features are the real time deconvolution experimental features (short thread) and the m/z vs. mass plot for CDMS github.com/michaelmarty/UniD…

Release UniDec Version 5.0.3 · michaelmarty/UniDec

Version 5.0.3 UniDec. Please cite Marty et al. Anal. Chem. 2015. DOI: 10.1021/acs.analchem.5b00140 if you use UniDec in publications. Check out a video tutorial: https://www.youtube.com/watch?v=e33...

github.com
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Native MS-Guided Structural Biology Center retweeted
Ying Ge Research Lab@Ge_Lab_UW8 Apr 2022
The MASH Team is excited to announce the first version of MASH Native! MASH Native builds upon previous versions of MASH Explorer but also includes new features such as spectral summing, internal fragments, and Unidec deconvolution. Check it out today at: labs.wisc.edu/gelab/MASH_Exp…
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Protein Quaternary Structures in Solution are a Mixture of Multiple forms biorxiv.org/content/10.1101/…

Protein Quaternary Structures in Solution are a Mixture of Multiple forms

Over half the proteins form homo or hetero-oligomeric structures. Experimentally determined structures are often considered in determining a protein’s oligomeric state, but static structures miss the...

biorxiv.org
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Webinar opportunity: Vicki Wysocki will present "Automating Native Mass Spectrometry Through the Use of Online Buffer Exchange" sponsored by Thermo Fisher Scientific. app.acspubs.org/e/es?s=19136…
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Native MS-Guided Structural Biology Center retweeted
FosterLab@MPFosterLab21 Mar 2022
Replying to @WeichengLite
@WeichengLite from the @MPFosterLab and Andrew Norris from the @WysockiVicki lab and the Resource for @NativeMassSpec @OSU_CBC lead a study to examine how cooperativity drives population shifts in ring-shaped oligomeric proteins. biorxiv.org/cgi/content/shor… #biophysics #allostery
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Application of native MS to understand Salmonella pathogenesis. sciencedirect.com/science/ar…
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Review of recent advances, related techniques, and recent applications of native mass spectrometry to address challenging questions in structural biology. annualreviews.org/doi/10.114…
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Vicki Wysocki announced as incoming Editor-in-Chief of JASMS! @WysockiVicki
Am Soc for Mass Spec@asmsnews17 Feb 2022
We are thrilled to share the news that longtime @asmsnews member, Past President Vicki Wysocki is the incoming @J_ASMS Editor-in-Chief. Her term begins 07-2022. Read full announcement asms.org/publications/journa…
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