Computational Neuroscience; Ariel University @arieluniversity. Former postdoc, @yusterafa at Columbia University, @Segev_Lab ELSC, Hebrew University
Israel
Joined July 2018
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Using the MICrONS mouse visual cortex connectome from @AllenInstitute, we explored how local dendritic spine organization relates to large-scale cortical connectivity.
One of our findings is that longer pyramidal axons form a higher fraction of synapses onto dendritic spines. Moreover, along individual axons, spine targeting increases with distance from the soma.
Great collaboration with @deangeckt, Michael Reimann, @yusterafa, @Segev_Lab.
biorxiv.org/content/10.64898…
Our collaborative paper is preprinted in bioRxiv: Connectivity Logic of Dendritic Spines in Cortex: Increased Inputs and Ensemble Formation biorxiv.org/content/10.64898…
Dendritic shaft constrictions further compartmentalise synaptic inputs, potentially expanding the computational capacity of neurons.
science.org/doi/10.1126/scia…
Very happy our work on a weird new nanoscale morphological feature is out in @ScienceAdvances. Massive effort involving different high resolution microscopy techniques, multiple institutes, & years of work to convince ourselves DENDRITIC NARROWINGS EXIST buff.ly/RlFOR94
Netanel Ofer retweeted
Very happy our work on a weird new nanoscale morphological feature is out in @ScienceAdvances. Massive effort involving different high resolution microscopy techniques, multiple institutes, & years of work to convince ourselves DENDRITIC NARROWINGS EXIST buff.ly/RlFOR94
Netanel Ofer retweeted
🧠🔬🌴Preprint alert on bioRxiv!
How do neurons build the specialized axonal domains to initiate and propagate action potentials? We identified Paralemmin-2 as a membrane-anchored cytoskeletal component of Axon Initial Segments and nodes of Ranvier biorxiv.org/content/10.64898…
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Our paper is now online in Current Biology! Hydra is one of the very few cnidarians adapted to freshwater. Most of the >11,000 known cnidarian species live in the ocean. So how does Hydra deal with the constant osmotic influx of water? authors.elsevier.com/a/1ni9g…
Netanel Ofer retweeted
Nobel Prize winner Ada Yonath sadly passed away today. She was a legend for her pioneering work on figuring out the structure of ribosomes.
“Focus on what you love to do, what you want to know, first of all, or what you want to achieve, or what you want to do. If you want to be a performer, a dancer, it's okay with me, as long as this is really built in, and you can do it well. Courage is very important, but for science, curiosity is not enough, it should come with the courage. Really wish to understand something. If there is no wish like this, and they ask me where will I get the best salary, or I become more famous, or then I have no answer for that.”
Netanel Ofer retweeted
Our article “Control of water excretion in Hydra vulgaris by neural integration” is published in @CurrentBiology sciencedirect.com/science/ar…
Netanel Ofer retweeted
Excited to report new work using ASAP5 to image electrical activity in dendritic spines in vivo, from collaborators Rafa Yuste and Victor Cornejo.
Main result: Single synaptic activation events, detected by ASAP5, do not result in detectable somatic EPSP, but event ensembles do
Our paper "Highly attenuated dendritic propagation of isolated synaptic potentials in vivo", demonstrating that individual synaptic potentials in vivo do not reach the soma, is published in Science Advances: science.org/doi/epdf/10.1126…
Netanel Ofer retweeted
Our paper "Highly attenuated dendritic propagation of isolated synaptic potentials in vivo", demonstrating that individual synaptic potentials in vivo do not reach the soma, is published in Science Advances: science.org/doi/epdf/10.1126…
Netanel Ofer retweeted
Announcing new Dendritic Integration Symposium, online, Dec 10th., focused on human dendrites. great speakers & free registration!! ntc.columbia.edu/dendritic-i…
Netanel Ofer retweeted
1906 Nobel Prize winner Santiago Ramón y Cajal's 'Advice for a Young Investigator' makes important points:
1. The only thing in your power is your preparation
2. Be suspicious of “brilliance”
3. Be appropriately respectful of authority, but no more
4. Balance concentration and relaxation
5. Don’t worry about what it’s good for
6. Favor independence over resources
7. Embrace scientific panglossianism
Netanel Ofer retweeted
Our work comparing the I/O complexity of different neurons is published in PNAS!
We know human neurons are larger than rat neurons, but are they more functionally complex?
pnas.org/doi/10.1073/pnas.25…
With @danielayoeli @DavidBeniaguev Chris de Kock, @mikilon & @Segev_Lab. (1/13)
Netanel Ofer retweeted
Massive synaptic pruning between birth and adulthood: the nervous system gets simpler with age! Two-decade connectomic effort in Lichtman lab @harvard reveals how the order in which motor neurons activate decides which connections survive. @NatureNeuro 👉 nature.com/articles/s41593-0…
Netanel Ofer retweeted
What is the difference between excitatory and inhibitory neurons?
Beyond the obvious difference of neurotransmitter effect on postsynaptic cell, another remarkable difference is the fact that excitatory neurons have lots of spines, while inhibitory neurons have less spines. 1/13
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What can a neuron compute?
Real biological neurons are complex, but how capable are they?
Using a new method, we found that a single cortical neuron can classify cats vs dogs, recognize spoken words, and solve 10-bit parity, all tasks thought to require entire networks. (1/15)
Netanel Ofer retweeted
Our collaborative paper is preprinted in bioRxiv: Connectivity Logic of Dendritic Spines in Cortex: Increased Inputs and Ensemble Formation biorxiv.org/content/10.64898…
Netanel Ofer retweeted
Excited to announce a powerful new one-two punch for voltage imaging from our lab and collaborators! In two new preprints, we introduce ASAP6c for high-throughput population spike-recording, and ASAP7yfor deep, subthreshold 2P imaging.
🧵 1/14
Netanel Ofer retweeted
#JNeurosci: Beniaguev et al. developed a simplified spiking neuron model: the filter-and-fire (F&F), which showed two key functional consequences of multiple synaptic contacts: increased memorization capacity and spatiotemporal pattern recognition.
doi.org/10.1523/JNEUROSCI.08…
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Preprint out arguing that we should build the techology to translate (compile) molecularly annotated connectomes into dynamics. I think this is incredibly important. arxiv.org/abs/2603.25713
Netanel Ofer retweeted
Our paper "Neuronal ensembles in cortical function and disease" is published in Physiological Reviews | American Physiological Society journals.physiology.org/doi/…
