Origin Genomics retweeted
“I think that if you have a technology that can be proven to be safe, and it can help hundreds of millions of people that suffer from these diseases, it is unethical to not pursue this research,” @CathyTie, founder of @OriginGenomics, told @NPR. #CRISPR #GeneEditing #Bioethics geneticliteracyproject.org/2…
Origin Genomics retweeted
The choice shouldn't just be eliminating embryos with BRCA mutations or keeping BRCA in your lineage. What if you can safely correct it in the embryos with the BRCA mutation and use the original embryos, while also eliminating BRCA mutations in your lineage?
That would give families more chances of having a healthy pregnancy for a child without BRCA mutations. Or if they desire to have multiple children, having more embryos available to them gives them that choice too.
That's what we are working on at Origin Genomics. We actually just announced our preliminary data on using prime editing to correct a pathogenic BRCA1 mutation in a human cell line.
@sarah_jacoby
Origin Genomics retweeted
Recent article on TODAY highlights the current challenges of whether or not to screen for breast cancer causing mutations in embryos.
Currently families have to choose between implanting an embryo with a known breast cancer causing mutation, or discard that embryo altogether.
Our mission at Origin Genomics is to give families the choice to genetically correct that mutation in the embryo and implant that embryo, instead of discarding it, or knowingly implanting an embryo with a breast cancer causing mutation.
Origin Genomics retweeted
How close are we to making human embryo gene editing a reality?
In my Trends in Genetics/Cell Press paper, “Therapeutic germline gene editing” I discuss the scientific progress, ethical considerations, and regulatory path for using embryo gene editing to prevent suffering.
Origin Genomics retweeted
Sharing my full Grand Rounds presentation at Lenox Hill Hospital on the scientific rationale, clinical applications, and future of therapeutic germline gene editing
youtube.com/watch?v=G3zQyN8s…
Origin Genomics retweeted
Great line here from Cathy Tie in the Guardian about how germline gene correction, limited to correcting terminal or debilitating conditions, upholds the sanctity of human life.
1. Our IRB-approved research is intended to study the safety of germline gene editors and help create safe germline gene therapy frameworks in the future.
2. 95% of monogenic diseases have no FDA-approved cures, there are millions of real families suffering from passing down genetic diseases to their children.
3. Parents constantly make decisions for their children's health, that is the standard in bioethics. All medication, like gene therapies (e.g. Baby KJ's case) that are given to newborns or infants are consented under this framework.
4. Safe germline gene correction offers the possibility of preventing the passing down of severe genetic diseases generation after generation, that's what makes it highly effective. Thus, more research should be done on its safety and efficacy as we charter into this medical frontier.
#bioethics
Origin Genomics retweeted
Genetic surgery to correct damaged embryos is something that could be life-changing (and life-creating) for some parents struggling to have children. The technology is here to do this. It's time to have the hard conversations on how to do this safely and ethically. I encourage people to listen to the debate Cathy mentions here, see thehastingscenter.org/news/s…
For the past year, I have been the subject of multiple biotech media takedowns and hit pieces. I kept my composure through all of it.
But recently, a different line was crossed when I was mentioned in the same article as a keynote speaker at the world’s largest gene and cell therapy conference (@ASGCTherapy), who proceeded to speak and act in a way that is not only unprofessional towards me, but compromising to the American public.
Her words and actions deserve serious scrutiny and accountability. Not for me, or the scientists and entrepreneurs in this field, but for the patients left with no options for their genetic diseases.
This is why I penned an open letter to the Board of Directors at ASGCT.
Origin Genomics retweeted
For the past year, I have been the subject of multiple biotech media takedowns and hit pieces. I kept my composure through all of it.
But recently, a different line was crossed when I was mentioned in the same article as a keynote speaker at the world’s largest gene and cell therapy conference (@ASGCTherapy), who proceeded to speak and act in a way that is not only unprofessional towards me, but compromising to the American public.
Her words and actions deserve serious scrutiny and accountability. Not for me, or the scientists and entrepreneurs in this field, but for the patients left with no options for their genetic diseases.
This is why I penned an open letter to the Board of Directors at ASGCT.
Origin Genomics retweeted
Sharing for the first time, our research plan: Human embryonic gene editing to correct disease-causing mutations and prevent heritable disease.
All research conducted with IRB oversight in the United States. Transparency is core to how we operate at @OriginGenomics.
Origin Genomics retweeted
Germline gene correction will happen.
The focus now is doing it with precision, rigor, and clear ethical guardrails.
That’s what we’re building at @OriginGenomics.
@CathyTie has launched @OriginGenomics in New York to advance responsible germline gene correction for severe inherited diseases under IRB oversight. Following the conclusion of Manhattan Genomics, the company aims to push precision genome editing forward and explore MRT in the U.S., pending legislative approval, while keeping ethics and regulatory compliance at the center of genomic medicine.
biospace.com/press-releases/…
Subscribe to our newsletter and get the biggest biotech news straight to your inbox 🧬. syntheticbiologysummit.com/s…
Origin Genomics retweeted
Event from our partner, @hastingscenter
"The Embryo Frontier: Editing Human Life"
@CathyTie @OriginGenomics
@CohenProf & @VarditRavitsky Ravitsky.
More info: elsihub.org/event/embryo-fro…
Origin Genomics retweeted
Q&A: Cathy Tie is back with a new embryo editing startup after shutting down her last, doubling down on one of biotech’s most controversial frontiers. endpoints.news/qa-controvers…
Origin Genomics retweeted
Origin Genomics launches in the U.S. to study precision germline gene correction for severe inherited diseases under IRB oversight.
Read more: itmatterss.in/global/origin-…
#OriginGenomics #GeneEditing #Biotech
@OriginGenomics
Origin Genomics retweeted
It's no secret that I hold vastly different opinions than the current mainstream bioethics field on the use of germline gene editing.
"Should gene editing be applied to embryos that are predisposed to cancers, alzheimer's, heart disease? or limit its use to only homozygous early onset death diseases?"
"If a couple has embryos with genetic mutations, should they adopt children instead or seek germline gene therapy to correct the mutations in their existing embryos?"
The answers to me are clear. Hosted by @hastingscenter and @carnegiecouncil, I will be debating the Deputy Dean of Harvard Law School, I. Glenn Cohen, on the ethics of germline gene editing.
Register for the free livestream here: thehastingscenter.org/callah…
Origin Genomics retweeted
Join us virtually on 4/23 for our Annual Daniel Callahan Program. We will have a lively debate...Should we edit human #embryos to prevent disease—or does it go too far? This timely subject tackles the science, ethics, and future of #GeneEditing ⚖️
🔗: bit.ly/47LdOXR
