@Orr_Lab

Orr Lab at WashU | PI: Miranda Orr, PhD | Lab Interests: Aging, Alzheimer's disease, Neurodegenerative disorders, Tau, and Senescence

 St. Louis, MO
orr-lab.com/
Joined April 2021
  • Tweets70
  • Following103
  • Followers270
4Media
Congratulations to the 10 Goodes Prize winners who along with the ADDF have shaped the last decade of #Alzheimers research around the #biologyofaging, moving the field closer to treating the disease with #precisionmedicine. Hope is here. bit.ly/3B9HPTG
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NanoString is excited to announce it will be acquired by Bruker Corporation in a $392.6 million agreement. We are grateful for our dedicated employees and customers! #futurelooksbright! bit.ly/3vMCkbz
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Thank you @TheADDF for bringing together at#ADPD2024 this impactful roundtable on Novel Approches in AD Research guided by the Biology of Aging with @MiiaKivipelto @jacques_touchon @a_hfillit Miranda Orr @WakeForest @DrJeffCummings – at Oeiras, Portugal
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TO ALL #spatial #genomics CEOs! Please read our Comment ⁦⁦@GENbio⁩ “Sounding an Alarm over Spatial Biology” Scientists’ call for action. We are all part one community and have to act accordingly. Don’t let financial interests ruin innovation. genengnews.com/topics/bioper…

Sounding an Alarm over Spatial Biology

Researchers from across the globe highlight spatial biology’s triumphs and legal trials while issuing an urgent call for antitrust action.

genengnews.com
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.⁦@nanostringtech⁩ is here to stay! Joe Beechem speaks up ⁦@GENbio⁩: “We are not going anywhere”. Only #diversity will drive #innovation in Spatial Genomics! #youarenotalone genengnews.com/topics/omics/…

NanoString CSO Joe Beechem Insists the Company "Not Going Anywhere"

GEN talks to Joe Beechem about the decision to file Chapter 11, where the company goes from here, and the future of innovation in the spatial biology field.

genengnews.com
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I'm curio-s, it may be time to parse on 10x?
Genomix Kid@GenomixKid5 Dec 2023
Hot damn!! 10X is suing everyone in spatial and single cell. I was googling for the latest in Curio...
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It has been fun working with @RCFNeuro, @alzassociation, @CurePSP and other organizers to develop the scientific program for #Tau2024! My lab will be there - will yours? March 25-26, 2024 in Washington, DC. Register now: alz.org/Tau

Tau Global Conference | Alzheimer’s Association

Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.

alz.org
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Happy to share our latest publication - we used spatial proteomics to compare #PART and #AD looking at differences between NFTs, normal neurons and their microenvironments in the CA1 and CA2 subregions of the #hippocampus, as well as the entorhinal cortex. doi.org/10.1002/alz.13484

Spatial proteomics of hippocampal subfield‐specific pathology in Alzheimer's disease and primary...

INTRODUCTION Alzheimer's disease (AD) and primary age-related tauopathy (PART) both harbor 3R/4R hyperphosphorylated-tau (p-tau)-positive neurofibrillary tangles (NFTs) but differ in the spatial...

alz-journals.onlinelibrary.wiley.com
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🧟 The @Orr_Lab is researching senescent cells and their impact on memory problems. Could targeting "zombie" cells be a breakthrough in #Alzheimers treatments? Learn more: brnw.ch/21wD7Hq
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ADDF-funded @Orr_Lab's #CombinationTherapy clinical trial on senescent cells supports the ADDF's core belief that the next generation of #Alzheimers drugs will be guided by #novel targets based on the #BiologyOfAging. More on the trial in @mcknightsltcn: bit.ly/3rgc2Mq
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Last week's 9th Annual Melvin R. Goodes Prize Luncheon & symposium reflected on recent breakthroughs in #Alzheimers research. This year, the ADDF honored DxA-funded scientist, Dr. Rhoda Au for her work with #DigitalBiomarkers and #diagnostics for early Alzheimer's detection.
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First feasibility study of orally-delivered #senolytic therapy in #Alzheimersdisease reports favorable safety data and penetrance of #dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers @wakeforestmed @MitziMGonzales @Orr_Lab nature.com/articles/s41591-0…

Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

Nature Medicine - The first feasibility study of orally delivered senolytic therapy in Alzheimer’s disease reports favorable safety data and penetrance of dasatinib into the brain with a...

nature.com
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Research from @Orr_Lab shows that treatment to clear #senescent cells in #Alzheimer’s disease is safe in Phase I clinical trial. Learn more about the study, which appears in @NatureMedicine. @TheADDF @nanostringtech  brnw.ch/21wCn5E
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Results from a new study led by ADDF-funded @Orr_Lab further validate that novel approaches to #Alzheimers centered around the biology of aging will guide the next generation of therapeutics. Read our statement on the senescent cell treatment study here: bit.ly/3RdEQjd
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A fun day 1 at #AAIC23 with @theREALaivisaur @bbonakda @MaggieFlanagan @Orr_Lab @JohnCraryMDPHD ☺️🧠🍨
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Thank you to all who joined the NSC Directors Symposium at #AGE2023! The session featured presentations from pilot grantees George Sutphin @senmorteco, Miranda Orr @Orr_Lab, Andrey Parkhitko, Anna @ThalackerMercer, Danielle Bruns, @SimoneSidoli, @MariaMMihaylova, & @CristalM_Hill
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More than 6.7M Americans and 57M people worldwide are living with #Alzheimers today. A new gift from the #Lauders ensures the #ADDF will be able to continue funding the most promising science around the globe until we defeat this disease: bit.ly/3G3gNNG
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Within the next 15 years, ADDF will help bring to market a new generation of drugs based on the #biologyofaging that can be combined with other therapies, including anti-amyloids, to defeat #Alzheimers thanks to a historic gift from the #Lauder family: bit.ly/3G3gNNG
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The ADDF is tremendously grateful to our Co-Founders #LeonardLauder & @lauder_ronald, along with the entire 3rd generation of their family – #WilliamLauder, #GaryLauder, @AERIN Lauder Zinterhofer, and #JaneLauder – whose historic gift will help us stop #Alzheimers in its tracks.
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Bruce Willis has been diagnosed with FTD, the actor’s family said in a statement released today. Willis retired from acting in March 2022 due to aphasia, but the family has shared that his symptoms have progressed. Learn more: bit.ly/3YWTsnH
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