PhD | IBD, Microbiome, Precision Medicine opinions my own
Ottawa, Ontario
Joined April 2012
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Our publication characterizing microbiome composition, protein, and metabolite variability during resistant starch fermentation is now in full print @Nature_NPJ
nature.com/articles/s41522-0…
Highlights below:
Beyond these highlights, we found marked variation in SCFA responses and bacterial protein profiles.
We propose that matching the "best" RS to an #IBD patient microbiome may require a personalization assay, which our ex vivo platform is fit for purpose.
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Happy to announce the first chapter of my PhD is published open access in @Nature_NPJ: nature.com/articles/s41522-0… 🧵
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Our new paper adds:
- RS-specific fermentation profiles
- Microbiomes from kids with IBD ferment RS with high inter-individual variability
- Broad microbiome functions are activated by RS, beyond butyrate (nucleic acids, fatty acids, amino acids, and derivatives)
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Peter Dobranowski retweeted
Writing this made me feel better this week. I hope reading it makes you feel better.
theintrinsicperspective.com/…
2025 @NEJM study by @bruce_sands1 et al reports efficacy and safety of anti-TL1A (Tulisokibart) in moderate-severe #UC. Notably, they evaluated patient stratification using a gene-variant machine learning algorithm.
nejm.org/doi/full/10.1056/NE…
Clinical remission was more likely in “predicted responders” (32%) than non-stratified patients (26%). But, clinical remission was also more likely in “predicted responders” randomized to the placebo group (11%) than non-stratified placebo patients (1%).
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