Pediatric Hematology Oncology Journal retweeted
Soon, radiology residents will replace radiology AI models.
Pedrini et al (2026) looked at 3 months' worth of CT scans (2,153) interpreted by an on-call resident. 15.4% of them had intracranial hemorrhage (ICH).
The residents had a sensitivity of 96.4% and specificity of 99.6%. The same studies were given to directly to a commercial AI software, which generated heatmaps. The results and heatmaps were separately evaluated as part of the research protocol (aka not available at interpretation time) with sensitivity of 84% and specificity of 94.4%. Performance by AI improved with multiple hemorrhagic types or sites, but did not outperform the resident.
Of 12 FN reports by residents, 6 would have been caught by the model; the attending that overread the preliminary report obviously found all 12.
AI mislabeled 101 cases as FP for ICH. If these were autonomously read, this would have likely led to increased length of stay, follow-up imaging, or inappropriate treatment changes, including discontinuation or non-administration of thrombolytic therapy in patients with ischemia.
The study authors note that the AI FP "typically would not cause confusion with ICH for radiologists interpreting CT scans, as they are easily recognized as various hyperdense intracranial abnormalities not related to ICH."
Take-home points: 1) Clinical deployment studies are increasingly important for medical AI. The commercial model used here was good and well-validated. 2) Perhaps you should hire a Swiss radiology resident to read all your ICH cases, they seem pretty good.
link.springer.com/article/10…
Pediatric Hematology Oncology Journal retweeted
Replying to @kidzcancerdoc
@kidzcancerdoc amazing to think this was only 15 years ago, how awareness is changing in India, but there are now gaps to fill in support for physicians, especially in smaller centers... #childhoodcancer #India #mapping #icci #cankids #pediatriconcology
Pediatric Hematology Oncology Journal retweeted
#ScienceSaturday
❓ What controls whether T cells keep fighting or get tired?
➡️ A recent study in Nature Immunology reveals that a protein called SATB1 acts like a “brake” on CD8 T cells, the immune system’s cancer-fighting soldiers.
➡️ During chronic infections or #cancer, T cells can become exhausted over time. This research shows that SATB1 controls how fast T cells multiply and how strongly they attack tumors. When SATB1 levels are high, T cells stay balanced but may hold back their attack. When SATB1 is removed, T cells expand faster and fight harder, especially when combined with immunotherapy, though they may tire sooner.
➡️ Importantly, blocking #SATB1 improved tumor control and boosted the power of checkpoint inhibitors in preclinical models, suggesting a promising new strategy to enhance cancer immunotherapy.
🌟 Congratulations to the study authors at the University of Melbourne, Peter Doherty Institute, University Hospital Bonn, Peter MacCallum Cancer Center, and collaborators for deepening our understanding of T cell biology and uncovering a potential way to make immunotherapies even more effective. @UniMelb @TheDohertyInst @UniklinikBonn @PeterMacCC @NaturePortfolio
🔗 Read more: doi.org/10.1038/s41590-025-0…
Pediatric Hematology Oncology Journal retweeted
Replying to @Cancer_Cell
An interesting insight as to how bone mets stay protected!
Pediatric Hematology Oncology Journal retweeted
CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases dlvr.it/TNjd8P
Pediatric Hematology Oncology Journal retweeted
Hypogamma after CART or bispecifics needs aggressive IgG replacement.
A 52-year-old man with a history of splenectomy and hypogammaglobulinemia after CAR T-cell therapy for lymphoma 3 years earlier was admitted with septic shock. Encapsulated diplococci were seen in 20% of neutrophils.
Read the full case details in the Images in Clinical Medicine article “Pneumococcal Sepsis in a Patient with Asplenia and Hypogammaglobulinemia,” from @RushUniversity: nej.md/4oap9GL
Pediatric Hematology Oncology Journal retweeted
For our focus issue on innate immunity, Ruochan Chen, Daolin Tang and colleagues discuss damage-associated molecular pattern (DAMP) release upon cell death and downstream immune pathways. dlvr.it/TNjpPs
Pediatric Hematology Oncology Journal retweeted
New #JITC article: O-GlcNAc transferase promotes immune evasion and immunotherapy resistance in uterine corpus endometrial cancer by targeting the glucocorticoid receptor bit.ly/438LM6i
Pediatric Hematology Oncology Journal retweeted
S-Palmitoylation regulates signaling mediated by NLRP3 and other innate immune receptors dlvr.it/TNjvpf
Pediatric Hematology Oncology Journal retweeted
Researchers in Science have uncovered a surprising role for cholesterol regulation in immune cells. By controlling T cell signaling, the cholesterol transporter protein Aster-A not only shapes immune responses but also influences how the body absorbs fat—protecting mice from obesity.
📄: scim.ag/3KHTk9Z
#SciencePerspective: scim.ag/4olgpOe
Pediatric Hematology Oncology Journal retweeted
Have you encountered plasmablastic lymphoma in childhood, and how would you manage it? sciencedirect.com/science/ar… #nonhodgkinlymphoma #childhoodcancer @kidzcancerdoc @ArjunKachhwaha
Pediatric Hematology Oncology Journal retweeted
Blinatumomab is horribly expensive but it is being used effectively in India! Read more about it!! #blinatumomab #acute_leukemia_refractory #PHOJournal @GAURAVKHARYA @kidzcancerdoc sciencedirect.com/science/ar…
Pediatric Hematology Oncology Journal retweeted
What is the impact on education and employment in patients with thalassemia? See the new study! #thalassemia #phoj #Punjab sciencedirect.com/science/ar…
Pediatric Hematology Oncology Journal retweeted
Replying to @DrGauravNarula @LancetRH_SEAsia @TataMemorial @pho_india @INPHOG @WorldSIOP @oncodaily @AsiaSiop @PrashantTembha1 @PHOJournal @youngsiop @COGorg @ALL_Hub_
Proved:
- Together we can!
- Standardized MRD & Genetics across 🇮🇳
- Improved outcomes significantly over historical data
- Launchpad for #ICiCLe2014 RCT from 2018-22
- Center-wise variability a concern
- Improvements in RCT $ ISCALL @ICMRDELHI
@venkymd @PrashantTembha1
Pediatric Hematology Oncology Journal retweeted
Neuroblastoma (NB) in adolescents: out of all cases of NB, does this account for 20%, 5% or <1% of cases? And is long-term survival better in teen NB patients or <18mo age? doi.org/10.1016/j.phoj.2024.… #neuroblastoma #SouthAfrica #ayacancer #LMIC @PHOJournal @jaquesvhsb @kidzcancerdoc
Pediatric Hematology Oncology Journal retweeted
In Ewing Sarcoma with solitary isolated pulmonary relapse, is pulmonary metastectomy of benefit? doi.org/10.1016/j.phoj.2024.… #metastases #sarcoma #pediatriccancer @PHOJournal @kidzcancerdoc @TimothyLautz
Pediatric Hematology Oncology Journal retweeted
For pediatric mature B-cell non hodgkin lymphoma in India, is event-free survival at 1.5 years 65%, 55% or 45%? Is survival improved with LMB/BFM protocols compared to MCP-842? doi.org/10.1016/j.phoj.2024.… #lymphoma #pediatriccancer #LMIC @PHOJournal @kidzcancerdoc @DrNirmalyaRay
Pediatric Hematology Oncology Journal retweeted
The next time you encounter an apparently well teenager with unexplained high ferritin levels, do a careful eye exam! An interesting case from Greece... doi.org/10.1016/j.phoj.2024.… #hyperferritenemia #cataracts #RareDisease @PHOJournal @kidzcancerdoc
Pediatric Hematology Oncology Journal retweeted
Screening >7000 pregnancies for thalassemia in Delhi! Did the Mentzer index distinguish iron deficiency from thalassemia trait? And was the commonest mutation CD41/42 -TTCT, CD8/9+G or IVS1-5 G>A? doi.org/10.1016/j.phoj.2025.… #thalassemia #screening @PHOJournal @kidzcancerdoc
Pediatric Hematology Oncology Journal retweeted
A new study published in @Haematologica found that the management of CAR T-cell therapy complications showed significant variability across European centers, highlighting a need for standardized treatment guidelines. 📝
More news: lymphoblastic-hub.com
#ALL #MedNews #MedEd



















