Sleep science, subtweets, random photos of dogs or plants. All tweets are posted by Heinrich.
Davis, CA
Joined December 2017
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Anaclet_Gompf_Research retweeted
An excellent long article in @ScienceMagazine about our speech brain-computer interface work and the growing industry efforts to bring this to many more patients:
sciencenews.org/article/brai…
Anaclet_Gompf_Research retweeted
1/ We discovered something totally unexpected about the neural structure of consciousness that overturns decades of thinking on its biological basis and brings us significantly closer to the recipe for generating conscious awareness.
New preprint: biorxiv.org/content/10.64898… (led by @HesseJanis, with @FrankLanfranchi, @_conor_mcgrory, @Yuelin_Shi, and @EngelTatiana)
Anaclet_Gompf_Research retweeted
How does the cortex help regulate sleep & wakefulness? Researchers have ID'ed a sparse population of inhibitory neurons with unusually long axons which increase synchronization across multiple neocortical regions & promote sleep: bit.ly/47TH91Y #FluorescenceFriday
Anaclet_Gompf_Research retweeted
Sustained Activation of a Defensive Behavior-related Circuit Elicits a distinct Homeostatic Sleep Response. BioRxiv.org/content/10.64898…
Might need to go back to see if we have video of our PZ Vglut2 chemogenetic stimulation mice walking backwards! Looks close enough to have some of the injections spill over in this area.
A brainstem module for backward locomotion reveals direction-selective premotor circuits: Neuron cell.com/neuron/fulltext/S08…
Sleep-dependent microglial functions in Alzheimer’s disease
sciencedirect.com/science/ar…
Longitudinal associations of rapid eye movement (REM) sleep and slow-wave sleep with plasma Alzheimer's disease biomarkers
alz-journals.onlinelibrary.w…
Anaclet_Gompf_Research retweeted
Thanks to everyone sharing in this moment!
I’m so grateful to my trainees & collaborators…
dlab.stanford.edu/group-memb…
(pic: optogenetics conference chairs, Tuscany)
Reading for all those asking:
for technical details: dlab.stanford.edu
for everyone: deisseroth.org/projections
Anaclet_Gompf_Research retweeted
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
We usually collect a couple of 5 gallon buckets worth (~25% of them are still pretty good after falling out) to make our own sauce. This one is a really big pile!
Anaclet_Gompf_Research retweeted
Tonight we honor the recipient of the 2026 #HarvardMedicalSchool Division of #SleepMedicine Prize, Dr. Maiken Nedergaard, Prof. of Neurology, Neurosurgery, Pharmacology and Physiology at the @UofR
Nice. This is what David Holtzman has been teasing / talking about for a while...
Online now: Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy dlvr.it/TVhgHL
Anaclet_Gompf_Research retweeted
Twenty years ago, on this day in 2006, Allen Institute for Brain Science announced the completion of our inaugural project: a web-based, 3D map of gene expression in the mouse brain providing scientists with a level of data previously not available. #openscience
Anaclet_Gompf_Research retweeted
For those just starting at @ucdavis or for those who are here and not aware of this - the UC Davis Putah Creek Riparian Preserve is a true treasure - beautiful, serene, filled with amazing plants and animals and other organisms and just spectacular.
Anaclet_Gompf_Research retweeted
"With all the advances in both the science of aging and [#AI], we are in a propitious position to accurately and precisely determine who is at high risk of developing #AlzheimersDisease years before signs of even mild cognitive deficit," writes @EricTopol in a #ScienceExpertVoices article.
Learn more on #WorldAlzheimersDay: scim.ag/3IexVUX
ALT "... there has never been a greater opportunity to identify individuals at high risk for Alzheimer's and precent them from developing the disease ..." - Eric Topol, Scripps Translational Science Institute
Anaclet_Gompf_Research retweeted
Real world sleep patterns and disease risk from >95,000 @uk_biobank participants @PLOSMedicine
6-8 hours of sleep duration is good and "can effectively reduce the risk of multiple diseases" (but that implies cause and effect, not established )
More REM linked to lower risk of 83 diseases, including dementia, Parkinson's and heart failure
More Deep sleep associated with lower risk of 7 diseases, such as Type 2 diabetes and major depressive disorder
journals.plos.org/plosmedici…
Anaclet_Gompf_Research retweeted
Today in @Nature, we report a new approach to studying human brain development and modeling disease in vivo.
Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.
To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.
We call these #xenocortical mice (XCX).
Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!
Link to the article below 👇
Even after the payments stopped, sleep was on average 8 min longer than before the study. That's not huge, but it might indicate rewarding effects of longer sleep (directly or indirectly via better daytime academic performance).
theconversation.com/we-paid-…
Anaclet_Gompf_Research retweeted
.@JAMAInternalMed recently published a thoughtful piece on public access calling for NIH to assert its position regarding compliance with the NIH Public Access Policy.
NIH has the right to make the Author Accepted Manuscript, which has been supported by taxpayers, public in PubMed Central at time of publication; a right which is independent from any publisher agreement.
This is a free path to compliance for authors, helping us ensure rapid public access to NIH-supported research results.