Our newest paper is out today in Nature showing how sensitive children’s immune responses are to bias from past immunity.
news.weill.cornell.edu/news/…
nature.com/articles/s41586-0…
Congratulations and completely expected to @victora_lab for becoming an HHMI investigator
hhmi.org/news/hhmi-invests-o…
PatWilsonLab retweeted
Gut of newborns has unique bacteria that produce serotonin and promote the development of immune cells that may prevent allergic reactions to food and beneficial gut microbes, according to a preclinical study from @WCMpeds.
bit.ly/3PjJDhi
Great job Josh! This was a "hunch" project that turned out to be so interesting once Josh dug in.
In a nutshell: How do you balance the need for maximum antibody diversity and adaptability with the requirement for maintaining the ability of an antibody to express well?
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This is an amazing and intuitive approach as @stutangye has done so well for decades
PatWilsonLab retweeted
Most recent work from the lab just out @Nature. By combining ancient DNA work, population genomics, and in vitro infections we show that the Black Death shaped the evolution of immune genes. Kuddos to co-first authors @TaurVil and Jennifer Klunk. nature.com/articles/s41586-0…
PatWilsonLab retweeted
A curated set of human immunoglobulin germline genes/alleles for better annotation of sequences encoding antibodies and antibody repertoires. It has potential to solve annotation problems you have not been aware of! #antibody #AIRRseq #repertoire
biorxiv.org/content/10.1101/…
PatWilsonLab retweeted
Antibodies are the product of evolution on two timescales: over millions of years in vertebrate populations, and within weeks of infection or 💉 in populations of B cells. We ask how those timescales interact in our paper out in @PLOSPathogens 🧵 1/n t.ly/U84Un
PatWilsonLab retweeted
2/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics jobs.utoronto.ca/job/Toronto…
PatWilsonLab retweeted
1/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics! jobs.utoronto.ca/job/Toronto…
Many thanks to the thoughtful and comprehensive commentary from @ShivPillai4 on our paper led by @SirirukCh about broadly protective mAbs against SARS-CoV-2, both out today in the JCI:
Comment:jci.org/articles/view/168080
Paper:jci.org/articles/view/166844
What a cool paper. I wonder if there are any active mutator mechanisms involved, analogous to AID in B cells.
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10