blsk: plevkalab structural virology โฃ๏ธ, #cryoEM #cryoET #Lightsheet ๐ฌ at @CEITEC_Brno | Tweets by students.
Brno, Czech Republic
Joined October 2017
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Stay tuned for more insights into viral entry mechanisms! ๐งซ
If you liked this #tweetorial, please retweet the first tweet.
xitter.cf/PlevkaLab/status/18613โฆ
Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells
nature.com/articles/s42003-0โฆ
#CEITECScience
9/9
โจ๐ก๐๐ช ๐ฃ๐๐ฃ๐๐ฅ ๐๐๐๐ฅ๐งโจ
We are happy to announce that the paper by Aygul Ishemgulova @IshemgulovaA and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @CommsBio! ๐ฆ
Letโs break it down!
๐งต
1/9
๐ช๐ต๐ ๐ฑ๐ผ๐ฒ๐ ๐๐ต๐ถ๐ ๐บ๐ฎ๐๐๐ฒ๐ฟ?
This study brings us closer to the fundamental understanding of the infection process.
8/9
๐ ๐ฒ๐บ๐ฏ๐ฟ๐ฎ๐ป๐ฒ ๐๐ฎ๐ฟ๐ฝ๐ถ๐ป๐ด ๐ฎ๐ป๐ฑ ๐ฒ๐ป๐ฑ๐ผ๐๐ผ๐บ๐ฒ ๐ฟ๐๐ฝ๐๐๐ฟ๐ฒ
Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture.
7/9
On the contrary, inhibition of endosome acidification didnโt stop genome-containing particles from exiting the endosomes.
6/9
๐๐ฎ๐ป ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐บ๐ฒ๐ฐ๐ต๐ฎ๐ป๐ถ๐๐บ๐ ๐ฏ๐ฒ ๐ถ๐ป๐๐ผ๐น๐๐ฒ๐ฑ? ๐ฆ
Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication.
5/9
๐๐ฒ๐ ๐๐ถ๐ป๐ฑ๐ถ๐ป๐ด๐
This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm.
3/9
#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis ๐ท However, the infection process was never observed ๐ช๐ฏ ๐ท๐ช๐ท๐ฐ - until now.
2/9
โจ๐ก๐๐ช ๐ฃ๐๐ฃ๐๐ฅ ๐๐๐๐ฅ๐งโจ
We are happy to announce that the paper by Aygul Ishemgulova @IshemgulovaA and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @CommsBio! ๐ฆ
Letโs break it down!
๐งต
1/9
Great news from Portugal! #phageTherapy
๐ข Historic day for Portugal and phage therapy! ๐ต๐น A framework was approved, allowing magistral preparation of personalized phage products. ๐ Grateful to Jean-Paul Pirnay, my group @AzeredoLab Portuguese patients, and doctors who signed a petition inspired by the Belgium model.
Plevka Lab retweeted
#AlphaFold3 code & weights are now open-source for academics! ๐
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries!!
Repo: github.com/google-deepmind/aโฆ
๐จ๐ฟ Naลกe Dr. Lucie Valentovรก popsala svลฏj vรฝzkum bakteriofรกga JBD30 pro @CRozhlas ๐ข
V rozhovoru se dozvรญte, jakou novou, nรกmi popsanou, strategii pouลพรญvรก fรกg JDB30 na lov svรฉ koลisti - Pseudomonas aeruginosa ๐ฆ
Odkaz nรญลพe๐
If you are interested, find the tweetorial and the link to her paper below ๐
xitter.cf/PlevkaLab/status/18259โฆ
๐ข Publication alert ๐ข
Congratulations to Lucie Valentovรก on her debut paper! ๐
*Structure and replication of ๐๐ด๐ฆ๐ถ๐ฅ๐ฐ๐ฎ๐ฐ๐ฏ๐ข๐ด ๐ข๐ฆ๐ณ๐ถ๐จ๐ช๐ฏ๐ฐ๐ด๐ข phage JDB30* recently published in The EMBO Journal! embopress.org/doi/full/10.10โฆ
#PhageResearch
@CEITEC_Brno
๐งต1/12
๐ Congratulations to freshly minted doctor Lucie Valentovรก #PhDone ๐
We wish you all the best in your next chapterโyour passion and dedication will continue to inspire! ๐
#PhD #PhDlife #NextChapter
12/12
Thanks to our amazing collaborators for making this work possible - kudos especially to @Ceitec_CellimCF and @cemcof !
#CEITECScience #cryoEM #virus #AntibioticResistance
11/12
Weโve walked you through JBD30โs epic journey: from its flexible tail and high-tech docking system to taking over P. aeruginosa cells, assembling DNA-packed heads, and building the ultimate phage army. ๐โจ
10/12
Once inside, the phage takes control, turning the cell into a phage factory๐ญ
๐ ๏ธ Capsid proteins snap together into procapsids, which then expand - making room for the precious genome๐ฆ
๐งฉ With their heads full, they team up with the tails, creating the perfect phage squad!
