@PratLab

Prat Lab @CRCHUM. Unraveling the migration mechanisms of immune cells across the brain barriers in multiple sclerosis 🔬🧠 Tweets by lab members.

Joined August 2021
  • Tweets45
  • Following109
  • Followers276
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A la retraite du département de Neurosciences @chumontreal @CRCHUM @ChuSteJustine @UMontreal, de riches échanges se font entre chercheurs et cliniciens pour pousser la recherche sur les maladies du système nerveux encore plus loin
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Comprehensive and insightful review by @PratLab discussing the role of genes & environment on BBB disruption in MS and the therapeutic implications of mesenchymal stromal cells and antibodies targeting cell adhesion molecules or #fibrin to halt neurodegeneration. @TheLancetNeuro "Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies" thelancet.com/journals/laneu…
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In our January 2024 issue: the blood–brain barrier in multiple sclerosis, reviewed by Bettina Zierfuss and colleagues from @PratLab thelancet.com/journals/laneu…
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Please share! The 2024-2025 #endMS_SPRINT and 2024 #endMS_SummerSchool competitions are NOW OPEN! Inviting graduate students, post doctoral and clinical fellows, to apply by Feb 15, 2024. For complete details: endmstrainingprogram.ca @ChristinaWolfs1 @MSCanOfficial @umanitoba
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Excited to be part of @MSCanOfficial #EndMS 2023 in Toronto! I’m grateful for the chance to engage with the MS research community. I’ll be presenting the latest work on cytokines and endothelial barriers in the brain from the @PratLab with my poster #97 at 17:15, let’s connect!
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In this week’s #neuroimmunology special issue, Thai and @PratLab explore advances in immune cell carriers that ferry therapeutics across the #BloodBrainBarrier, which are opening a new frontier in #DrugDelivery for central nervous system disorders. @CRCHUM scim.ag/4PP
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Hoping to spread the word: We've started a study to see how circadian rhythms might affect those living with MS in Canada. Please share/RT across your networks! @KarimiLab @jrplemel @YegMs @TheNeuro_MNI @DCNSNeuro @PratLab @Craigurs @uOttawaBMRI @Raph_Schneider @UnityHealthTO
CircaPain@CircaPain16 Oct 2023
Do you live with Multiple Sclerosis? Do you experience pain and/or fatigue? Please consider participating in our sibling study CircaMS or sharing it with your network! Get involved and take the survey here: redcap.link/caoh8m30 Check out our website circams.ca/
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Very thrilled to have had the opportunity to present my PhD work in the @PratLab about the use of single-cell immune profiling for prediction of MS activity today at @ECTRIMS #MSMilan2023 🧠
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Leucocyte trafficking inhibition to modulate neuroinflammation: is MCAM a next generation target (and more clever than Natalizumab)? A commentary on novel findings and strategic thoughts around this: pubmed.ncbi.nlm.nih.gov/3694…

Targeting MCAM for next-generation modulation of leucocyte trafficking - PubMed

This scientific commentary refers to ‘MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes’ by Charabati et al. (https://doi.org/10.1093/ …

pubmed.ncbi.nlm.nih.gov
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If you’re interested in machine learning, come see my poster p290 ‘Machine Learning Identifies a Combination of Immunological and Clinical Parameters as the Best Predictor of MS Disease Progression’ at the #ACTRIMS2023 poster session tonight! #MultipleSclerosis @PratLab @endMS
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Which endothelial cell types are most responsive to neuroinflammation? Read our new article to find out and feel free to play with the two interactive R shiny applications to identify new targets for your projects. nn.neurology.org/content/10/…
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Our latest paper is out! The first "official" research paper of my beautiful CBN team @uhasselt, with @PhDory as first author (but this publication was a team effort!). Check it out! Especially if you're into #bloodbrainbarrier #multiplesclerosis 👇👇👇 link.springer.com/article/10…
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Check out the most recent publication from the Yong lab led by our talented Jeff Dong on how age impacts microglia's capacity to buffer CNS damage! nature.com/articles/s43587-0…
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Hideaki and I are soooo excited to share this study with all of you! We look forward to your feed-back. Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis academic.oup.com/brain/advan…

Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis

Nishihara et al. provide evidence for intrinsic dysfunction of the blood–brain barrier (BBB) in multiple sclerosis, by demonstrating impaired barrier prope

academic.oup.com
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An antibody therapy that selectively restrains the trafficking of pathogenic immune cells into the brain treats both relapsing-remitting and progressive neuroinflammation in mouse models, while avoiding side effects seen with previous approaches. @CRCHUM fcld.ly/n6ynwzp
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Our review on B cells in CNS disorders in now out! Take a look! nature.com/articles/s41577-0…
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Proud to have been involved in this amazing project🦠!! science.org/doi/10.1126/scia…

Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of...

Statistical models of plasma immunovirological features validate SARS-CoV-2 vRNA as an early predictor of COVID-19 mortality.

science.org
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CBN team in action today at #ISNI2021 with @PhDory, presenting her work on OSM signaling in neuroinflammation. Join us in Parallel Session IV "Barriers of the CNS" at 6.30PM CET! (Looking forward to talks of my postdoc lab @PratLab as well 😉) @BIOMED_UHasselt @GLW_UHasselt
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Marco Prinz, Anaelle Dumas & Katharina Borst review the immune & non-immune functions of #microglia authors.elsevier.com/a/1duzl…
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The @ISNI_neuro Global School of Neuroimmunology #GSNI is starting soon at 11:30 am CET, 5:50 am EST, 9:30 pm AEST. Profs Wee Yong, Martino, and Greer will open the first session on autoantibodies in #neuroimmunology by @RussellCDale. Join our community and tag us at #ISNI2021!
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