Professor of Biomedical Engineering at the University of Iowa. Leads the Multiscale Mechanics, Mechanobiology, and Tissue Engineering Lab.

Joined October 2015
New CMBE Issue Alert!!! 🧪🥼🦠 April 2025, Volume 18, Issue 2 Take a look to read about the newest advancements in cellular and molecular bioengineering research! link.springer.com/journal/12… Cover photo credit: J. Wang et al., 2025
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New CMBE Issue Alert!!! 🧪🥼🧫 February 2025, Volume 18, Issue 1 Check it out to read about new research in bioengineering like recent advances in optogenetics, 3D engineered human lymphatic vessels, and cervical/endometrial cancer screening methods! link.springer.com/journal/12…
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📢 BMES 2025 Abstract Submissions are OPEN! Showcase your research at the BMES Annual Meeting—the must-attend event for biomedical engineers! Don't miss this chance to present and connect with experts in the field. 🔗 Submit today: hubs.la/Q03cnk5Z0 📅 Deadline: May 1, 2025, at 11:59 PM ET #BMES2025 #BiomedicalEngineering #BME
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Liu et al. utilize a computational model approach to study the effect of ranolazine on failing hypertrophic cardiomyopathy cardiomyocytes. @sjtu1896 link.springer.com/article/10…
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Martinez-Zalbidea et al. created extracellular vesicles from CRISPR-dCas9 engineered mesenchymal stem cell line overexpressing TSG-6. The therapeutic effect of these vesicles was explored on in vitro human intervertebral disc cells. @RITtigers link.springer.com/article/10…
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Seymour et al. demonstrated the efficacy of using automated cell dispensing for high throughput screening of cervical and endometrial cancer in vitro models. @OregonStateBEE link.springer.com/article/10…
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Seibel et al. studied the effects of obesity-associated conditions (like chronic inflammation, hypoxia, and tissue hyperlipidemia) on lymphatic draining function using 3D engineered in vitro models of lymphatic vessels. @BostonU_BME link.springer.com/article/10…
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Taufalele et al. explore the effects of substrate stiffening on endothelial epigenetics, with a focus on DNA methylation. @VandyBME @creinhartking link.springer.com/article/10…
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Miyano et al. study the molecular mechanisms underlying hyperosmolarity-induced autophagy, specifically looking at the effects of transcription factor EB (TFEB) and Ca2+ signaling pathways. @TMU_PR @TUS_PR_en link.springer.com/article/10…
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📣📣 Exciting opportunity! The Freeman lab is #hiring a fully funded (@ERC_Research) PhD student to develop a lung metastasis-on-a-chip model for osteosarcoma. Come join my team @UCD_Mech_Eng and @UCD_Conway to advance cancer research with cutting-edge bioengineering techniques!
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My final editorial as departing Editor-in-Chief of @CMBEjournal is published and my friends, this one is a doozy. Hope you find it amusing and remember… Just Review It! #OpenAccess link.springer.com/article/10…
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Congrats @rileybehanbush !!
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Silva and Jacinto review recent engineering approaches to deliver wireless light to the brain for optogenetic applications. @UPorto link.springer.com/article/10…
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Xia et al. explore the damage mechanisms of endothelial networks under ultrasound cavitation. #HengyangUniversity #HuLab link.springer.com/article/10…
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Kerivan et al. demonstrate a new approach using QCM-D for deciphering the feedback mechanisms that drive emergent cytoskeletal ensemble crosstalk and intracellular mechanosensing. @OleMiss_MBELab @emkerivan @olemissengineer link.springer.com/article/10…
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Hirway et al. developed a multicellular computation model to investigate tumor microenvironment remodeling and pre-metastatic niche formation. @OhioStateBME @OSUengineering @SHWeinbergLab link.springer.com/article/10…
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📢We're recruiting! Please RT. Fully funded PhD studentship starting Oct 2025. Interested in #mechanobiology #CancerResearch #Immunology? Awesome project w/ @LeoneRossetti & @KoechlLab studying the impact of tissue mechanics on T-cells 👩‍🔬 kcl.ac.uk/dentistry/research…. Deadline 19 Jan
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Lowrey et al. present a coaxial 3D bioprinting technique to facilitate ultrasound-controlled gene delivery. #cmbeYI @AcoustiCarolyn @OHSU_BME link.springer.com/article/10…
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To improve mesenchymal stem cell (MSC) culture, Heinrichs et al. reduced the population of senescent cells with dasatinib, thereby improving MSC functionality. @DrRebekahSamson @UArkansas link.springer.com/article/10…
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Huang et al. present a comprehensive review of the current development and application of renal cancer organoids. #ChuanyuSunLab @FudanUni link.springer.com/article/10…
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