Into brains (+open science, procedural art, genomics, music...)
Paris, France
Joined December 2013
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Interested in the development of brain folding? We have 2 postdoc positions to study the molecular and mechanical causes of brain folding!
Thread 1: Modelling different hypotheses of brain folding
Thread 2: Multimodal, multi-scale atlas
@BorrellLab @neuroliege @Franze_Lab (1/3)
Roberto Toro [email protected] r3rt0.bsky.social retweeted
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @R3RT0 , doi.org/10.1101/2025.07.17.6…
Roberto Toro [email protected] r3rt0.bsky.social retweeted
19
Extra bonus: Flight through the whole brain connectomes of the 4 large brained species capuchin, colobus, macaque and mangabey.
Roberto Toro [email protected] r3rt0.bsky.social retweeted
12
All this suggests that mechanical morphogenesis may be a major 3rd causal determinant of the development and evolution of brain organisation in primates.
Roberto Toro [email protected] r3rt0.bsky.social retweeted
6
Zoom into illustration #2: New World monkeys like capuchins have much more folded brains than their Marmoset cousins. Surprisingly, their folding pattern is almost identical to that of Old World monkeys like macaques despite ~47my independent evolution—as much as whales&hippos!
Roberto Toro [email protected] r3rt0.bsky.social retweeted
5
Lining up primate brains solely based on their size provides a 1st striking illustration of the importance of mechanical morphogenesis: despite jumping across far branches of the phylogenetic tree, the sequence is continuous, hinting at a common underlying organising principle.
Roberto Toro [email protected] r3rt0.bsky.social retweeted
Lifestyle is a stronger predictor of aging and mortality than genetics.
A new Nature study of ~500,000 people found:
🎯 17% of mortality variation was linked to lifestyle (exposome).
🧬 <2% of was explained by genetics.
Here’s what you need to know 👇🧵 1/10
Roberto Toro [email protected] r3rt0.bsky.social retweeted
Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch
Read this #OpenAccess Research Article by Tim Yeung @tim_justina and David Wilkinson @TheCrick:
doi.org/10.1242/dev.204256
ALT Figure 1 (D) Transverse sections of hindbrain segment centre of r5 in WT embryo, representative of other hindbrain segments, at stages 20-42 hpf with HCR RNA-FISH for fgf20a (cyan), etv5b (magenta) and membrane markers EGFP-CAAX (white). Progenitors expressing etv5b are aligned with the position of fgf20a-expressing neurons, where the basal processes of these progenitors are adjacent to the signalling source. n≥8 per stage.
Roberto Toro [email protected] r3rt0.bsky.social retweeted
Svante Paäbo has been made Honoris Causa doctor of the University of Liège. Followed by a geeat meeting with him at GIGA on this occasion @GIGA_ULiege @UniversiteLiege @frsFNRS
Roberto Toro [email protected] r3rt0.bsky.social retweeted
ping @R3RT0
Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology | bioRxiv biorxiv.org/content/10.1101/…
Roberto Toro [email protected] r3rt0.bsky.social retweeted
🦠 For the next FRESK seminar on monday, December 9th, we meet Suchismita Das (LPENS) for the next presentation: "Active colloidal matter: flocking and wetting transitions"
qbio.ens.psl.eu/en/events/in…
Roberto Toro [email protected] r3rt0.bsky.social retweeted
Ce vendredi midi, la Caisse des Écoles de Paris Centre adopte le Croc de #notrecafemarais. 🙏à tous ceux qui ont participé à cette initiative et 👏à notre belle équipe Steeve, Nadine et Anastasia en cuisine à l’école de la place des Vosges.
#accessibiliteuniverselle
ALT Les professionnels de cuisine de l’école place des Vosges et l’équipe de notre café marais qui prépare le croc NCM
Thread 1: Modelling brain development (2/3)
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🚨 We’re hiring! 🚨 We're looking for a postdoc for our ERC Synergy project Unfold (unfold-lab.github.io). Join our lab at @institutpasteur to model brain morphogenesis! (1/10)
Thread 2: Multimodal atlas of brain development (3/3)
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🧠 Come work with us! Our lab at @institutpasteur
looks for a postdoc to help us create the most complete open atlas of brain folding development! This is part of our ERC Synergy project Unfold (unfold-lab.github.io). Join us! (1/10)
🧠 Come work with us! Our lab at @institutpasteur
looks for a postdoc to help us create the most complete open atlas of brain folding development! This is part of our ERC Synergy project Unfold (unfold-lab.github.io). Join us! (1/10)
📜 Profile: Neuroscientist with a quantitative background (eng/comp sci/maths), with experience working with pixels, voxels and meshes, computational neuroanatomy, programming skills (Python, Javascript) and passion for brain development 🔗 DM for info! Spread the word! (10/10)
Please repost 🙏 ! @BorrellLab @neuroliege @Franze_Lab @AmyFDHoward @SaadJbabdi @BrunoLevy01 @piloubazin @MichelTdS