The RESOLUTE & REsolution IMI consortia aim at triggering an escalation in the intensity of research on Solute Carriers (SLCs) transporters worldwide.
This work has received support from the …
Joined January 2019
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RESOLUTE - Research Empowerment on Solute Carriers retweeted
Paper(s) alert from our @RESOLUTE_IMI project – In a compilation of four papers in Molecular Systems Biology we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : biorxiv.org/content/10.1101/…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: doi.org/10.1101/2024.10.07.6…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Do you want to know with which proteins an SLC membrane transporter socializes? Our @RESOLUTE_IMI series of 4 manuscripts continues, and we are excited to share the so far most comprehensive interactome mapping of solute carriers biorxiv.org/content/10.1101/…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily (biorxiv.org/content/10.1101/…)!
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
Check out this tour-de-force in technology and assay development by our partners at Novartis, @mpi_mr_hd, and @CeMM_News: dlvr.it/T7Vyjf
Online now! AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells by Lars Hellweg, Kai Johnsson, @PLeippe, and colleagues at @EPFL_en @mpi_mr_hd @CeMM_News dlvr.it/T7Vyjf #chembiol
📢Dear followers! It has been an absolute pleasure to share news on Solute Carriers #SLCs transporters with you during the last 5 years! The RESOLUTE @IHIEurope project is ending soon, but all our resources and datasets are available at re-solute.eu/. #CarryTheTorch!
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Many SLC superfamily #transporters could be included on this schematic, including organellar Na+/H+ exchangers SLC9A9 and SLC9A6.
New online! Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes go.nature.com/3sNkqnh
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Structural basis of anticancer drug recognition and amino acid transport by LAT1 | bioRxiv
biorxiv.org/content/10.1101/…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Uncoupled substrate binding underlies the evolutionary switch between Na+ and H+-coupled prokaryotic aspartate transporters | bioRxiv
biorxiv.org/content/10.1101/…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
A massive @RESOLUTE_IMI collaboration with @CmdOxford, #nuvisan, @BiochemOxford, @CeMM_News, @Bayer, @UZH_en
Work of many many talented colleagues including @ProfSyK, @katharina_duerr, @DJ_Biophys, @BenediktKessler, @AlvaroIngles1, @giuliosf and numerous others
RESOLUTE - Research Empowerment on Solute Carriers retweeted
new release1
SpSLC9C1 in lipid nanodiscs
apo
8PCZ: dimer
8PD2,3,5,7: protomer state 1-4
w/ cAMP
8PD8: dimer
8PD9: protomer state 1
w/ cGMP
8PDU: dimer
8PDV: protomer
"Structures of a sperm-specific solute carrier gated by voltage and cAMP"
Paulino lab. Nature.
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP | Nature Comm
disq.us/t/4k7ovfm
#CryoEM #ABCtransporter #MembraneProteins
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Mimicking the regulatory state of a major facilitator superfamily sugar transporter | eLife
doi.org/10.7554/eLife.92462.…
#CryoEM #MFStransporter #MembraneProteins
RESOLUTE - Research Empowerment on Solute Carriers retweeted
New preprint from the lab and guess what, it is not about a membrane transporter😱: "Sensory kinase KdpD is a tandem serine histidine kinase controlling K+ pump KdpFABC on the translational and post-transcriptional level". A short thread... 1/4 biorxiv.org/content/10.1101/…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Cryo-EM structure of TMEM63C suggests it functions as a monomer | Nature Comm
disq.us/t/4k6wope
#CryoEM #MembraneProteins
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity | Cell Research
doi.org/10.1038/s41422-023-0…
#CryoEM #MembraneProteins
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics frontiersin.org/articles/10.…
RESOLUTE - Research Empowerment on Solute Carriers retweeted
Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP | eLife
doi.org/10.7554/eLife.87167.…
#CryoEM #antiporter #MembraneProteins
