RIOtrial (@RIOtrial) header
RIOtrial (@RIOtrial) profile picture

RIOtrial

@RIOtrial

The RIO trial is a study of a new type of #HIV treatment, broadly neutralising antibodies, in people diagnosed and treated in early HIV infection.

 United Kingdom
riotrial.org
Joined June 2021
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Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)Photo by RIOtrial (@RIOtrial)
To find out more about the #RIOtrial, check out short animated video link below. vimeo.com/453629820/31eb42a5… Credits: @HIViBase @AngelinaNamiba @ukcherub @sarahfidler4 @JohnFrater5 Will Everett, Hanna Box
Image from RIOtrial (@RIOtrial)
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Next up is Simon Collins @HIViBase who we're very privileged to have been part of the study from the very beginning as a community representative, sharing his insights on the importance of the study as well as community impact towards the study.
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Prof @JohnFrater5 @NDMOxford completing the laboratory journey of the participants' samples, and how we can analyse virology and immunology data in depth from these samples.
Image from RIOtrial (@RIOtrial)
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It's a celebratory #RIOtrial participant feedback meeting today! As Prof @sarahfidler4 explains, recruitment has completed and we are closer to being able to report the first findings of the study by early next year.
Image from RIOtrial (@RIOtrial)
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onlinelibrary.wiley.com/doi/… Check out this paper by RIO researcher @TTipoe from @JohnFrater5 lab @NDMOxford. He reports how HIV-specific T cell responses in people with HIV are impacted by ATIs.
Impact of antiretroviral therapy during primary HIV infection on T‐cell immunity after treatment...

Impact of antiretroviral therapy during primary HIV infection on T‐cell immunity after treatment...

Participants with primary HIV infection (PHI) on ART for 2 years (PITCH) exhibited immunodominant responses to Gag and/or Pol post-treatment interruption (TI) compared with pre-TI. In SPARTAC,...

onlinelibrary.wiley.com
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RIOtrial retweeted
Ming Lee (@jnim87) profile picture
Ming Lee@jnim8719 Aug 2024
onlinelibrary.wiley.com/doi/… Pleased to see our meta-analysis of the impact of ATIs and trial interventions eg. #bNAbs, on time to viral resuppression after restarting ART in cure-related studies. Shoutout to my student Miles Eason @ImperialMed, who drove this work & data collection
Image from Ming Lee (@jnim87)
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#AIDS2024 @PennyZach1 and @jnim87 present their poster comparing #BNAB sensitivity prediction outcomes using blood or gut proviral DNA and rebound plasma RNA in people treated during primary HIV infection.
Image from RIOtrial (@RIOtrial)
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More #HIVcure posters at #AIDS2024 #bNAb sensitivity testing in the @RIOtrial of long-acting 3BNC-117 and 10-1074 in PLWHIV started on ART in acute infection. Proviral DNA on ART and plasma RNA at time of viral rebound was tested using NIH or Rockerfeller models.
Image from Jillian Lau (@JillianLau1)
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Replying to @sarahfidler4
@sarahfidler4 from @imperialcollege starts her talk abt Key Partnerships for #HIVcure research w/ a primer on the contexts & challenges of cure trials, including interrupting treatment in a study. Sarah is such a clear and articulate speaker, always a joy to watch #AIDS2024
Image from Jillian Lau (@JillianLau1)
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▶️ Watch a free replay of our latest #webinar, "Analytical treatment interruptions in #HIV cure research", featuring IAS President @ProfSharonLewin, IAS Governing Council member @jnabukenya88, @Thumbi_Ndungu, @JillianLau1 & other leading voices! plus.iasociety.org/webcasts/…
Image from IAS - the International AIDS Society (@iasociety)
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For those attending #BHIVA24, please check out the poster on understanding participants perspectives around HIV cure-related research involving ATIs in UK, presented by Dr Godakandaarachchi @GSTTnhs
Image from RIOtrial (@RIOtrial)
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To find out more about the #RIOtrial, visit RIOtrial.org
RIO HIV Trial - Viral suppression off ART using dual bNAb therapy

RIO HIV Trial - Viral suppression off ART using dual bNAb therapy

RIO is looking at whether a new type of treatment, called bNAbs can keep viral load undetectable without antiretroviral treatment (ART)

riotrial.org
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frontiersin.org/journals/imm… @PennyZach1 @JohnFrater5 @NDMOxford report that 29% of a UK cohort of people treated in PHI had predicted resistance to 10-1074 by single genome Env sequence prediction algorithm. This highlights the need for bNAb resistance screening in clinical trials.
Image from RIOtrial (@RIOtrial)
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Dr Amanda Clarke and Caroline Cable from @BSUHresearch share their experiences working on the #RIOtrial. @UHSussex is one of our 12 clinical sites participating in the study! To watch and find out more, visit riotrial.org 🌟💫
Image from RIOtrial (@RIOtrial)
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vimeo.com/886495898/2bb039f3… Watch Prof Sarah Fidler speak to Ms Louise Terry, a research nurse working on the #RIOtrial, to find out what's it like working on the study.
Image from RIOtrial (@RIOtrial)
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People living with HIV were surveyed on their views on joining studies like #RIOtrial which involving temporarily stopping ART (also known as ATIs). Read the paper by members of the RIO and HEATHER studies here! 🔽
Ming Lee (@jnim87) profile pictureMing Lee@jnim8718 Dec 2023
Our paper on understanding participants' perspectives around cure-related studies involving analytical treatment interruptions is now out in JVE! Read it here🔽 sciencedirect.com/science/ar… #HIV #ATI #curestudies
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🎙️vimeo.com/877037653/739f23f5… 🎙️ Johan, who is currently participating in the #RIOtrial, kindly agreed to share his experiences and feelings with Prof. Sarah Fidler about pausing antiretroviral therapy (ART) as part of the trial. Watch the #ParticipantInterview now ⬆️
RIO Trial – Interview with a participant

RIO Trial – Interview with a participant

A RIO Trial participant kindly agreed to sit down with the RIO Trial Chief Investigator, Prof. Sarah Fidler. In the interview they give a firsthand account of their experiences taking part in the...

vimeo.com
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RIOtrial retweeted
Ming Lee (@jnim87) profile picture
Ming Lee@jnim8720 Oct 2023
Check out these eposters at #EACS2023 EP.A.061 attitude towards participation in cure trials which include a TI EP.A.110 The impact of TIs on viral resuppression EP.B2.042 Comparing CVS risk models in people living with HIV on modern ART.
Image from Ming Lee (@jnim87)
Image from Ming Lee (@jnim87)
Image from Ming Lee (@jnim87)
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Prof @SarahFidler7 gives an update on treatment interruption trials at #EACS2023
Image from RIOtrial (@RIOtrial)
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We're delighted to welcome the latest site offering the RIO study, based at the Churchill Hospital CCVTM in Oxford, bringing the total number of study sites to 12!
Image from RIOtrial (@RIOtrial)
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Missed #IAS2023? Dr @jnim87 and colleagues discuss #RIOtrial and other exciting updates from the cobference, available on the @STI_BMJ podcast now! 🔊 stibmj.podbean.com/e/ias23-c…
IAS23 Conference Feedback in Brisbane, Australia in July 2023 | STI...

IAS23 Conference Feedback in Brisbane, Australia in July 2023 | STI...

Welcome to the 4th episode of the 2023 BMJ Sexually Transmitted Infections Podcast Series. This year the International AIDS Society Conference was held for the first time in Brisbane Australia in...

stibmj.podbean.com
Ming Lee (@jnim87) profile pictureMing Lee@jnim8718 Sep 2023
I had the pleasure of discussing #IAS2023 updates with Dr @fabiolamartin00, Prof Damian Purcell & Dr Meg Doherty on the @STI_BMJ podcast. 🎧 bit.ly/46k80S90 Listen to the latest news including #HIV trials, cure-related news (including the RIOtrial), prevention and more!
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