Ryan KC Yuen (@RKCYuen) header
Ryan KC Yuen (@RKCYuen) profile picture

Ryan KC Yuen

@RKCYuen

Senior Scientist, Associate Professor (@SickKidsNews, @UofT) | Focuses on understanding the genetic architectures of complex disorders | Views are my own

 Toronto, Canada
lab.research.sickkids.ca/yuen/
Joined July 2020
  • Tweets89
  • Following141
  • Followers135
3Media
Photo by Ryan KC Yuen (@RKCYuen)Photo by Ryan KC Yuen (@RKCYuen)Photo by Ryan KC Yuen (@RKCYuen)
Ryan KC Yuen retweeted
Brain Canada (@BrainCanada) profile picture
Brain Canada@BrainCanadaApr 14
🧠 We're proud to announce the 10 recipients of this year's Momentum Grants, doubling our investment to $2M to fuel bold brain research across Canada. Thank you to our partners: @azrielifdn, @HeartandStroke, Hewitt Foundation. Learn more 👉 braincanada.ca/announcements… #BrainCanada #MomentumGrants #Neuroscience
Image from Brain Canada (@BrainCanada)
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Our new @molpsychiatry study suggests tandem repeat expansions may act as modifiers for tuning gene function and shaping risk in schizophrenia: nature.com/articles/s41380-0… @SickKidsNews @BrainCanada @CIHR_IRSC

Genome-wide tandem repeat expansions modify schizophrenia risk in the presence of a 22q11.2 deletion

Molecular Psychiatry - Genome-wide tandem repeat expansions modify schizophrenia risk in the presence of a 22q11.2 deletion

nature.com
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Short Tandem Repeats May Shape Disease Severity, Treatment Response Changes within #STRs influence phenotypic variation within diseases and help explain why some treatments work better for some patients @RKCYuen @SickKidsNews #geneticvariation hubs.li/Q03Tydng0
Short Tandem Repeats May Shape Disease Severity, Treatment Response

Short Tandem Repeats May Shape Disease Severity, Treatment Response

Changes within STRs influence phenotypic variation within diseases and help explain why some treatments work better for some patients.

insideprecisionmedicine.com
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🚨Our new findings @GenomeBiology: ~7% of short tandem repeats (#STRs) vary in motif sequence, not just length, across human populations. “Variable STRs” cluster near Alu elements & brain gene splice sites, pointing to roles in #disease risk. 🔗 Read more: doi.org/10.1186/s13059-025-0…

Diverse short tandem repeat sequences influence gene regulation in human populations

Genome Biology - Short tandem repeat (STR) length is a known determinant of pathogenicity in a variety of human disorders. The repeat sequence itself can modulate disease severity and penetrance;...

link.springer.com
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Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes @ljsznajder @unlvfootball nature.com/articles/s41593-0…
Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA...

Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA...

Nature Neuroscience - Sznajder et al. identified a molecular link between autism and myotonic dystrophy, showing that a tandem repeat mutation in a single gene can disrupt splicing of multiple...

nature.com
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Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes nature.com/articles/s41593-0…
Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA...

Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA...

Nature Neuroscience - Sznajder et al. identified a molecular link between autism and myotonic dystrophy, showing that a tandem repeat mutation in a single gene can disrupt splicing of multiple...

nature.com
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A genetic link between myotonic dystrophy type 1 (DM1) and #autism spectrum disorder may explain how autism develops in the general population. Read more about the #SKResearch in @NatureNeuro⤵️ sickkids.ca/en/news/archive/…
Study reveals new genetic mechanism behind autism development

Study reveals new genetic mechanism behind autism development

Researchers have identified a genetic link between myotonic dystrophy and autism spectrum disorder, which may explain how autism develops in the general population.

sickkids.ca
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Boost your brain this #BrainAwarenessWeek by learning more about impactful research happening in Canada. @azrielifdn Future Leader @RKCYuen (@SickKidsNews) discovered and patented a method to detect tandem repeat expansions in complex brain disorders. braincanada.ca/new-method-id…

Genomic dark matter behind brain disorders

braincanada.ca
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Scientists locate a genetic variation that may cause 4% of #cardiomyopathy cases, an inherited heart condition. 🫀 #SKResearch this #HeartMonth in @eBioMedicine from Drs. @RKCYuen and @seema_mital may lead to future #PrecisionChildHealth therapies. Read➡️bit.ly/3SYOHbM
Image from The Hospital for Sick Children (SickKids) (@SickKidsNews)
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Whole genome sequencing reveals new genetic marker for cardiomyopathy! Using computational methods developed at @SickKidsNews, @seema_mital @RKCYuen and team identify tandem repeats are expanded in DNA of patients with cardiomyopathy. Check it out: sickkids.ca/en/news/archive/…
Whole genome sequencing reveals new genetic marker for cardiomyopathy

Whole genome sequencing reveals new genetic marker for cardiomyopathy

Using computational methods developed at SickKids, scientists identify tandem repeats are expanded in DNA of patients with cardiomyopathy.

sickkids.ca
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New Publication Alert!🚨 Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy. Now in @TheLancet eBioMedicine. @seema_mital @RKCYuen and team laid the groundwork for early detection of and future precision therapies for CMP. thelancet.com/journals/ebiom…
Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

Our findings highlight the underrecognized contribution of rare tandem repeat expansions to the risk of cardiomyopathy and suggest that rare TREs contribute to ∼4% of cardiomyopathy risk.

thelancet.com
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It's my pleasure to work with the journal and the experts in the field to put together this issue of #DNA Repeat Expansion in #Disease. It captures the latest advances in the #tandem_repeat research. Please check it out!
Portland Press (@PPPublishing) profile picturePortland Press@PPPublishing12 Jan 2024
Unravel the complexities of DNA repeat expansions linked to various disorders! Explore summaries of the latest breakthroughs in this #ETLS themed issue, expertly curated by guest editor @RKCYuen. 🧬 ow.ly/PxPg50QmZ1s
Emerging Topics in Life Sciences, Volume 7, Issue 3, December 2023 front cover.

ALT Emerging Topics in Life Sciences, Volume 7, Issue 3, December 2023 front cover.

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Unravel the complexities of DNA repeat expansions linked to various disorders! Explore summaries of the latest breakthroughs in this #ETLS themed issue, expertly curated by guest editor @RKCYuen. 🧬 ow.ly/PxPg50QmZ1s
Emerging Topics in Life Sciences, Volume 7, Issue 3, December 2023 front cover.

ALT Emerging Topics in Life Sciences, Volume 7, Issue 3, December 2023 front cover.

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There's still time to register for our special seminar tomorrow (26th September 2 to 3pm BST), where we'll collaborate with special guests from @KargerPublisher 🙌 Don't miss this exciting opportunity 💫 Register now: ow.ly/a5Oe50PlGZ5 @PeerRevWeek @ResearchKarger
Green square with headshots of two speakers Professor Perdry and Dr Herzig from Karger publishers.

ALT Green square with headshots of two speakers Professor Perdry and Dr Herzig from Karger publishers.

Green square with headshots of two speakers Kristina Ibanez Garikano, Maryam Abdollahyan and Sasha Mitina from the Genomics England Research Community.

ALT Green square with headshots of two speakers Kristina Ibanez Garikano, Maryam Abdollahyan and Sasha Mitina from the Genomics England Research Community.

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Ryan KC Yuen retweeted
Mike Eberle (@MikeEberle) profile picture
Mike Eberle@MikeEberle15 May 2023
Our preprint describing the Tandem Repeat Genotyping Tool (TRGT) is now available. In this paper we describe how TRGT combined with long and accurate @PacBio sequencing can detect all of the features known to be associated with tandem repeats. biorxiv.org/content/10.1101/…
Resolving the unsolved: Comprehensive assessment of tandem repeats at scale

Resolving the unsolved: Comprehensive assessment of tandem repeats at scale

Tandem repeat (TR) variation is associated with gene expression changes and over 50 rare monogenic diseases. Recent advances in sequencing have enabled accurate, long reads that can characterize the...

biorxiv.org
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Using computational methods developed at SickKids, recent #SKResearch from @RKCYuen conducted #GenomeSequencing & linked rare tandem repeats, the repetition of a single DNA sequence, to specific genes associated with #schizophrenia. 🧬🧬🧬 Read more ➡️ bit.ly/3PtOB9T
Image from The Hospital for Sick Children (SickKids) (@SickKidsNews)
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Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia nature.com/articles/s41380-0…
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World’s largest autism whole #GenomeSequencing study reveals 134 autism-linked genes & range of genetic changes likely to be associated with #ASD – a massive step forward in better understanding the genomic architecture of #autism. Read the #SKResearch ➡️ bit.ly/3thlHzR
Image from The Hospital for Sick Children (SickKids) (@SickKidsNews)
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Interested in studying #genomics of neurodevelopmental disorders? We are looking for a #postdoc. Come join us!
jobRxiv (@jobRxiv) profile picturejobRxiv
@jobRxiv21 Sep 2022
Postdoctoral Research Fellow position in neurodevelopmental genetics research with @RKCYuen The Hospital for Sick Children, Toronto, Canada jobrxiv.org/job/the-hospital… #ScienceJobs #postdocjobs
Image from jobRxiv (@jobRxiv)
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I am very excited to share our manuscript, A genome-wide atlas of recurrent repeat expansions, available on @biorxiv biorxiv.org/content/10.1101/… This paper has everything, cancer genomics, chemical biology, HiFi sequencing …
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