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RNAi papers

@RNAi_papers

Twitter bot searching the web for new journal articles on #RNAi therapeutics for plants and animals

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Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer dlvr.it/T1C0T9
Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer - PubMed

Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer - PubMed

Background: Deficiencies in DNA damage repair responses promote chemotherapy sensitivity of tumor cells. The Nibrin homolog encoding gene Nijmegen Breakage Syndrome 1 (NBS1) is a crucial component of...

pubmed.ncbi.nlm.nih.gov
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OsMKK1 is a novel element that positively regulates the Xa21-mediated resistance response to Xanthomonas oryzae pv. oryzae in rice dlvr.it/T1BnYd
OsMKK1 is a novel element that positively regulates the Xa21-mediated resistance response to...

OsMKK1 is a novel element that positively regulates the Xa21-mediated resistance response to...

OsMKK1, a MAPK gene, positively regulates rice Xa21-mediated resistance response and also plays roles in normal growth and development process of rice. The mitogen-activated protein kinase (MAPK)...

pubmed.ncbi.nlm.nih.gov
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An In-silico Approach to Design and Validate siRNA against Monkeypox Virus dlvr.it/T0yWPB
An In-silico Approach to Design and Validate siRNA against Monkeypox Virus - PubMed

An In-silico Approach to Design and Validate siRNA against Monkeypox Virus - PubMed

Thus, the strategy may offer a platform for the development of potential antiviral RNA therapeutics that target MPXV at the genomic level.

pubmed.ncbi.nlm.nih.gov
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Lipophorin receptors genetically modulate neurodegeneration caused by reduction of Psn expression in the aging Drosophila brain dlvr.it/T0xQKQ
Lipophorin receptors genetically modulate neurodegeneration caused by reduction of Psn expression...

Lipophorin receptors genetically modulate neurodegeneration caused by reduction of Psn expression...

Mutations in the Presenilin (PSEN) genes are the most common cause of early-onset familial Alzheimer's disease (FAD). Studies in cell culture, in vitro biochemical systems, and knockin mice showed...

pubmed.ncbi.nlm.nih.gov
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RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding dlvr.it/T0vqkr
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Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation dlvr.it/T0klcn
Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early...

Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early...

Many compounds that were explored to modulate gene expression in liver fibrosis (models) were developed as anti-cancer agents. Their use in humans with impaired liver function is often impaired by...

pubmed.ncbi.nlm.nih.gov
21
Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human monocytes to ionizing radiation dlvr.it/T0hfvz
Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human...

Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human...

Circulating monocytes are important players of the inflammatory response to ionizing radiation (IR). These IR-resistant immune cells migrate to radiation-damaged tissues and differentiate into...

pubmed.ncbi.nlm.nih.gov
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Recent Advances in Engineering Carriers for siRNA Delivery dlvr.it/T0gCf3
Recent Advances in Engineering Carriers for siRNA Delivery - PubMed

Recent Advances in Engineering Carriers for siRNA Delivery - PubMed

RNA interference (RNAi) technology has been a promising treatment strategy for combating intractable diseases. However, the applications of RNAi in clinical are hampered by extracellular and intrac...

pubmed.ncbi.nlm.nih.gov
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STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis dlvr.it/T0TWfH
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis...

STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis...

The pathogenesis of Autoimmune Hepatitis (AIH) is closely associated with perturbations in iron ion metabolism, during which Stimulator of Interferon Genes (STING) plays an important role. However,...

pubmed.ncbi.nlm.nih.gov
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Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis dlvr.it/T0Rxv7
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MicroRNA-1 Deficiency Is a Primary Etiological Factor Disrupting Cardiac Contractility and Electrophysiological Homeostasis dlvr.it/T0RBDs
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Phenotypic profiling of solute carriers characterizes serine transport in cancer dlvr.it/T0RBCm
Phenotypic profiling of solute carriers characterizes serine transport in cancer - PubMed

Phenotypic profiling of solute carriers characterizes serine transport in cancer - PubMed

Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic requirements. Solute...

pubmed.ncbi.nlm.nih.gov
16
A nematode-inducible promoter can effectively drives RNAi construct to confer Meloidogyne incognita resistance in tomato dlvr.it/T0PXhw
A nematode-inducible promoter can effectively drives RNAi construct to confer Meloidogyne incognita...

A nematode-inducible promoter can effectively drives RNAi construct to confer Meloidogyne incognita...

Heterologous expression of a nematode-responsive promoter in tomato successfully driven the RNAi constructs to impart root-knot nematode resistance. The root-knot nematode Meloidogyne incognita...

pubmed.ncbi.nlm.nih.gov
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A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and Delivery Strategies for Cancer Therapy dlvr.it/T0HtHz
A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and...

A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and...

Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized exogenously to...

pubmed.ncbi.nlm.nih.gov
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Plasmid co-expressing siRNA-PD-1 and Endostatin carried by attenuated Salmonella enhanced the anti-melanoma effect via inhibiting the expression of PD-1 and VEGF on tumor-bearing mice dlvr.it/T0G7W6
Plasmid co-expressing siRNA-PD-1 and Endostatin carried by attenuated Salmonella enhanced the...

Plasmid co-expressing siRNA-PD-1 and Endostatin carried by attenuated Salmonella enhanced the...

Melanoma, the most perilous form of skin cancer, is known for its inherent resistance to chemotherapy. Even with advances in tumor immunotherapy, the survival of patients with advanced or recurrent...

pubmed.ncbi.nlm.nih.gov
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SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition dlvr.it/T0DSKf
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Co-Delivery of siNRF2 and Sorafenib by a "Click" Dual Functioned Hyperbranched Nanocarrier for Synergistically Inducing Ferroptosis in Hepatocellular Carcinoma dlvr.it/T0DSKS
Co-Delivery of siNRF2 and Sorafenib by a "Click" Dual Functioned Hyperbranched Nanocarrier for...

Co-Delivery of siNRF2 and Sorafenib by a "Click" Dual Functioned Hyperbranched Nanocarrier for...

In the course of antitumor therapy, the complex tumor microenvironment and drug-mediated changes in cell signaling and biological processes lead to drug resistance. The effect of sorafenib is greatly...

pubmed.ncbi.nlm.nih.gov
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Bleomycin promotes rAAV2 transduction via DNA-PKcs/Artemis-mediated DNA break repair pathways dlvr.it/T0DSJM
Bleomycin promotes rAAV2 transduction via DNA-PKcs/Artemis-mediated DNA break repair pathways -...

Bleomycin promotes rAAV2 transduction via DNA-PKcs/Artemis-mediated DNA break repair pathways -...

Because it is safe and has a simple genome, recombinant adeno-associated virus (rAAV) is an extremely appealing vector for delivery in in vivo gene therapy. However, its low transduction efficiency...

pubmed.ncbi.nlm.nih.gov
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Application of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells dlvr.it/T087qB
Application of mPEG-CS-cRGD/ Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by...

Application of mPEG-CS-cRGD/ Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by...

Although surgery-based comprehensive therapy is becoming the main approach to treat laryngeal cancer, recurrence, metastasis, radiotherapy resistance and chemotherapy tolerance are still the main...

pubmed.ncbi.nlm.nih.gov
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In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition dlvr.it/T04tTz
In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance...

In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance...

Hematopoietic stem/progenitor cell (HSPC)-based anti-HIV-1 gene therapy holds great promise to eradicate HIV-1 or to provide long-term remission through a continuous supply of anti-HIV-1 gene-modif...

pubmed.ncbi.nlm.nih.gov
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