Ralser Lab retweeted
How can drug candidates be optimized early in drug discovery so that they have as few unwanted effects as possible? Using modern protein analysis and #AI, #CharitéBerlin researchers are now showing how this can be done using a new class of compounds:charite.de/en/research/paper…
ALT Using an innovative combination of mass spectrometry and AI, Charité researchers were able to identify the prostate cancer drug candidates with the least unwanted effects among nearly 200 compound variants. © Charité | Arne Sattler
Ralser Lab retweeted
Wie lassen sich Wirkstoffe schon früh in der Arzneimittelentwicklung so optimieren, dass sie möglichst wenige unerwünschte Effekte zeigen? Mit moderner Protein-Analyse und #KI, zeigen #CharitéBerlin-Forschende jetzt am Beispiel einer neuen Wirkstoffklasse:charite.de/forschung/paper_s…
ALT Mithilfe einer innovativen Kombination von Massenspektrometrie und KI ließen sich unter knapp 200 Wirkstoffkandidaten gegen Prostatakrebs solche mit den geringsten unerwünschten Effekten identifizieren. © Charité | Arne Sattler
nature.com/articles/s41589-0… Proteome guided Drug development rocks! Read about how we used it to improve an Androgen Receptor targeting PROTAC, developed for the treatment of prorstate cancer
Urinary tract fungal infections are often difficult to treat, in part as a key drug, flucytosine, does not work well in these infections. We believe a human metabolite is to blame. biorxiv.org/content/10.64898…
On this day, 70 years ago, as an attaché of the Icelandic Olympic team, my great-uncle helped welcome the Olympic flame in Cortina. I have this commemorative diploma hanging on my wall 🙂 Now it’s there again 🙂 #MilanoCortina2026
Ralser Lab retweeted
🔬 Developed OSPP for consistent, cross-platform plasma proteomics, enhancing accuracy and reproducibility.
🔗 doi.org/10.1038/s41467-025-6…
#Proteomics #MassSpec #MatthiasMann
Ten years seems a lot of time in science :-) After our attempt to write a comprehensive reflection on the pentose phosphate pathway in 2015, we teamed up again to write about glycolysis. Metabolism rocks & I have plans for 2035 :-) onlinelibrary.wiley.com/doi/…
Registration is open for our St Nicholaus Symposium, a meanwhile traditional event to get our Berlin Mass Spectrometry community together @ChariteBerlin @MDC_Berlin , and @BerlinUAlliance
Ralser Lab retweeted
Obituary: John Gurdon (1933-2025) Biologist who made cloning possible
go.nature.com/4oyd8eC
We don't know the (phenotypic) consequences of most mutations. Good news, the proteome can help! And it predicts phenotypes in new environments. science.org/doi/10.1126/scie…
Difficult to predict Nobel Prizes... but if you would ask me for a gut feeling, I would look closely at Metabolism this year.
the sign is still there, but the the once proud, highest tree of Berlin is gone. Lost in the storm. #monuments of climate change.
Ralser Lab retweeted
Are you a theoretical biologist intererested in the ecology and evolution of metabolic interactions among microorganisms?
Do you like to work with experimentalists?
Do you have a PhD and experience in modelling + statistics?
Then this might be for you:
shorturl.at/iiiOv
Ralser Lab retweeted
Registration is now open for early-career researchers to apply for a funded place at our Workshop on Revisiting Metabolic Fundamentals, organised by @lydfinley& @WilhelmPalm. Find out more and apply at biologists.com/workshops/apr…
#BiologistsWorkshops
Vividly remember the journal club when we discussed this manuscript- 15 years ago- now retracted, 15 years later. Take home message: if you make big claims, try to have direct evidence - in this case AS analytics, which would have been availbe at the time nature.com/articles/d41586-0…
Why are antiungals often ineffective? We mined current clinical guidelines, and found that many drugs that are administered to patients with high risk of fungal infections, interfere with antifungals. doi.org/10.1099/jmm.0.002046
Ralser Lab retweeted
The Yeast2025 meeting in Paris is over, and was so much fun. It was exciting to see a room full of yeast biologists, with more than 500 people. It was also great to be part of the dream team of organizers, led by Gilles Fischer!
Ralser Lab retweeted
Registration is open (and free) for this year's Midwest Metabolism/Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) Annual Conference at the University of Michigan November 10–11, 2025. Hope to see you there!
vai.org/event/2025-midwest-m…
Loa Loa, an eye worm infection, is a neglected tropical disease. Diagnostics is only self-reporting, i.e. if some sees a worm in your eye. Proteomics can now help to indify biomarkers and to develop diagnostics academic.oup.com/jid/advance…
Proteome-driven regulation of fatty acid biosynthesis seems important for glucose-stimulated insulin secretion. analyticalsciencejournals.on…
