Reprogenetics Institute

Thanks to @JonathanAnomaly of @herasight for the talk! YouTube link: youtube.com/watch?v=TGniGUku…

Should polygenic embryo scores be kept from parents because probability is confusing? Dr. Jonathan Anomaly, co-founder of Herasight, spoke at Reproductive Frontiers 2026 about enabling informed choice that's better than government control. YouTube link in reply. ⬇️ Timestamps: 00:00:00 Intro 00:01:36 Informed choice vs. paternalism 00:02:59 Genetic testing laws in Europe 00:06:23 Reasons to restrict testing 00:08:07 Decision fatigue and the paradox of choice 00:14:31 Complex, probabilistic choices are everywhere 00:17:57 How companies can promote informed choice 00:19:54 Pleiotropy 00:29:10 Presenting results; closing thoughts 00:33:23 Q&A

Thanks to Dr. Eriona Hysolli for the talk! YouTube link: youtube.com/watch?v=BdYVCf3l…

Should we correct disease mutations before a child is born? Dr. Eriona Hysolli, formerly @ Church lab & Colossal Bio, spoke at Reproductive Frontiers 2026 about why embryo-stage prevention of severe genetic disease deserves a path forward. YouTube link in reply.⬇️ Timestamps: 00:00:00 Intro 00:01:07 Why embryo editing, and why now 00:03:18 The toolkit: from CRISPR-Cas9 to base editors 00:06:07 Multiplex editing, recoding, and the mammoth mouse 00:09:37 Human embryo editing with CRISPR-Cas9, 2015-2020 00:16:23 Base editors in human embryos 00:19:15 Why pursue prevention 00:23:11 Precedents: IVF and mitochondrial replacement 00:26:39 Regulation in the US and worldwide 00:30:11 Concluding remarks 00:31:56 Q&A

Thanks to @leo_jwu for the talk! YouTube link: youtube.com/watch?v=KwrKdzLa…

Can we grow a human blastocyst from stem cells, and watch it implant? Prof. Jun Wu of UT Southwestern spoke at Reproductive Frontiers 2026 about creating embryo-like structures that can implant into endometrial organoids. YouTube link in reply. ⬇️ Timestamps: 00:00:00 Intro 00:00:46 Why build embryo models from stem cells 00:06:28 Making human blastoids 00:09:58 Implantation on an endometrial organoid chip 00:13:10 Implantation failure: patient cells and a drug screen 00:15:49 Assembled blastoids: trophectoderm via YAP 00:21:24 Mouse-human chimeras implant on the wrong side 00:23:44 FGF signaling sets the implantation side 00:27:04 Q&A

Happy Oct4 @velychko_s !

Uh, what is this? I don't think this counts as public. It seems to say I couldn't criticize the methods.

What about the IQ one?

THEY MADE A POTATO TOMATO link.springer.com/article/10…