Senior Research Fellow in Bioinformatics & Molecular Epidemiology @TrinityMed1. Adj Asst Prof in Stats @SETUIreland. Interested in omics approaches to medicine
Dublin City, Ireland
Joined April 2019
- Tweets2K
- Following2.3K
- Followers570
- Likes3.5K
Dr Rob Leigh retweeted
The genomic and epigenomic evolution of colorectal cancer
nature.com/articles/s41575-0…
Dr Rob Leigh retweeted
BacMap 3.0: a comprehensive knowledgebase of annotated bacterial genomes academic.oup.com/nar/advance…
Dr Rob Leigh retweeted
AlphaFold: predicting the protein structure from amino acid sequence for >200 million proteins (awarded @NobelPrize)
Today
Alpha Genome Atlas: predicting the molecular impact of all 9 billion variants of the human genome
nature.com/articles/d41586-0…
Dr Rob Leigh retweeted
In the latest issue! Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine dlvr.it/TVLJtL
Dr Rob Leigh retweeted
MCB's Priya Moorjani & her lab have developed a novel genomic analysis method that identified DNA inherited from two previously unknown ancient human relatives, providing new insights into the complexity of human evolution.
news.berkeley.edu/2026/07/30…
Dr Rob Leigh retweeted
Subnuclear architecture is more than structural scaffolding—it actively regulates gene expression. This study shows that repositioning bivalent genes within the nucleus can trigger their activation, adding a compelling spatial dimension to epigenetic regulation.
Nature research paper: Subnuclear genome compartmentalization controls bivalent chromatin activity
go.nature.com/4fjT3XC
Dr Rob Leigh retweeted
A prehistoric East-Asian Yersinia pestis genome and a ~5.3 ka trans-Eurasian expansion of plague nature.com/articles/s41467-0…
Dr Rob Leigh retweeted
I'm 1000 days sober today. 😊
In those 1000 days I left Ireland, moved to the Netherlands, started studying International Social Work, and now I’m getting ready to become a father.
Sobriety didn’t just change my habits, it changed my whole life.
#SoberLife #TherapyWorks
Dr Rob Leigh retweeted
In a new Science study, researchers report that specific regions dense in cytosine and guanosine dinucleotides are epigenetically modified during inflammation to enable gene expression and that these changes persist during the animal’s lifetime.
The finding has implications for understanding how the genome determines the longevity of memory, which affects tissue fitness.
Learn more in a new #SciencePerspective: scim.ag/3PCKQU1
Grand day for the Parish. Sincere gratitude to @RoseAnnekenny1, @CathalMcCrory1, and the wider @tilda_tcd team for supporting me through this process.
Linezolid resistance, normally vertical and chromosomal is showing up horizontally via mobile elements. Predictable, still consequential
The emergence and biological characteristics of linezolid-resistant Clostridioides difficile isolates in the Asia-Pacific Region tandfonline.com/doi/full/10.…
Dr Rob Leigh retweeted
Python is removing the GIL.
The GIL (Global Interpreter Lock) prevents you from running multi-threaded code.
That makes ML code, in particular, really hard to write in pure Python.
Here's what it takes to remove the GIL:
Dr Rob Leigh retweeted
🔍Analysis of whooping cough isolates from over 82 years reveals the 'bystander effect' of the pertussis vaccine, affecting the evolution of a non-target species. Valérie Bouchez and Sylvain Brisse take us behind the scenes of their latest publication🔗 microb.io/3NAN1WY
ALT Time-scaled phylogeny of Bordetella parapertussis. Credit: Bouchez et al. (2025)
Dr Rob Leigh retweeted
Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌
We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.
AI learns the language of sleep🧵
Dr Rob Leigh retweeted
"In many gene expression studies, cells are extracted by tissue dissociation and fluorescence-activated cell sorting (FACS), but the effect of these protocols on cellular transcriptomes is not well characterized and is often ignored."
nature.com/articles/nmeth.44…
Dr Rob Leigh retweeted
How well do mRNA levels predict protein levels in human tissues ?
A simple question confounded by a paradox.
Our @PLOSCompBiol article: doi.org/10.1371/journal.pcbi…
