@RomanThaler

Assistant Professor of Orthopedics @MayoClinic Author of Vitamin C epigenetically controls osteogenesis in Nature Comm. Read here: https://xitter.cf/t.co/3FNOJWZPse

Joined July 2018
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Read my latest #research on #VitaminC "Vitamin C epigenetically controls osteogenesis and bone mineralization", published with @SpringerNature in @NatureComms. My article demonstrates that Vitamin C’s epigenetic functions are central to bone formation & homeostasis.
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I’m excited and humbled by the honor of receiving the ASciNA Young Scientist award! This means a lot!
Ascina Inc@ascina7 Oct 2023
AT/USA – Die Forschenden Marlies Meisel, Kevin Schwarzwald und Ines Sturmlechner wurden für hervorragende Publikationen mit den diesjährigen ASciNA Awards des BMBWF ausgezeichnet. Die feierliche Verleihung fand im Rahmen des ARIT in Los Angeles statt. ascina.at/bundesminister-pol…
Portraits of ASciNA Awardees in 2023. Marlies Meisel, Kevin Schwarzwald, Ines Sturmlechner

ALT Portraits of ASciNA Awardees in 2023. Marlies Meisel, Kevin Schwarzwald, Ines Sturmlechner

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Check out our recent article on Tertiary Lymphoid Structures (TLS) and autoimmunity published in @ScienceTM led by @YukiSat71808438 in @MayoClinic . I'm incredibly proud to have been a part of the team science.org/doi/10.1126/scit… #Immunology #CD4Tcells #TLS #WeyandLab #GoronzyLab
Yuki Sato@YukiSat718084386 Sep 2023
Excited to share our findings on TLS and autoimmunity with the world in @ScienceTM! Thank you for my great collaborators @Abhinav_Jain_19, @ShozoOhtsuki, @sore117san, @i_sturmlechner, @KobeHipDoc2, @MdWarrington at CMW lab@Mayo! #tertiarylymphoidstructure science.org/doi/full/10.1126…
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A new study proposes that low VitC levels may contribute to the higher prevalence of bone-degenerative diseases in females & suggests leveraging this vitamin against these conditions @RomanThaler ow.ly/5LLf50Pw5v9
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I'm very pleased that our latest #research on #VitaminC has been published in @The_JBMR. Our collaborative work between @MayoClinic and @LBG_research shows that the female skeleton is much more sensitive to Vitamin C deficiency than the male skeleton. Https://doi.org/10.1002/jbmr…
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I'm excited to share our new collaborative #research from @MayoClinic and @UCSF on MED1 and dental lineage specification published with @SpringerNature in @CommsBio where we demonstrate that loss of MED1 causes hair growth on teeth! rdcu.be/dhOMt
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📢 Excited to share our recent review on "#Tcell fate decisions during memory cell generation with #aging" in Seminar In Immunology 📚🎉 A special shoutout to @i_sturmlechner, @YUNMU464602463 @sore117san Goronzy Lab @MayoClinic Read the full review: lnkd.in/gaTyWhxj

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Mediator 1 ablation in mice causes ectopic hair growth on incisors, and RNA-seq and ChIP-seq analysis further show that Med1 mediates changes in enhancer dynamics. @RomanThaler nature.com/articles/s42003-0…
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The Goronzy lab and the Baker lab @dbakerlab teamed up to write a timely focus article on senescent cells, cancer and anti-tumor immunity. @LuisIPrieto1 @MayoClinic @ScienceTM
Luis I. Prieto@LuisIPrieto17 Jun 2023
The role of senescent cells in cancer is convoluted by many factors. I'm excited to share this piece just published in @ScienceTM ! @i_sturmlechner and I share our thoughts about how senescent tumor cells modulate antitumor immunity. science.org/doi/10.1126/scit…

Senescent cells as thermostats of antitumor immunity

Harnessing the immunogenic potential of senescent cells may be a viable but context-dependent opportunity to boost antitumor immunity.

science.org
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Can you guess what this picture is? It's an image of Vitamin C, taken with polarised light. Vitamin C led to both the 1937 medicine and chemistry prizes: to Albert von Szent-Györgyi, who first isolated it, and Norman Haworth for determining its molecular structure.
Vitamin C imaged with polarised light

ALT Vitamin C imaged with polarised light

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Just out in @CellReports: Check out our newest study in which we identified a mechanism that protects against loss of human naive CD4 T cells with aging! @MayoClinic
Cell Reports@CellReports9 Mar 2023
TRIB2 safeguards naive T cell homeostasis during aging dlvr.it/Skf8sd
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Roman Thaler retweeted
Cell Reports@CellReports9 Mar 2023
TRIB2 safeguards naive T cell homeostasis during aging dlvr.it/Skf8sd
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Thank you @AFARorg for selecting me for a Glenn Foundation post-doc fellowship! I’m excited to be part of the AFAR community!
AFAR@AFARorg10 Nov 2022
With her 2022 Glenn Foundation for Medical Research #PostDoc #fellowship award, @i_sturmlechner will #research determinants regulating #memory cell #longevity and function in #olderadults. Learn more her AFAR grant here: bit.ly/3SGJMLt @MayoClinic
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I'm very grateful to my wonderful team @MayoClinic and all the fantastic collaborators! @LBG_research #osteology nature.com/articles/s41467-0…

Vitamin C epigenetically controls osteogenesis and bone mineralization

Nature Communications - For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central...

nature.com
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I’m very excited to share our new paper @NatureComms on an unexpected finding that established senescent cells actively suppress p53 activity. Thanks to all coauthors, @MayoClinic and editor & reviewers who helped improve the study! nature.com/articles/s41467-0…

Senescent cells limit p53 activity via multiple mechanisms to remain viable

Nature Communications - To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that...

nature.com
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I’m elated to be able to share our new story on p21 in @ScienceMagazine! I feel very lucky to have been part of two wonderful institutions @MayoClinic @univgroningen with fantastic collaborators! science.org/doi/10.1126/scie…

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

The cell cycle factor p21 concurrently induces proliferative arrest and immunosurveillance of cells under stress, controlling their fate.

science.org
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