Research Associate Professor at the Laureate Institute for Brain Research focused on computational neuroscience, interoception, emotion, and decision-making
Joined July 2019
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Huge congrats to Claire Lavalley on this new paper. nature.com/articles/s41398-0… Results show that methamphetamine users show a specific deficit in model-based planning, in which they fail to simulate plans with large short-term losses (elevated aversive pruning). Brief thread below!
Congrats to Navid on his new paper in Molecular Psychiatry! Computational modeling showed learning rates and uncertainty sensitivity could distinguish affective disorders from substance use disorders, while forgetting rate was affected transdiagnostically nature.com/articles/s41380-0…
Ryan Smith (@rssmith.bsky.social) retweeted
A nice podcast 'debate' with a colleague who has slightly different views about consciousness than me. (I had to leave 15 minutes before the end -- they ran over the allotted time -- in case you wonder why I suddenly disappear from the conversation!
youtu.be/R7insQBa-qo
Ryan Smith (@rssmith.bsky.social) retweeted
Computational modeling revealed that individuals with methamphetamine use disorder show reduced information-seeking and slower belief updating when trying to maximize long-term reward.
@CarterMGoldman @toru1789taka @RyanSmith_LIBR
nature.com/articles/s44271-0…
Congratulations to @toru1789taka and @CarterMGoldman on their newly published paper!
This paper shows that individuals with methamphetamine use disorder show reduced directed exploration and slower dynamic learning rates in both high/low anxiety states
nature.com/articles/s44271-0…
Big thanks to co-authors as well! @NRDlab @SamuelTaylorCS @KhalsaLab @mpwpaulus (and others without Twitter)
Groups also differed on a cognitive reflectiveness test, and a mediation model suggested differences in reflectiveness partially accounted for greater pruning in the methamphetamine users. The effect of anxiety induction on craving was also positively associated by pruning levels
These and other results in the paper could help explain difficulties considering abstinence and vulnerability to relapse. Big thanks to
@docqhuys @mpwpaulus @KhalsaLab @MarishkaMehta @SamuelTaylorCS and other twitterless co-authors for their very helpful contributions!
"The Inter-Personal Affect Regulation Test (IPART): a Performance-Based Assessment of the Ability to Improve the Emotions of Others"
emotionandpsychopathology.or…
Congratulations to co-first author Claire Lavalley on validating this new performance-based measure!
Very excited to congratulate Ning Li and Claire Lavalley on their new paper published in @molpsychiatry.
"Directed exploration is reduced by an aversive interoceptive state induction in healthy individuals but not in those with affective disorders" (nature.com/articles/s41380-0…) 🧵👇
In this model/task, the slower learning rates suggest that uncertainty in anxious depression may have reduced at a slower rate. Big thanks to our co-authors: @NRDlab @KhalsaLab @mpwpaulus @AnnieChuning @SamuelTaylorCS @CarterMGoldman @rowan_hodson @LIBR_Tulsa
Reinforcement Learning and Active Inference are two frameworks used in computational psychiatry, but these are rarely directly compared empirically. Here, we aimed to compare these in a more systematic manner by fitting each to multiple datasets: papers.ssrn.com/sol3/papers.…
We first compare their relative ability to account for behavior on a three-armed bandit task in a sample from the US and a sample from Taiwan. We then look at how the parameters correlate with each other and how strongly their mechanistic explanations overlap.