Mihaela Pruteanu, SPP1879 Managing Coordinator
Berlin, Germany
Joined April 2018
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It was a tremendous pleasure working with all SPP1879 members for the past 6 years and grateful to all amazing speakers that accepted our invitations to attend our SPP1879 international symposia!
A nice review of the DFG-SPP1879 International Symposium on Nucleotide Second Messenger Signaling in Bacteria (Berlin, 22nd to 25th May 2022) organized by Regine Hengge and Mihaela Pruteanu (Humboldt-Universität zu Berlin).
academic.oup.com/microlife/a…
Nucleotide Second Messengers in Bacteria retweeted
Great study about the link between c-di-AMP metabolism and cell wall integrity: @SPP1879
#Streptococcus agalactiae remains surprisingly sensitive to ß-lactams despite decades of use! 🧬🔬 @TerryBrissac et al. uncovers how c-di-AMP controls osmotic pressure and cell wall integrity, revealing clues to emerging resistance. #Antibiotics #AMR
academic.oup.com/microlife/a…
Nucleotide Second Messengers in Bacteria retweeted
WOW 👉Animal and bacterial viruses share conserved mechanisms of immune evasion:
👇👇👇
Cell cell.com/cell/fulltext/S0092…
Nucleotide Second Messengers in Bacteria retweeted
👉 From dusty shelves toward the spotlight: growing evidence for Ap4A as an alarmone in maintaining RNA stability and proteasis!
pubmed.ncbi.nlm.nih.gov/3921…
@SPP1879 #Ap4A #subtiwiki
Nucleotide Second Messengers in Bacteria retweeted
Posttranscriptional modification of #cdiAMP synthase DisA tunes down it's activity
a good read for @SPP1879 community
journals.asm.org/doi/10.1128…
Nucleotide Second Messengers in Bacteria retweeted
Cyclic di-AMP is an important signaling nucleotide in many prokaryotic lineages. This #MMBR review argues that the molecule is a master regulator of cell volume & that other cellular processes can be connected with cyclic di-AMP through this core function. asm.social/1Wn
ALT Cell volume regulation in response to osmotic fluctuations. (A) Schematic representation of the bacterial response to osmotic stress. (B) Overview of the bacterial osmolyte influx and efflux systems. Gray circles = cell wall; blue circles = cell membrane; red squares = cyclic di-AMP; open circles = osmolytes; gray arrows = turgor pressure; dashed arrows = movement of water; yellow star = phosphorylated site. Protein domains: green = RCK_C; light blue = CBS; Purple = USP.
Nucleotide Second Messengers in Bacteria retweeted
Wow: C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes:
biorxiv.org/content/10.1101/…
#cdAMP @SPP1879
Nucleotide Second Messengers in Bacteria retweeted
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Nucleotide Second Messengers in Bacteria retweeted
Apparently our latest paper just came out 🤩! Structures of the P. aeruginosa FleQ-FleN master regulators reveal large-scale conformational switching in motility and biofilm control. @PNASNews @ERC_Research @iecb_bordeaux @univbordeaux_EN @CNRSbiologie.
pnas.org/doi/abs/10.1073/pna…
Nucleotide Second Messengers in Bacteria retweeted
Happy to share our latest work on #cdiAMP signaling & natural #competence via #ComFB protein, a novel #cdiAMP receptor (widespread in bacteria 🦠)
Great collaboration w/ @Archaellum & @S_Shamphavi
Supported @spp2389 @SPP1879 @sfb1381 @BUnifr @CoE_CMFI
biorxiv.org/content/10.1101/…
Nucleotide Second Messengers in Bacteria retweeted
Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor | Science Advances science.org/doi/10.1126/scia…
Tour de force by @jiawei_xing assisted by @VadimMGumerov and performed at @MicrobiologyOSU
If you have a PAS domain, please, do send it to us 😎!
Nucleotide Second Messengers in Bacteria retweeted
The @VAAM_Microbes conference has started: Regine Hengge delivers the Schlegel lecture!
@SPP1879
Nucleotide Second Messengers in Bacteria retweeted
Excellent team effort spearheaded by twitterless Simon Brückner together with @BangeBalcony and @BegerowLab, and funded by @SPP1879 and @grk2341
pubmed.ncbi.nlm.nih.gov/3742…
Nucleotide Second Messengers in Bacteria retweeted
Finally the last lab day of my PhD has come... Saying goodbye to another beautiful E. coli macrocolony #biofilm 😍
Now on my way to @EMBLHeidelberg, looking forward to lots of science at #EESmicrobiology!
Nucleotide Second Messengers in Bacteria retweeted
Diving into biofilms 🤿 reveals beautiful cellular organization that affects substrate distribution and antibiotic tolerance. Exciting work by @HannahDayton , our collaborators @TheMinLab @ajlabny @jasnir_ Raju Tomer & their labs! #microanatomy
biorxiv.org/content/10.1101/…
Nucleotide Second Messengers in Bacteria retweeted
Now published in an updated form @NatureComms: rdcu.be/de23n
Thanks Michael Fuss, Jan-Philip Wiefering, @RobinCorey1, @YvonneHellmich1, @IgorTascon & Joana Sousa at @JanetVonck, @pstansfeld & @IHanelt labs for your fantastic work! @goetheuni @MPIbp @warwickuni @SPP1879
'Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation.' A fun collaboration with @JanetVonck and @pstansfeld labs headed by Michael Fuss, Jan-Philip Wieferig and @RobinCorey1. @SPP1879 @goetheuni @MPIbp biorxiv.org/content/10.1101/…
Nucleotide Second Messengers in Bacteria retweeted
µLife @microLifeJrnl now on PubMed!
Take a look into the versatile roles of the nucleotide second messengers #cdGMP #cdiAMP #ppGpp #AP4A #cAMP #cGMP in bacteria in our SPP1879 collection of papers in @microLifeJrnl
Great contributions from all SPP1879 members, PhD students and PIs!
academic.oup.com/microlife/i…
Nucleotide Second Messengers in Bacteria retweeted
Do you wonder what nucleotide-based second messengers do in archaea? We do!
Read about what is known here: doi.org/10.1093/femsml/uqad0…
@SPP1879 @BUnifr
Nucleotide Second Messengers in Bacteria retweeted
Should I stay or should I go 🦠 lovely new study on bimodal regulation of Pseudomonas aeruginosa biofilm heterogeneity by @Jenal_Lab @biozentrum @UniBasel_en
Readcube: rdcu.be/dd8Dg
nature.com/articles/s41564-0…
Nucleotide Second Messengers in Bacteria retweeted
Check out our newest publication from work funded by @dfg_public @SPP1879 . Spearheaded by twitterless #AnnaScherhag with excellent supervision by @SusanneZehner
µLife @microLifeJrnl now on PubMed!
Take a look into the versatile roles of the nucleotide second messengers #cdGMP #cdiAMP #ppGpp #AP4A #cAMP #cGMP in bacteria in our SPP1879 collection of papers in @microLifeJrnl
Great contributions from all SPP1879 members, PhD students and PIs!
academic.oup.com/microlife/i…