Sahar Hani retweeted
(1/2) When Janelia set out to map every neuron in the fly brain in 2008, many thought it couldn’t be done. Nearly 20 years later, a complete wiring diagram of the 166,000+ neurons of the adult male fruit fly is helping to reveal the brain’s secrets: bit.ly/4zT7jPf.
Sahar Hani retweeted
📽️ G&D Tapes 📽️
G&D Author, Marion Solbach Mouginot tells us about their recent study in #genesdev describing how meta-domains control neuronal gene expression.
Learn more here:
➡️ bit.ly/45wGi5M
#TAD #chromatin #transcription #neuron #drosophila #3Dgenome
Sahar Hani retweeted
We demonstrated the functional importance of RNA structure in plant domestication😊 How cucumbers got longer – and why it’s a big deal for farming | John Innes Centre @JohnInnesCentre jic.ac.uk/news/how-cucumbers…
Happy to share our recent work on extremely long-range (up to 5.1 Mb 😯) #regulation of certain #genes in fly neurons and provides new insights into how they form (short thread below 👇).
genesdev.cshlp.org/gca?gca=g…
Lola-I was, however, only required to form 1 meta-domain. This highlights a dichotomy between factors like Lola-I, which may control neuronal fate largely independently of inter-TAD interactions, & structural proteins like Cp190, which may enable ultra-long range gene regulation
This work was led by Marion Mouginot, who identified Lola-I as a meta-loop-associated factor, majorly supported by Maria Cristina Gambetta’s guidance, as well as @ariannaravera_ our image analysis expert at @unil 👏
Together, we also uncovered hierarchical meta-loop formation
Sahar Hani retweeted
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
biorxiv.org/content/10.1101/…
Sahar Hani retweeted
Our study is online @MolecularCell! Compared to our preprint (see previous 🧵), we added additional evidence that transcription factor exchange is required to prolong transcriptional burst duration. Thanks reviewers for suggesting this experiment. 1/4 dlvr.it/T2yqrm
Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.1101/…
Great collaboration with the Yi Lab for visualization of intracellular Pi distribution in plants! 🌱
Sahar Hani retweeted
Part of my PhD work @LRSV_Toulouse is published today @IJMS_MDPI. In this paper, we associate CIII Prxs to novel & specific roles in abiotic stress tolerance using natural variation. Thanks to @christopheDuna1 @EstevezJoseM @CyrilLibourel & Bruno Savelli.
mdpi.com/1422-0067/23/7/3960
Sahar Hani retweeted
Development of a split fluorescent protein-based RNA live-cell imaging system to visualize mRNA distribution in plants dlvr.it/SJZgMb
