Neurocritical care attending at BWH in Boston. Practical applications of advanced neuroimaging. Opinions here are mine.
Boston, MA
Joined June 2011
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Sam Snider retweeted
We all thought this study would fail, for different reasons.
Joe Taylor (1st author) thought it'd be a takedown of fMRI-guided TMS.
@foxmdphd and I (co-senior authors) thought the effect would be too small to detect in just 40 patients.
We were wrong.
jamanetwork.com/journals/jam…
Sam Snider retweeted
Two new tools to map the human brainstem:
nuclei: onlinelibrary.wiley.com/doi/…
bundles: pnas.org/doi/10.1073/pnas.25…
code: surfer.nmr.mgh.harvard.edu/f…
github.com/markolchanyi/BSBT
@olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_CNTR @MGBResearchNews @MIT
See our response to concerns raised about the validity of lesion network mapping here. IMO, initial critique published in @NatureNeuro does not hold up to scrutiny.
A recent paper in @NatureNeuro raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" biorxiv.org/content/10.64898…
Sam Snider retweeted
A recent paper in @NatureNeuro raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" biorxiv.org/content/10.64898…
Sam Snider retweeted
A new study shows that signature patterns of brain activity may help predict recovery from #TBI.
Read more from @SamBSnider and colleagues in @PNASNews: massgeneralbrigham.org/en/ab…
Sam Snider retweeted
~10 years ago we published a paper on anticorrelated brain networks, but are they useful clinically? New work from @SamBSnider @Brain_Circuits @ComaRecoveryLab in @PNASNews suggests they predict recovery from severe brain injury. Thread below:
We report a new biomarker for recovery from moderate/severe TBI:
The synchronized toggling of activity between "task-positive" and "task-negative" brain networks.
Out today in @PNASNews
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We report a new biomarker for recovery from moderate/severe TBI:
The synchronized toggling of activity between "task-positive" and "task-negative" brain networks.
Out today in @PNASNews
1/2
paper here: shorturl.at/Ow7wu
Collaboration between @BWHNeurology, @MGHNeurology, @imperialcollege, and the EU.
@foxmdphd @Brain_Circuits @ComaRecoveryLab @BWHNeurosurgery @Neurosharp @nsngraham
2/2
Sam Snider retweeted
Last week I lost a friend.
But the rest of the world lost a warrior.
A visionary who dedicated his life to healing the sick and relentlessly bulldozing any barriers that got in his way.
1/n
@NolanRyWilliams
Sam Snider retweeted
New research from @harvardmed
@brighamWomens
@brain_circuits:
We evaluated how DBS in Parkinson’s with Alzheimer’s influences cognition. Originally, it looked like DBS was deleterious for cognition in Parkinson’s, but could be beneficial in Alzheimer’s.
The BIS monitor is used in ORs around the world.
In patients comatose after cardiac arrest, we virtually-emulated BIS monitor output from clinical EEG.
A neural network trained on this data out performed clinical gold-standard at predicting recovery.
ow.ly/Q3ju50VvUnW
Sam Snider retweeted
In a new cover study, Snider et al. tested if internal EEG subparameters extracted by the BIS monitor—a device commonly used to estimate depth of #anesthesia intraoperatively—could be repurposed to predict recovery of consciousness after cardiac arrest: ow.ly/Q3ju50VvUnW
Sam Snider retweeted
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @NatureComms we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41467-0…
A 🧵 below:
Sam Snider retweeted
Visualizing Effective Connectivity in the Human Brain
Preprint: biorxiv.org/content/10.1101/…
Code: github.com/ComaRecoveryLab/S…
YouTube video: youtu.be/V0hqs-noYNg
Download video & figures: zenodo.org/records/14974861
Led by #XanderAtalay & #TeoFecchio
@MGH_CNTR @MGHMartinos @MGHNeuroICU
Sam Snider retweeted
Spaulding awarded two #TBI researchers $400K each in support of their new studies to understand mechanisms underlying disorders of consciousness & identify effective treatments. Learn about the Innovative Treatments in Disorders of Consciousness program: spklr.io/6017NvnZ.
ALT Joseph Giacino, PhD, smiles wearing a white lab coat.
ALT Craig Rovito, MD, smiles wearing a white lab coat.
Sam Snider retweeted
Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!
If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out!
gibsonlab.org
Sam Snider retweeted
"SQUEEZE MY HAND!"
Verbal commands like this are issued daily to traumatic brain injury patients in ICUs around the world.
Persistent absence of command following is felt to be a poor prognostic sign. Is it?
We share new results in @JAMANetworkOpen
1/4
Sam Snider retweeted
Despite the urge to prognosticate in the early days after severe TBI, these results suggest we might take a little pause and consider this new 1% rule.
After a severe TBI, the risk of unfavorable 1-yr outcome increases by 1% with each additional day without command-following .
This was observed in two independent studies, together including > 9,000 patients.
We dub this the "1% rule".
manuscript: tinyurl.com/yvs9s7xu
2/4
Sam Snider retweeted
Very cool work/pragmatic work @SamBSnider. Would be fascinating to see a similar study in patients that are comatose after #cardiacarrest. My guess is that it might become the 2% rule in that population...
"SQUEEZE MY HAND!"
Verbal commands like this are issued daily to traumatic brain injury patients in ICUs around the world.
Persistent absence of command following is felt to be a poor prognostic sign. Is it?
We share new results in @JAMANetworkOpen
1/4