This paper claims psychedelics induce neuroplasticity via direct activation of the BDNF receptor TrkB nature.com/articles/s41593-0… Before you reach a conclusion, see our paper @scisignal; 40K+ compounds were tested, none activates TrkB! science.org/doi/10.1126/scis… #psychedelics

Ariadne: a mythical princess or a forgotten molecule that can lead us to a new class of psychiatric medicines? We show that Ariadne is a psychoactive, but non-hallucinogenic 5-HT2AR agonist, with relatively low receptor signaling efficacy.pubs.acs.org/doi/10.1021/acs… #Pharmaceutical