Former PhD candidate in Mo Li lab | Currently Postdoctoral Fellow at Salk Institute | Ibn Rushd Fellow | Aging Research 🔬| Rusty Gage Lab
California, USA
Joined June 2017
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Excited to share our new preprint! We developed a novel neuronal model that preserves human neuronal aging signatures while recapitulating key neuropathological features of Alzheimer’s disease pubmed.ncbi.nlm.nih.gov/4285…
#Aging #Alzheimers #Neuroscience #Preprint
Samhan Alsolami retweeted
Sam's paper could transform the field. Making neurons from adult fibroblasts and packing them into 3D structures while preserving epigenetic signatures can transform the study of #AlzheimerDisease and other neurodegenerative disorders. @salkinstitute. pmc.ncbi.nlm.nih.gov/article…
Samhan Alsolami retweeted
Enjoyed reviewing and summarizing this important & reproducible (yes we tried it) paper on how DMSO is sufficient to induce human balstoids from human naive PSCs, emphasizing (again) the great importance cell state has on embryo models formed. Congrat to Mo Li group & @KAUST nature.com/articles/s41422-0…
Samhan Alsolami retweeted
The cancer-Alzheimer's paradox, an inverse correlation, with an unexplained mechanism
"The risk of Alzheimer’s disease in patients with cancer is significantly reduced, and the risk of cancer in patients with Alzheimer’s disease is halved."
nature.com/articles/s41514-0…
Samhan Alsolami retweeted
New episode of The ReProgram Podcast featuring Dr. Rich Miller! What does it actually mean to slow aging? youtube.com/watch?v=N_yzQUkf…
Samhan Alsolami retweeted
Thrilled that our paper is the cover story & featured paper in July issue of @cell_res!
We reveal a simple DMSO-based approach to human blastoid formation and uncover roles for lysosomal acidification and cellular biophysics
@KAUST_News @KAUST_BESE
rdcu.be/fp54G
Samhan Alsolami retweeted
Just as species diversify to occupy various ecological niches, neurons diversify to occupy computational niches. Primate neocortical expansion from V1 to lateral PFC led to adaptive radiation at the cellular level. Primate evolution did not spare levels. nature.com/articles/s41467-0…
Samhan Alsolami retweeted
Stable bioreactor control reveals acidic pH–driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells: Communications Biology, Published online: 15 April 2026; doi:10.1038/s42003-026-10013-5Acidic pH rewires human… dlvr.it/TSgFYw
Samhan Alsolami retweeted
Online Now! ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation dlvr.it/TT47LR #stemcells
Samhan Alsolami retweeted
China launches 'human artificial embryos' to space in bid to see whether reproduction is possible off-world
China's Tianzhou-10 mission just delivered embryo-like structures made from living stem cells to the Tiangong space station. Experiments could shed light on how radiation and microgravity affect human reproduction.
livescience.com/space/space-…
Samhan Alsolami retweeted
Great to see our latest paper featured in @arabnews @KaustResearch @Samhan182 @YingziZhang212 study explores how cells respond to acidic stress | Arab News arabnews.com/node/2643256/sa…
Samhan Alsolami retweeted
باحثون من جامعة كاوست طوروا نموذجًا مبسطًا يحاكي المراحل الأولى لتكوّن الجنين البشري ما قد يفتح آفاقًا جديدة لفهم أسباب فشل بعض عمليات أطفال الأنابيب، والإجهاض المبكر،
و أيضاً اكتشفوا دورًا محوريًا لمضخة V-ATPase في تكوين التجويف الجنيني المبكر، وهي خطوة أساسية لنجاح الحمل
Samhan Alsolami retweeted
يكشف باحثو كاوست كيفية تعزيز صحة خلايا الإنسان واستعادة قدرتها على إنتاج الطاقة حتى في ظروف الإجهاد الحمضي.
وتقدم الدراسة فرصاً مهمة لفهم أمراض مثل السرطان والالتهابات، وتطوير استراتيجيات جديدة لدعم صحة الإنسان، بما يعكس الدور المتنامي للمملكة في تعزيز البحث والابتكار على المستوى العالمي.
اعرف أكثر: ar.kaust.news/vUNP
Samhan Alsolami retweeted
New KAUST research shows that restoring a key energy molecule can partially reverse the effects of acidic stress in human cells, conditions found in cancer, inflammation, and aging.
The findings point toward new strategies to protect cells and support human health.
Explore the study: kaust.news/vUMQ
Samhan Alsolami retweeted
溶媒に汎用されるDMSOがBlastoid形成を誘導する驚きの報告。3%DMSOでヒトナイーブ幹細胞から内腔をもつBlastoid形成率が最大87％まで向上。DMSO→膜物性変化/TE分化を促進→V-ATPase上昇→内腔形成効率向上というモデル。DMSOがTE分化促進する直接機構は未解明。CellRes誌
nature.com/articles/s41422-0…
Samhan Alsolami retweeted
Excited to share our recent $13 Million CIRM Award to Fund Research on the Role of RNA Pollution in Neurodegenerative Diseases. @iachaim, Jerome Mertens, Rusty gage, Doug Galasko and Anne Bang today.ucsd.edu/story/13-mill…
Samhan Alsolami retweeted
Proud to share our work in Communications Biology! We show acidity reprograms cellular metabolism, causing mitochondrial dysfunction and an energy crisis🔗nature.com/articles/s42003-0…
Thanks to @Mo_Li_KAUST @Samhan182, the amazing team, and KAUST @KAUST_BESE @KaustResearch @KAUST_News
Samhan Alsolami retweeted
While the brain only takes up 2% of the volume of the human body, it uses 20% of your body's energy.
In this special video episode of our Beyond Lab Walls podcast, Salk President Gerald Joyce interviews neuroscientist Rusty Gage, who focuses on the plasticity, adaptability, and diversity of the brain. He famously discovered that the adult human brain can generate new nerve cells, a process called neurogenesis.
Salk has declared 2026 the Year of Brain Health. Learn more about how our scientists are exploring the brain's interconnectedness throughout the body — and how we can potentially make lives longer and healthier by improving brain function.
salk.edu/science/2026-the-sa…
#brainhealth #sciencefacts #neuroscience #salkinstitute
تم نشر جزء من أبحاثي في الدكتوراه في Communications Biology: أظهرنا أن الحموضة (pH منخفض) تعيد برمجة أيض الخلايا وتسبب خللًا في الميتوكوندريا وأزمة طاقة.
nature.com/articles/s42003-0…
فخور بهذا العمل، واشكر مشرفي والفريق البحثي وكاوست على الدعم. @Mo_Li_KAUST @KAUST_NewsAR
تم نشر جزء من أبحاثي في الدكتوراه في Cell Research: طورنا نموذج جنين بشري باستخدام جزيء صغير فقط دون بويضة مخصبة، وأظهرنا أن V-ATPase ضروري لتكوين الـblastocyst.
nature.com/articles/s41422-0…
فخور بهذا العمل، وشكرًا لمشرفي والفريق البحثي وكاوست على الدعم.
@Mo_Li_KAUST @KAUST_NewsAR
