@ScacheriLab

Epigenetics and human disease research lab at Case Western Reserve University School of Medicine -- Department of Genetics & Genome Sciences

scacherilab.gene.cwru.edu/
Joined May 2014
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13Media
Genome wide association studies have been used to identify genes that may be linked to opioid use disorder, but need hundreds of thousands of samples. @MeWantData & collaborators have developed a way to identify these genes, using a small # of samples: wi.mit.edu/news/opioids-and-…
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Epigenetic convergence in opioid overdose. Great to see this multi-team collaboration in print! Such a great group of people on this project. S. Akbarian, D. Mash, E. Johnson, D. Hancock, @ScacheriLab @Bun_Without_B nature.com/articles/s41380-0…
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TWEETORIAL on our new #radonc paper in @TheLancetOncol -- joint work from @CCLRI @MoffittNews @CWRUSOM 1/n Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis thelancet.com/journals/lanon… @OncoAlert
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Our studies are expanding from cancer into other major public health crises. Check out our latest on opioid use disorder. Team effort with Akbarian, Johnson, Mash, and @CorradinLab. biorxiv.org/content/10.1101/…

Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilit...

Opioid dependence is a highly heterogeneous disease driven by a variety of genetic and environmental risk factors which have yet to be fully elucidated. We interrogated the effects of opioid depend...

biorxiv.org
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Also, big thanks to Richard Sallari and the @axiotlinc team.
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Recruiting talented data scientists and molecular biologists to work on our newly funded project 👇🏼! This is our collective brainchild with ⁦@BullmanLab⁩ & ⁦@CJohnstonLab1⁩. Please retweet! Interested applicant please email [email protected] wmkeck.org/grant-programs/re…
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Fabulous ecDNA study by Henssen and Koche! Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma | Nature Communications nature.com/articles/s41467-0…

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Nature Communications - MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic...

nature.com
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This article is great! cen.acs.org/pharmaceuticals/…

The curious DNA circles that make treating cancer so hard

Scientists are examining long-ignored extrachromosomal DNA to understand how cancer evolves resistance to drugs. Can the clues help us outfox cancer itself?

cen.acs.org
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Evolutionary therapy is a new subfield in medicine (distinct from #evomed) that seeks to use our understanding of evolution to enable novel #cancer (& pathogen) therapy. Here we present the first link between #evotherapy and quantum physics. A #thread nature.com/articles/s41567-0…
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How does resistance to targeted therapy develop in #lungcancer? Is it pre-existence or a de novo mechanism? @AndriyMarusyk lab @MoffittResearch adds evidence for a truly Darwinian, gradual development from tolerant persisters to full resistance. A THREAD nature.com/articles/s41467-0…

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific...

Nature Communications - Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of...

nature.com
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Congrats to @CorradinLab!
Whitehead Institute@WhiteheadInst3 Apr 2020
Multiple sclerosis (MS) is considered an autoimmune disease. Researchers in the @CorradinLab led by @annAmbarbeau & the @TesarLab led by Daniel Factor found a role in MS for cells in the central nervous system—a potential new avenue for MS therapies: ow.ly/xUDc50z4sVb
Microscopy image of nerve fibers in red with oligodendrocyte cells in green

ALT Microscopy image of nerve fibers in red with oligodendrocyte cells in green

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Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! @morton_andrew #DamnProud
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To stop COVID-19, test everyone, repeatedly - Sten Linnarsson - Medium medium.com/@sten.linnarsson/…

To stop COVID-19, test everyone

This is a preprint, and has not been peer-reviewed.

medium.com
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Finished off with some historical sites in Jerusalem, including the western wall. Great tour with @caseccc colleagues including @ScacheriLab
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Excellent preview in @Cancer_Cell covering recent work on the role of extrachromosomal circular DNA in cancer, including our study in @NatureGenet with @anton_gh et al. Thank you for the highlight, Chris Ott. cell.com/cancer-cell/pdf/S15…
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A must read. Great work from Lupien Lab.
Mathieu Lupien@MatLupien23 Jan 2020
My team's latest publication deepening our understanding of the noncoding cancer genome: Noncoding mutations target cis -regulatory elements of the FOXA1 plexus in prostate cancer disq.us/t/3lj6ta2
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Scacheri Lab retweeted
Anton Henssen@anton_gh21 Dec 2019
Check out our first preprint! Together with @RichardKoche @CMskcc we show that MYCN amplicon structure is not only determined by local enhancers , as shown by @ScacheriLab @CellCellPress but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking.
bioRxiv Cancer Bio@biorxiv_cancer20 Dec 2019
Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma biorxiv.org/cgi/content/shor… #biorxiv_cancer
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Here’s a link to read and download for those without a subscription. Check it out! authors.elsevier.com/c/1a8FU…
Scacheri Lab@ScacheriLab21 Nov 2019
1/ So excited to have our work joint with the Rich lab lead by @morton_andrew published in Cell @CellCellPress today: “Functional enhancers shape extrachromosomal oncogene amplifications”. cell.com/cell/fulltext/S0092… #tweetorial below

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

Extrachromosomal oncogene amplification is a common occurrence across a broad range of cancers, yet the chromatin landscape of these high-level amplifications is poorly understood. Using a combinat...

cell.com
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ecDNA is hot! We encourage you to also read yesterday’s @nature paper lead by @mischellab @HowardYChang Bing Ren and Vineet Bafna. nature.com/articles/s41586-0…

Circular ecDNA promotes accessible chromatin and high oncogene expression

Nature - Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.

nature.com
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