Assistant Professor @Stanford University Genetics. Synthetic Biologist // Real Human 🧬 🔬 💻 🏳️🌈 🏊🏾♂️
San Francisco, CA
Joined January 2022
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🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
Kyle G Daniels retweeted
PSA: get your flu shot now if you haven't already
Using last year's flu trends as a template, from today we expect infection rates to double every 1.5 weeks, peaking ~2 months from now.
After vax, immunity takes 1.5 weeks to kick in, peaks at 1-2 months, decays after 3 months.
Kyle G Daniels retweeted
Pleased to share my lab’s new manuscript integrating genomics, drug development, cell biology, and mouse modeling to comprehensively evaluate the cyclin-dependent kinase CDK11 as a drug target in cancer.
Kyle G Daniels retweeted
Check out this exciting synthetic biology opportunity — designing multicellular circuits at the Allen Institute for Cell Science.
alleninstitute.org/careers/j…
Kyle G Daniels retweeted
We’re excited to share our new perspective in @MolecularCell on designing programmable biological behavior! (1/3)
doi.org/10.1016/j.molcel.202…
Kyle G Daniels retweeted
As an Editor, in past ~6mo, we are receiving an avalanche of unsolicited review articles (“scoping” “systematic”, narrative, NOS) on topics and ?s NO ONE EVER has asked and clearly with heavy AI lift. Even the cover letters all read the same…alarming and sad. #publishing
Kyle G Daniels retweeted
1. COMBINATORIAL STOICHIOMETRY: Regulators do not act alone, there is redundancy, competition, synergy & feedback. Knocking them down one by one is insufficient to learn the spectrum of regulatory effects (which is essential to generalize). 2/
Kyle G Daniels retweeted
The Keedy Lab at the CUNY ASRC in NYC is looking for a postdoc! Our lab uses avant-garde structural biology experiments and computational analyses to reveal conformational ensembles that underlie biological function. See attached flyer and keedylab.org. Please share!
ALT Keedy lab postdoc ad flyer with position details
Kyle G Daniels retweeted
Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. @DFCI_CancerBio
Read more: bit.ly/4hKLs46
Kyle G Daniels retweeted
Exciting news! Our team was selected to receive the @NIH Director's Pioneer Award!
Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?
The NIH Director’s High-Risk, High-Reward Research Awards empower innovative scientists redefining the limits of biomedical and behavioral research.
Meet the 2026 recipients of the NIH Director’s Pioneer, New Innovator, and Transformative Research Awards and discover the groundbreaking research they’re pursuing: go.nih.gov/BxJzhAG
ALT Three images are shown showing a DNA helix, a scientist, and lab equipment. The NIH Common Fund logo is also shown. Text reads: “Awards Announcement High-Risk, High-Reward Research”
Kyle G Daniels retweeted
We're hosting a small event to discuss the latest advances in AI and biology this Friday evening, featuring @arcinstitute researchers and others. Apply if interested! forms.gle/1fh1GpHrimqu1HkEA
Kyle G Daniels retweeted
getting old is insane. we found out last week my grandpa has cancer and the doctor was just like "he's 90 years old, he says it's not bothering him, we're just gonna leave it be, otherwise we'd make him miserable" and like. yeah he's kinda right
Kyle G Daniels retweeted
Delighted to share our paper led by Dr Mubin Tarannum in my lab #romeelab @DanaFarber showing how spatially restricted IL-12 in CAR NK cells leads to markedly enhanced tumor responses beating IL-15 and mediated through car and IL-12 signaling synergy through mTORC1
Now online: Spatially confined IL-12 programs CAR-NK through mTORC1 to coordinate antitumor immune networks doi.org/10.1158/2159-8290.CD…
Kyle G Daniels retweeted
Excited to share DR-GEM, a self-supervised computational framework for dimensionality reduction and clustering, and its application to single-cell and spatial transcriptomics. nature.com/articles/s41467-0…
Congrats to the team! @christineyyeh, who spearheaded this study, @DixianZhu, and @minwsun.
Here is a quick overview of the paper 👇 (1/11)
Kyle G Daniels retweeted
In the latest issue! Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function dlvr.it/TVdDXq
Kyle G Daniels retweeted
In a new @ScienceAdvances study, @SanjeevHerr, Shawn Hervey-Jumper, MD, @ToddCHollon, & their colleagues at @UCSF & @umichneuro present an AI model that predicts where #glioblastoma is likely to recur, paving the way for earlier, targeted interventions. science.org/doi/10.1126/scia…
ALT A graphic featuring headshot photos of Sanjeev Herr, MD, Todd Hollon, MD, and Shawn Hervey-Jumper, MD, the lead authors of a new publication over a stimulated Raman histology image of glioblastoma. Optical microscopy predictions of focal recurrence in glioblastoma. Herr et al. Sci. Adv. 12, eaec8202 (2026).
Kyle G Daniels retweeted
We're searching for an assistant/associate professor in Bioengineering at Stanford!
If you're using cutting-edge engineering approaches to understand or control biological systems in useful ways (medical, environmental, etc), we'd love to hear from you!
facultypositions.stanford.ed…
Kyle G Daniels retweeted
Beautiful work from Ron Weiss and team - a significant step forward for ML-driven design of synthetic circuits. biorxiv.org/content/10.64898…
Kyle G Daniels retweeted
Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
nature.com/articles/s41586-0…
Kyle G Daniels retweeted
Now online @NatureComms, our manuscript describing why the myeloma CAR T cell cilta-cel is more effective than a very similar CAR, ide-cel.
Led by the very talented Kevin Herrera and Sneha Mitra, and in collaboration with the Leslie Laboratory.
@MSKCancerCenter @szusmani
Kyle G Daniels retweeted
Brain cancers take advantage of neural circuit activity. Re-purposing an anti-seizure med called levetiracetam disrupts an important neuron-cancer interaction in #DMG #DIPG, slowing growth and extending survival in mice and retrospective patient data.
nature.com/articles/s41591-0…
