@ShohamLab

Neural engineer, Prof. @nyugrossman @nyuniversity. Making waves to bend, mend & understand perception. SPIE Fellow. #neurotech #biophotonics #focusedultrasound

 New York, NY
nie-lab.org
Joined June 2020
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Targeted Brain Ultrasound Could Help Relieve Schizophrenia Symptoms Low-intensity targeted #ultrasound could be an effective treatment for delusions in people with #schizophrenia or schizoaffective disorder @ShohamLab @nyugrossman #Alzheimersdisease hubs.li/Q04BTPdT0

Targeted Brain Ultrasound Could Help Relieve Schizophrenia Symptoms

Low-intensity targeted ultrasound could be an effective treatment for delusions in people with schizophrenia or schizoaffective disorder.

insideprecisionmedicine.com
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Excited to announce a powerful new one-two punch for voltage imaging from our lab and collaborators! In two new preprints, we introduce ASAP6c for high-throughput population spike-recording, and ASAP7yfor deep, subthreshold 2P imaging. 🧵 1/14
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Research by Drs. Dmitry Rinberg (@DimaRinberg) and Shy Shoham (@shohamlab) suggests “temporal filtering” may encode odor identity while suppressing background signals, raising new questions about sensory perception. Read more: nature.com/articles/s41593-0…
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Shy Shoham retweeted
David@dav1dcgMay 10
New voltage indicators from St-Pierre lab and collaborators: - FORCE1s: biorxiv.org/content/10.64898… - JEDI3sub and JEDI3hyp (image below): nature.com/articles/s41592-0… Blog post about voltage imaging: spikesandbursts.wordpress.co…
Figure 1.EDI3 indicators exhibit enhanced sensitivity to subthreshold voltages while maintaining comparable brightness and photostability as JEDI-2P in vitro. From: https://www.nature.com/articles/s41592-026-03043-8/figures/1

ALT Figure 1.EDI3 indicators exhibit enhanced sensitivity to subthreshold voltages while maintaining comparable brightness and photostability as JEDI-2P in vitro. From: https://www.nature.com/articles/s41592-026-03043-8/figures/1

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After literally a decade of effort from start to finish, our paper on the CaBLAM bioluminescent calcium indicator is finally published! Thanks to all who contributed to this massive undertaking ❤️ @LABrechaun @_theglowup @schoppik link.springer.com/article/10…

CaBLAM: a high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus...

Nature Methods - CaBLAM is a bioluminescent genetically encoded calcium indicator that delivers high-contrast signals as shown in cell culture, in the in vivo mouse brain and in zebrafish larvae.

link.springer.com
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🚨 Last chance to join us for an info session about #PhD training in biomedical imaging & tech at @nyugrossman: Nov 12, 5p ET via Zoom: nyulangone.zoom.us/meeting/r… #PhDlife #STEM #Admissions #science #engineering #AI #physics #medicine #health +@RicLattanzi @stbaete @NYUImaging 1/
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New @nyugrossman research shows, for the first time, that hologram-shaped focused ultrasound can activate brain circuits in live animals—offering promise for noninvasive brain disorder treatments. Published in @natBME Read more: nature.com/articles/s41551-0…
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Congratulations to our Chair, Dr. Kathryn Colby, on receiving the Cornea Society’s highest award, the Castroviejo Medal! Each year, this award is given in recognition of exceptional contributions in the field of cornea and anterior segment of the eye.
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Attending Photonics West? Join my course on 𝗽𝗵𝗼𝘁𝗼𝗮𝗰𝗼𝘂𝘀𝘁𝗶𝗰 𝗶𝗺𝗮𝗴𝗶𝗻𝗴, perfect for: 🔹 Beginners exploring the field 🔹 Researchers deepening their expertise ⏳ Early Bird discounts end Jan 10—don’t miss out! Details: tinyurl.com/2ns5skws #PhotonicsWest2025

SPIE Photonics West

spie.org
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(1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB biorxiv.org/content/10.1101/…

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

Neurochemical signals like dopamine (DA) play a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However,...

biorxiv.org
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Shy Shoham@ShohamLab19 Nov 2024
🧠🏙️Come join our budding community! Open rank Tenured/TT faculty positions in neural engineering at @NyuBme department of Biomedical Engineering. Highly recommended... 🔥 apply.interfolio.com/159320
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In today's House appropriations committee hearing on the HHS budget, @NIHDirector defended the BRAIN initiative, along with the other programs funded by the 21st century cures act, as "critical": "We cannot let them die."
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Online now on biorxiv: our new voltage indicator engineered for red 2P optical recordings, 2Photron. Only possible thanks to great collaborators @ERSchreiter,@DieudonneLab,@PodgorskiLab, and others! biorxiv.org/content/10.1101/…

A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP...

Genetically encoded voltage indicators (GEVIs) allow optical recording of membrane potential from targeted cells in vivo . However, red GEVIs that are compatible with two-photon microscopy and that...

biorxiv.org
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🙋🏾‍♀️🙋🏽‍♂️🙋🏻‍♀️ Join us for a virtual info session about @nyugrossman's #PhD program in biomedical imaging & technology! 🗓️ Thursday, Nov 14, at 10 am ET 📝 Register at nyulangone.zoom.us/webinar/r… 🎓 More info: med.nyu.edu/research/vilcek-… CC: @RicLattanzi @stbaete @dimanovikov @CarIanniello
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Shy Shoham retweeted
Neuron@NeuroCellPress9 Oct 2024
Check out our new issue: cell.com/neuron/current Cover is for @Keith_jonez and colleagues' #NeuroResource on optimized ultrasound neuromodulation for non-invasive control of behavior and physiology in mice. Find it here: cell.com/neuron/fulltext/S08…
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Shy Shoham retweeted
Max Hodak
@maxhodak_22 Oct 2024
I'm super excited to share some results from the Science PRIMA retinal prosthesis clinical trial, including that it's exceeded its main efficacy endpoint with a mean acuity improvement of 4.6 EDTRS lines. Trial participants are almost completely blind due to macular degeneration. There are no good options available to these patients today.
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Very sad to hear about the passing of Yves Fregnac - an original thinker who published important work on V1 selectivity & shunting inhibition and, later, on the changing culture of neuroscience research, which we discussed widely during Capocaccia meetings science.org/doi/10.1126/scie…

Big data and the industrialization of neuroscience: A safe roadmap for understanding the brain?

New technologies in neuroscience generate reams of data at an exponentially increasing rate, spurring the design of very-large-scale data-mining initiatives. Several supranational ventures are...

science.org
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If you are interested in deep brain 2p imaging, check out our new work on aberration-corrected long microendoscopes (length > 6 mm)! Published as a Reviewed Preprint in @eLife! Thanks to all the authors! elifesciences.org/reviewed-p…
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I apologize if our previous preprint post was taken as if the original results were irreproducible. The skin clearing was reproduced. Although other issues remain, we decided to retract our preprint. I apologize to @HongNeuroTech and the community for the confusion.
Takeshi Imai@TakeshiImaiLab29 Sep 2024
Check out our new bioRxiv preprint that challenges the recent in vivo optical clearing paper with tartrazine dye in Science. To be clear, they only demonstrated optical clearing of *dead cells*. Tartrazine cannot make live tissues transparent doi.org/10.1101/2024.09.29.6…
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🧪A team of researchers, led by @HelenFarrants & @ERSchreiter, developed a new way for engineered protein biosensors & bright, fluorescent Janelia Fluor dyes to work together, creating a new biosensor for measuring physiological signals in live animals.➡️janelia.org/news/new-biosens…
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