@ShuaiFu2

Postdoctoral Fellow at Salk Institute for Biological Studies

 San Diego
Joined April 2018
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  • Following173
  • Followers45
Excited to share that the second piece of my PhD work at Wynshaw-Boris lab in close collaboration with Dr. Luke Bury is out!👉
Cell Reports@CellReports14 Oct 2024
Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of neuronal production, diversity, and disease dlvr.it/TFLFTM

Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of...

Bury et al. utilize genetic lineage tracing to determine the progenitor lineage of neurons in human cortical organoids. They find most glutamatergic neurons are produced through intermediate progen...

cell.com
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What distinguishes successful from failed reprogramming to iPSC? In this new preprint, part of our @IGVFConsortium efforts, we used single cell methylation, Hi-C, RNA and ATAC, and spatial RNA to answer this question biorxiv.org/content/10.64898…
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Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of neuronal production, diversity, and disease dlvr.it/TFLFTM

Neuronal lineage tracing from progenitors in human cortical organoids reveals mechanisms of...

Bury et al. utilize genetic lineage tracing to determine the progenitor lineage of neurons in human cortical organoids. They find most glutamatergic neurons are produced through intermediate progen...

cell.com
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Replying to @JoeEcker
@JoeEcker, @ecallaway, Margarita Behrens, and team have produced the most detailed atlas ever of the diversity and connections of neurons in the mouse brain 🧠 Their work is featured in a 10 paper BRAIN Initiative package in @Nature #BICCN #studyBRAIN salk.edu/news-release/salk-t…
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ResearchGPT is a custom GPT especially designed for researchers. It has a database of 282 million research articles and it answers your questions with references to published articles. No fake citations. Here's how to use it:
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It's finally out in Nature Biotechnology. nature.com/articles/s41587-0… We developed single cell m6A RNA modification mapping technology for studying m6A in vivo in single cells and scarce cell types without specialized laboratory equipment.

Single-cell m6A mapping in vivo using picoMeRIP–seq

Nature Biotechnology - A picogram-scale m6A mapping method is applied to single mouse oocytes and embryos in vivo.

nature.com
Nature Biotechnology
@NatureBiotech22 Jun 2023
Single-cell m⁶A mapping in vivo using picoMeRIP–seq go.nature.com/43YPbTF
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New preprint from Wynshaw-Boris lab, Carried out by our excellent postdoc Luke Bury and me😀, see link👉 Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of human neuronal production, diversity, and disease biorxiv.org/content/10.1101/…

Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of...

The contribution of progenitor subtypes to generate the billions of neurons during human cortical neurogenesis is not well understood. We developed the Cortical ORganoid Lineage Tracing (COR-LT)...

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Applying this lineage tracing in an isogenic pair of autistic iPSC allowed us to identify that an autism spectrum disorder-specific CTNNB1 stop-gain variant led to altered lineage-specific neuronal production and transcriptional differences.(4/5)
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Our results suggest individual progenitor subtypes play unique roles in generating the diverse neurons of the human cerebral cortex.(5/5)
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thedaily.case.edu/meds-antho…
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A new study suggests that in addition to exploring the effects of known autism-linked mutations, researchers should assess the potential mediating effects of the rest of a person’s genome. How will you use this insight in your research? By @cqchoi. bit.ly/3Ohnkcp
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@girirajan16 @ShuaiFu2
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Shuai Fu retweeted
AJHG@AJHGNews25 Apr 2023
💫 OUT NOW @AJHGNews 📰 Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis 🧑‍🤝‍🧑 @ShuaiFu2 & team 👇 bit.ly/3oK3ADk
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My PhD thesis work on autism risk gene PTEN is out @AJHGNews, Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis. Check it out! 👉 authors.elsevier.com/c/1gzV8…
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We performed bidirectional genome editing on iPSCs derived from individuals with autism and controls.
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We uncovered that the PTEN p.Ile135Leu variant, found in an ASD-affected individual with macrocephaly, dysregulated cortical neurogenesis in an ASD-genetic-background-dependent fashion by using 2D neural progenitor cells and 3D cortical organoids.
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#PLOSONE: The Molecular Medicine PhD program alumni perceptions of career preparedness dx.plos.org/10.1371/journal.…
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