The Spangler Lab at Johns Hopkins University integrates structural biology, molecular engineering, and translational immunology to design new disease therapies.
Baltimore, MD
Joined May 2018
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Thrilled to share our new article in @acsnano
on the use of a hydrogel-based platform developed by the lab of @dinodicarlo for immune phenotyping at the single cell scale: doi.org/10.1021/acsnano.4c18…
Delighted to share our new article in @MolTherapy on novel bispecific VEGF antagonist proteins for treatment of eye diseases:
sciencedirect.com/science/ar…
Thrilled to share our new collaborative research on CAR NK cell engineering with @BonifantLab just published in JITC:
jitc.bmj.com/content/13/2/e0…
Excited to share our lab's new review article in @trendscancer, surveying recent work in engineering growth factor systems to advance cancer therapy:
cell.com/trends/cancer/fullt…
SpanglerLab retweeted
Exciting news! #HopkinsBME research landed the cover of @JCI_insight for September.
A complex approach for antitumor activity: insight.jci.org/articles/vie…
The Cover features study by Elissa Leonard, Jakub Tomala et al. They engineered a cytokine/antibody fusion protein with important implications for future immunocytokine development.
@SpanglerLab @HopkinsMedicine
So honored to have our cytokine/antibody fusion protein work featured on the cover of @JCI_insight! Huge thanks to Ann Seliger for the beautiful illustration. insight.jci.org/9/18
Excited to share our latest work by Elissa Leonard, Jakub Tomala, and colleagues on the the design of cytokine/antibody fusion proteins for cancer immunotherapy published in @JCI_insight!
insight.jci.org/articles/vie…
Thanks so much to Gordana Wozniak and Veronica Natale at BOKU University for this fantastic preview article!
SpanglerLab retweeted
👀Preview of Ludwig et al.: Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1 by Gordana Wozniak-Knopp and Veronica Natale at @BOKUvienna @acibGmbH dlvr.it/T6znCd
Thrilled to share that Dr. Spangler has been promoted to Associate Professor with Tenure in the departments of Biomedical and Chemical & Biomolecular Engineering at Johns Hopkins. Deeply grateful for the trainees, mentors, colleagues, and collaborators who made this all possible!
Congratulations to Jakub Tomala and Shanelle Cao on their new review article on anti-cytokine antibodies in Journal of Immunology @J_Immunol!
doi.org/10.4049/jimmunol.230…
So honored to have Dr. Aliyah Silver's @CellRepMed article featured by @TheVFoundation this week! #VictoryOverCancer #CancerResearch
SpanglerLab retweeted
Check out my latest article: I’m stuck on how great this research is! linkedin.com/pulse/im-stuck-… via @LinkedIn
SpanglerLab retweeted
Jan '24 #Workshop #Advances in #Immunoengineering! FREE Registration
jhtie.jhmi.edu/training-upco…
Exciting speakers include:
@scienceempress
@JennyNJiang
@michal_bassani
Dan Campbell
Sharon Gerecht
& more!
@NIBIBgov
@HopkinsMedicine
@HopkinsEngineer
@INBT_JHU
@JHUBME
@TTECJHU
Congratulations to Luke Tomasovic (@luketomasovic11), Kathy Liu, Dr. Derek VanDyke, and Charina Fabilane on their new review article on IL-2 therapies for autoimmune diseases out in @BioDrugsJournal!
doi.org/10.1007/s40259-023-0…
Delighted to share recent PhD laureate Dr. Aliyah Silver's new article on engineering a tumor-targeted cytokine/antibody fusion protein in @CellRepMed! Thanks to @JGreenGroup and @jishiharalab for working together with us on this story. doi.org/10.1016/j.xcrm.2023.…
Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry!
@jbiolchem
doi.org/10.1016/j.jbc.2023.1…
Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry! @jbiolchem
doi.org/10.1016/j.jaut.2023.…
So excited to be a part of the Rice University ARPA-H team led by @veiseho to develop a new device for targeted tumor treatment: arpa-h.gov/news/baa-cancer/.
