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Joined August 2010
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Steve Springer MD Senior Partner Imperial Health retweeted
Today @KarlDeisseroth of @StanfordMed @Stanford won the @NobelPrize for his co-discovery & development of Optogenetics. Here he explains what that is, and how it is unlocking the secrets of brain function & helping to cure diseases.
(And he explains that in ~1min).
Steve Springer MD Senior Partner Imperial Health retweeted
Spanish scientist Mariano Barbacid and his team have achieved something remarkable: for the first time, they’ve completely cured pancreatic cancer in mice using a triple therapy that eradicated the tumors without triggering resistance.
This is one of the most aggressive cancers in humans, and this breakthrough is being celebrated as a major step forward. The real challenge now is moving it from mice to people.
The therapy combines three targeted agents to block key cancer survival pathways; it is currently in the preclinical (mouse model) stage, with plans to advance to human clinical trials as soon as funding allows.
If you’ve lost someone to pancreatic cancer — or simply want to support turning lab hope into real treatment — this is a moment worth paying attention to.
Humanity needs breakthroughs like this.
Steve Springer MD Senior Partner Imperial Health retweeted
🚨The CEO of Coinbase just said something nobody's taking seriously enough.
AI agents will outnumber humans in transactions. Soon.
> "They can't open bank accounts. No ID. No SSN. Banks literally cannot serve them."
> "But they already own crypto wallets."
So the biggest economy of the next decade won't run through banks at all. It'll run through blockchains. Not because crypto won. Because banks physically can't onboard a customer that isn't human.
Banks weren't built for what's coming.
Steve Springer MD Senior Partner Imperial Health retweeted
With the E – 2D Hawkeye circling above the Gulf of Oman at 20,000 feet the Iranian Salvo of 52 assorted missiles didn’t make a scratch on the Abraham Lincoln carrier strike group. This United States Navy surveillance aircraft can monitor threats as far as 500 km.
- Iran launched a coordinated attack of 52 missiles targeting the USS Abraham Lincoln aircraft carrier strike group in the Gulf of Oman at approximately 2:23 AM.
- Missile breakdown:
- 28 × Ghadr Fars anti-ship ballistic missiles.
- 16 × Emad medium-range ballistic missiles.
- 8 × Hormuz-2 anti-radar missiles.
- Detection: An E-2D Advanced Hawkeye airborne early warning aircraft (flying at ~25,000 feet) detected all 52 inbound missile tracks during their boost phase using its AN/APY-9 radar.
- Response time: The Hawkeye crew identified and cataloged the threats in under 40 seconds, then transmitted firing assignments via Link 16 data link.
- Interception: The USS Abraham Lincoln carrier strike group (using Naval Integrated Fire Control Counter Air - NIFC-CA architecture) engaged via Aegis combat systems on Arleigh Burke-class destroyers (specifically named: USS Frank E. Petersen Jr., USS Pruance, USS Michael Murphy).
- Outcome: All 52 missiles were successfully intercepted within eight minutes; no impacts on the carrier or group.
- Additional context in narration:
- Iran's missile arsenal was significantly depleted/weakened by prior Israeli strikes in June 2025.
- Iranian media/claims of a successful hit or damage to the Lincoln are dismissed as false propaganda.
Steve Springer MD Senior Partner Imperial Health retweeted
The most valuable skill in history just changed forever.
Elon Musk just handed you the only survival framework that matters.
Musk: “The biggest thing is, what questions do we not know to ask?”
For centuries, the smartest person in the room held the most answers.
AI didn’t level the playing field. It burned it down.
Superintelligence in your pocket answers anything. Instantly. Perfectly. For free.
Musk: “Once you know the question, the answer is usually the easy part.”
Let that land.
The next generation of winners won’t be defined by what they know. They’ll be defined by what they think to ask.
AI commoditized execution.
Script, plan, code, strategy. Models handle all of it.
The bottleneck was never intelligence. It was never labor. It’s curiosity. It’s always been curiosity.
Traditional education spent decades training you to memorize answers. AI made that obsolete overnight.
Human value is no longer tied to knowledge. It’s tied to the judgment of which problems are even worth solving.
That’s the gap machines can’t close.
Because asking the right question isn’t a skill. It’s a worldview.
It requires taste. Intuition. The ability to look at a landscape everyone else is staring at and see the one thing nobody thought to interrogate.
Master the art of asking the exact right question to a machine that knows everything and you can build anything.
The skill isn’t knowing. It’s knowing what to ask.
That judgment, that taste for what’s worth pursuing, that’s the last truly human edge. The only one markets will keep paying for.
Answers are infinite now. Free, instant, and available to everyone on earth equally.
The only thing separating you from the person who builds the next great company is the quality of your questions.
Answers are free. Questions are everything.
Steve Springer MD Senior Partner Imperial Health retweeted
I’ll share a small part of pickle.com
Back in med school, I became obsessed with augmenting memory and dreamed of a Notion or Obsidian that completes itself. Today, we’ve built something close.
My self-awareness is sharper and everything feels connected. I genuinely believe AI does not replace humans. It amplifies us.
Huge respect to our engineers and designers who made this crazy thing real.
Bubbles are the episodic units of my life that the system interprets from my raw data. Clouds are the system’s questions, its hypotheses about who I am.
When I answer a cloud, it becomes a bubble again.
There is so much personal data that I cannot fully demo it. Wish I could. This system understands me more deeply than anyone.
Want to try it? Retweet and comment “memory.”
I’ll DM you an access code to skip the waitlist.
Steve Springer MD Senior Partner Imperial Health retweeted
Today in 1945, George Orwell published a devastating critique of Communism.
Animal Farm reveals why every communist revolution follows the same tragic pattern: liberation to corruption to oppression.
Here are 10 truths from Animal Farm Orwell warned us never to forget 🧵👇🏼
Steve Springer MD Senior Partner Imperial Health retweeted
🧵 (1/3) Excited to finally share our creatine pilot trial in AD results! We found that 20 g/day creatine monohydrate for 8 weeks was safe and feasible in people with AD. Compliance was excellent, and serum creatine significantly increased.
Steve Springer MD Senior Partner Imperial Health retweeted
Source: cnn.com/2024/11/28/health/th…
Steve Springer MD Senior Partner Imperial Health retweeted
The people of America gave @realDonaldTrump a crystal clear mandate for change tonight
Steve Springer MD Senior Partner Imperial Health retweeted
Good history discussion
Here's my conversation with Gregory Aldrete, a historian specializing in ancient Rome and military history.
We talk all about the Roman Empire: its rise and fall, major battles & leaders, military technology & tactics, gladiators, politics, laws, economy, religion.
I will do many more episodes on history (interviews & solo). If we don't understand our past, we are doomed to repeat the same mistakes that many before us have paid a heavy price for.
Timestamps:
0:00 - Introduction
2:23 - Ancient world
16:18 - Three phases of Roman history
19:08 - Rome's expansion
30:48 - Punic wars
39:20 - Conquering Greece
40:59 - Scipio vs Hannibal
44:05 - Heavy infantry vs Cavalry
47:42 - Armor
1:00:32 - Alexander the Great
1:06:33 - Roman law
1:16:13 - Slavery
1:23:53 - Fall of the Roman Republic
1:27:38 - Julius Caesar
1:32:17 - Octavian's rise
1:42:09 - Cleopatra
1:50:32 - Augustus
2:18:42 - Religion in Rome
2:42:47 - Emperors
2:49:54 - Marcus Aurelius
2:56:05 - Taxes
2:59:13 - Fall of the Roman Empire
3:16:25 - Decisive battles
3:40:35 - Hope
Steve Springer MD Senior Partner Imperial Health retweeted
Focused Ultrasound: A post-scalpel future in which high-frequency sound waves augment & advance Rx for more than 170 medical afflictions-- from plantar fasciitis to Alzheimer’s, Parkinson’s, drug addiction & several types of cancer. @FUSFoundation
bloomberg.com/news/features/…
Steve Springer MD Senior Partner Imperial Health retweeted
Neil Gaiman's Most Important Rule for Writing
cc: @neilhimself
Steve Springer MD Senior Partner Imperial Health retweeted
AI is unraveling new scientific laws. Soon enough, biology will intersect with technology in ways we can't even IMAGINE yet.
Steve Springer MD Senior Partner Imperial Health retweeted
Proposed law: if someone tears down the American flag and puts up another flag in its place, that person should get a free (but mandatory) one-way trip to that flag’s country
80%Yes
20%No
1,492,651 votes • Final results Steve Springer MD Senior Partner Imperial Health retweeted
"I hate writing - but I love having written."
Thanks for that great reminder @hughhowey
at @timferriss Podcast.
Great episode for all writers out there.
youtube.com/watch?v=j8WCRFct…
Steve Springer MD Senior Partner Imperial Health retweeted
Three publications in the past 3 months on effects of NMN in humans: improved walking speed, lower lipid levels, cholesterol, blood pressure and reduced aging rate. Honored to be part of study 2 @BrighamWomens @harvardmed ⬇️ 1/3
iubmb.onlinelibrary.wiley.co…
