Laboratory of Comparative Developmental Dynamics, Department of Genetics, University of Cambridge
University of Cambridge
Joined April 2017
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Its been busy! Three new preprints all on @biorxivpreprint :
馃悷Notochord Mechanics in Axis Elongation: tinyurl.com/3au7azp2
馃悹Live Modelling GRNs on Real Tracking Data in the PSM: tinyurl.com/knw8mm6x
馃悺Compression-Extension in the PSM: tinyurl.com/jye9xamw
What a year. Thank you to all our colleagues @GeneticsCam and @Cambridge_Uni for keeping our labs open and keeping us safe. Have a wonderful Christmas everyone!
Congratulations!
Quite happy to announce that I received DFG's Walter Benjamin Postdoc fellowship today. With all the support from @BenSteventon2 , it has been a wonderful experience to write a fellowship application. Thank you @dfg_public . I left Germany a while ago but Germany hasn't left me.
ALT Good to hear nice things about the proposal from the reviewer himself/herself.
This work was initiated by @andattardi @viktri08 who also produced the #SPIM data with @LabTrivedi. Thanks to @dd_chaitanya and @AMA_Lab @AMartinezArias for continuing collaborations @GeneticsCam.
By revealing a role for elongation in controlling the temporal exposure of cells to patterning signals, this work supports a role for tissue tectonics in the multi-scale regulation of developmental timing, recently reviewed by @Larabeeee tinyurl.com/y9wdjtdd
Lastly, we demonstrate that pattern formation is regulated by morphogenesis. By blocking morphogenesis, we prevent separation of anterior and posterior signalling domains and so do not get full AP patterning.
We also disaggregate and reaggregate a full pescoid and still see mesoderm formation. If we reaggregate all the cells, we even get elongation. These three results together mean prepattern cannot be responsible for elongation
We show that labelling the edge of an explant, or the marginal zone prior to cutting a #Pescoid, results in labelled cells spread across the entire explant before elongation occurs.
Here we show that this process is robust to a continual spatial disruption of this early polarisation, suggestive of an inherent self-organising process. We demonstrate this in 3 ways
Explants of early embryonic cells from teleost embryos are known to spontaneously break morphological symmetry and elongate (Oppenheimer, 1936; tinyurl.com/y9olfb6a).
