@SynGenome

International team building the world's first designer eukaryotic genome...thinking about what's next...Synbio enthusiasts. Tweets by Sc2.0 consortium members

syntheticyeast.org
Joined February 2015
  • Tweets1.3K
  • Following716
  • Followers1.5K
77Media
Thank you for highlighting this @TwistBioscience - hope you are keen on many more synthetic chromosome/genome projects!
Twist Bioscience@TwistBioscience20 Nov 2023
The work developing a synthetic yeast genome, Sc2.0, is a landmark for #synbio. We are thrilled that @TwistBioscience DNA was used to support the effort: “Design, construction, and functional characterization of a tRNA neochromosome in yeast” bit.ly/3R5q2m9
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A yeast strain with over 31% synthetic genome displays normal morphology and budding behavior >>> bit.ly/47pzsPr @CellPressNews @JefBoeke @caiyizhi @SynGenome
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Scientists @BABlount @UoNLifeSci & @ProfTomEllis @Imperialcollege are poised to create the most advanced “synthetic” organism ever made — a baker’s yeast that is controlled entirely by human-made genetic instructions. Read more @thetimes ▶️ ow.ly/hTEb50Q6nZ9
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Congrats to the Sc2.0 community on this huge achievement. Just wait for our Oxytricha trifallax 2.0!!
Tom Ellis@ProfTomEllis8 Nov 2023
Happy Sc2.0 day. 10 new papers published today in Cell Genomics, Cell and Molecular Cell. Telling the story of 8 more completed chromosomes (including ours) and a tRNA neochromosome and bringing more than half the syn genome together into a single cell. cell.com/cell-genomics/curre…
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Now online! Design, construction, and functional characterization of a tRNA neochromosome in yeast dlvr.it/Syc6fM
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We finally finished our synthetic chromosome! @ProfTomEllis @glen_gowers I'm just going to collapse in this corner now... cell.com/cell-genomics/fullt…

Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular...

Blount et al. describe completion of the synthetic Saccharomyces cerevisiae chromosome XI and identify redesigns to non-coding regions as essential to achieve strain fitness equivalent to the wild...

cell.com
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A strain of yeast has had half its DNA replaced with artificial chromosomes in a major step towards creating the first complex cell with an entirely synthetic genome newscientist.com/article/240…

Yeast has half its DNA rewritten in quest for synthetic complex cells | New Scientist

A team aiming to produce the first complex cell with an entirely synthetic genome has created a strain of yeast with half of its chromosomes designed from scratch

newscientist.com
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Now online! Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions dlvr.it/SyZRQf

Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interact...

Multiple synthetic chromosomes in Sc2.0 were consolidated together into a single yeast strain, revealing combinational genetic interactions through CRISPR D-BUGS.

cell.com
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Researchers have achieved a significant milestone by successfully integrating more than seven synthetic chromosomes into a single yeast cell, yielding a strain with over 50% synthetic DNA that can survive and replicate similarly to wild yeast strains: synbiobeta.com/read/its-aliv…
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It’s a great pleasure to see the tRNA neochromosome finally reaching the light of day at @CellCellPress! I’m sharing co-first authorship with @DSchindler_PDR, with @caiyizhi at the helm and under the guidance of @JefBoeke. Find the article here: sciencedirect.com/science/ar…
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Congratulations to all the consortium members for their hard work and contributions towards a landmark achievement in synthetic biology! @PaulsenLab @SynGenome
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How do you build a synthetic yeast genome with thousands of designed changes and a new-to-nature genome diversification ‘scramble-ing’ mechanism?
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Sc2.0 retweeted
nature
@Nature8 Nov 2023
Biologists have produced a strain of yeast whose genome is more than 50% synthetic DNA go.nature.com/3Qtp2a3

Engineered yeast breaks new record: a genome with over 50% synthetic DNA

Nature - Highly edited strain survives and replicates despite containing 7.5 artificial chromosomes.

nature.com
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“Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast” @CellGenomics cell.com/cell-genomics/fullt… @caiyizhi

Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic...

By construction and SCRaMbLE of a synthetic disomic yeast (n + synVII), Shen et al. discovered that both chromosome copy number and specific chromosomal regions (five genes on synVII) contribute to...

cell.com
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“Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast” @cellcellpress cell.com/cell/fulltext/S0092… @caiyizhi

Design, construction, and functional characterization of a tRNA neochromosome in yeast

A designer tRNA neochromosome containing all 275 nuclear tRNA genes of Saccharomyces cerevisiae reveals unexpected genomic plasticity and insights into both tRNA and chromosome biology.

cell.com
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#Yeast cell created with an over 50% synthetic #genome can survive and replicate similar to wild type. See below a collection of papers presenting this half-synthetic yeast and showcasing the #SyntheticYeastGenomeProject (Sc2.0) @yeastgenome 🧵
Scanning electron micrographs of the syn6.5 strain of yeast which has ~31% synthetic DNA and displays normal morphology and budding behavior. Cell, Zhao et al.

ALT Scanning electron micrographs of the syn6.5 strain of yeast which has ~31% synthetic DNA and displays normal morphology and budding behavior. Cell, Zhao et al.

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Very proud of our November issue presenting the amazing work by the Sc2.0 consortium. Took me back to my #igem (2006) roots and I know this collection will be a landmark in synthetic biology. cell.com/cell-genomics/curre…
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Check it out now in #Cell #Genomics Open Access - Rise of synthetic #yeast: Charting courses to new applications community.alliancegenome.org…
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“Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains” @CellGenomics cell.com/cell-genomics/fullt… @JohnsHopkinsSPH Srinivasan Chandrasegaran @JefBoeke @WEIMINZHANG6

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast...

McCulloch et al. describe complete synthesis of synIX and dissect a bug resulting from tRNA deletion upstream of telomerase-related EST3 at the protein, RNA, and telomere length levels. A new genetic...

cell.com
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An international team of scientists led by @caiyizhi are one step closer to re-writing world’s first synthetic yeast genome. The Sc2.0 team have now recreated every chromosome in baker's yeast from scratch and combined 6.5 of them in a functional cell. 👉manchester.ac.uk/discover/ne…
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