@TheGenomeLab

Group Leader of the Genome Function Laboratory @TheCrick From 2025, find me over on the other side: https://xitter.cf/t.co/ajOqpCvaUY (he/him)

 London
crick.ac.uk/research/labs/greg-findlay
Joined July 2011
  • Tweets280
  • Following294
  • Followers1.2K
39Media
Join us for a PhD! Applications close November 5th. crick.ac.uk/careers-study/va…
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New from our lab @TheCrick , led by @BetkaRoe. A fun side project that tried to understand what happens when a chaperonin encounters a translating ribosome. biorxiv.org/content/10.1101/…
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Come join us in making agriculture sustainable at @PhytoformLabs! 🌱We are looking for an R&D scientist with a background in Synthetic biology to join our tools & traits team for precision genome editing 🧬. If you think this could be you, please apply! linkedin.com/jobs/view/39723…

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So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in @Nature nature.com/articles/s41586-0… 🧵 1/16

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Nature - The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′...

nature.com
Yuyang Chen@quenchentin11 Jul 2024
(1/4) I’m delighted to announce that our research on RNU4-2 is now out on @Nature . This is an exciting finding that will bring many diagnoses worldwide. We have updated some new results since the preprint: nature.com/articles/s41586-0…

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Nature - The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′...

nature.com
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We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-09_…
"The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

ALT "The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

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Want to fully investigate this large dataset beyond classical 2D formats? Go interactively explore the data 👇 vhl-board.onrender.com/
Greg Findlay@TheGenomeLab5 Jul 2024
Replying to @TheGenomeLab
The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com/ Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)
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Our DNA Typewriter protocol (written by @LiaoHanna, @JShendure, and myself) is out! Thank you @NatureProtocols for writing/editing this with us and having it as this week’s #FeaturedProtocol :-)
Nature Protocols@NatureProtocols11 Jun 2024
#FeaturedProtocol this week from Jay Shendure on using #DNATypewriter (#primeediting-based method) for tracing insertional events bit.ly/4cegahU
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Happy to share this opportunity to join our team. Please apply if you are interested, or re-post if you are not on the look out for a new job crick.wd3.myworkdayjobs.com/…
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Excited to see our work on the development of a platform for pooled screening of genetic variants using prime editing published on @biorxivpreprint: doi.org/10.1101/2024.04.01.5….
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Greg Findlay retweeted
Alex Cagan@ATJCagan13 Jul 2023
Phoebe Dace on using saturation genome editing to understand the functional effects of BRCA1 variants #VariantEffect23
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Greg Findlay retweeted
Mike Devine@NeuroMikeD22 Mar 2023
Yes, mitochondria can jump from cell to cell🤯 Ever wondered how they do this? And how we might be able to harness this to treat disease? If so, apply below👇 Deadline in two weeks📅
Mike Devine@NeuroMikeD24 Feb 2023
🚨Job alert!🚨 How do mitochondria shuttle between neurons and astrocytes, and why? We are looking to recruit a postdoc to work on these exciting questions @TheCrick with @MSDintheUK 🧠🔬 Please RT! 🙏 Informal enquiries welcome crick.wd3.myworkdayjobs.com/…
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Greg Findlay retweeted
Mike Devine@NeuroMikeD24 Feb 2023
🚨Job alert!🚨 How do mitochondria shuttle between neurons and astrocytes, and why? We are looking to recruit a postdoc to work on these exciting questions @TheCrick with @MSDintheUK 🧠🔬 Please RT! 🙏 Informal enquiries welcome crick.wd3.myworkdayjobs.com/…
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Join us for a PhD in the Protein Biogenesis lab @TheCrick ! We have a very exciting project aimed at understanding how human cells orchestrate the folding of different proteins at the ribosome. crick.ac.uk/careers-study/va…
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📢Apply now to the Crick PhD programme🚨we have an open position in the targeted protein degradation & antibiotic research laboratory💊🦠join us! 🏃deadline: 22 March crick.ac.uk/careers-study/st…

PhD student recruitment

PhD recruitment is now open until 3 November.

crick.ac.uk
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👀 Looking for something to do this week? Why not stop by our brand new exhibition #CutAndPaste, created with @TheLiminalSpace, to explore the big questions around the ethics of genome editing 📅 Thurs-Sat 10AM - 4PM 📅 Wed 10AM - 8PM ☕ Public café 🔗 ow.ly/atvj50MU0Q3
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Tired of battling with noisy single-cell datasets? spinDrop to the rescue! We implement a sensitive droplet microfluidic system that discards empty droplets, cell multiplets and damaged cells from the sequenced dataset using droplet sorting. A 🧵(1/11) biorxiv.org/content/10.1101/…

spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content

Droplet microfluidic methods have massively increased the throughput of single-cell sequencing campaigns. The benefit of scale-up is, however, accompanied by increased background noise when process...

biorxiv.org
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Would you edit your DNA? Which diseases should we try to avoid or treat, and who decides? 🧬✂️ Explore the big questions around genome editing in our upcoming exhibition, Cut + Paste. 📆 Take part in person and online from 11 February 2023 ow.ly/ybpS50LFG7g
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🦠 Want to identify processes enabling pathogenic bacteria to become resistant to antibiotics? 💊 Want to chemically interfere with these processes? 🔬 Want to do this in London, @TheCrick? 👋 Then join my lab! We’re recruiting 2x 4-year postdocs. crick.wd3.myworkdayjobs.com/…
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💡 There are only a few days left to apply to our PhD programmes! 🔹 Applications to our PhD programme are open until Thursday this week ➡️ ow.ly/oaVa50LvVOK 🔹 Applications to our PhD programme for clinicians are open until Tuesday 15 November ⤵️ ow.ly/CcHv50LvVOL
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Want to study how cancer evolution and cellular plasticity drive drug resistance using statistical modelling, bioinformatics and machine learning approaches? We have a postdoc position available, 1 week left to apply: tinyurl.com/2p9n5ssx Please RT.
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