Was told I’m useless. So I’m testing the theory. 🧪
In the lab 🧪
Joined June 2019
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The Lab Guy retweeted
“The Transition”: the period of time during which the global economy and social structure will be reinvented as a result of SI. 2027-2032. it will be rough.
The Lab Guy retweeted
NAD+–sirtuin–mitochondrial quality control in lens epithelial cells: a candidate modulatory network in crystalline lens aging
sciencedirect.com/science/ar…
The Lab Guy retweeted
🚨 Scientists Removed the Extra Chromosome Linked to Down Syndrome Using CRISPR!
What if scientists could remove the extra chromosome responsible for Down syndrome? Japanese researchers have just demonstrated that this may be possible.
In a groundbreaking study, scientists at Mie University used CRISPR-Cas9 gene-editing technology to target and remove the extra copy of chromosome 21 from human cells carrying the genetic condition.
But the results were even more interesting. After removing the extra chromosome, researchers observed improvements in gene activity, cell growth, and other signs of cellular health.
The biggest catch? This experiment was conducted on cells in a laboratory, NOT in people. It is not yet a treatment or cure for Down syndrome, and major safety challenges remain.
Still, this discovery opens an exciting new door in genetic research. Could scientists one day correct chromosome abnormalities at their source?
Source:
Hashizume, R., et al. (2025). Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells. PNAS Nexus, 4(2), pgaf022.
ALT Scientists Removed the Extra Chromosome Linked to Down Syndrome Using CRISPR! What if scientists could remove the extra chromosome responsible for Down syndrome? Japanese researchers have just demonstrated that this may be possible. In a groundbreaking study, scientists at Mie University used CRISPR-Cas9 gene-editing technology to target and remove the extra copy of chromosome 21 from human cells carrying the genetic condition. But the results were even more interesting. After removing the extra chromosome, researchers observed improvements in gene activity, cell growth, and other signs of cellular health. The biggest catch? This experiment was conducted on cells in a laboratory, NOT in people. It is not yet a treatment or cure for Down syndrome, and major safety challenges remain. Still, this discovery opens an exciting new door in genetic research. Could scientists one day correct chromosome abnormalities at their source?
The Lab Guy retweeted
🚨: Japan trails new drug that regrows human teeth ─ ending dentures and implants forever
The Lab Guy retweeted
7 g de glicina y 7 g de NAC al día durante 16 semanas, y casi todos los marcadores de envejecimiento volvieron a niveles de adulto joven. Es un ensayo pequeño, pero ambos suben el glutatión y cuestan muy poco. Quiero ver réplicas.
Glycine + NAC for aging (fascinating study)
A placebo-controlled trial PMID: 35975308 showed:
16 weeks of glycine + NAC (100mg/kg of each a day, about 7g each for a 70kg person) pushed almost every aging marker measured back toward young adult levels. The placebo group didn't move.
oxidative stress (F2-isoprostanes) -> down 72%, back to the level of the young adults
IL-6 -> down 78%
TNF-alpha -> down 54%
hsCRP -> down 41%
insulin resistance (HOMA-IR) -> 10.8 to 3.9
walking speed -> 1.13 to 1.34 m/s, same as the young adults
grip strength -> up 4kg in both hands
systolic blood pressure -> 132 to 124
waist -> down 3cm
Why it works: glycine and NAC are the two raw materials for glutathione, the body's main antioxidant. Older adults can't make enough of it.
Give the body the parts and it makes its own.
No side effects reported.
The Lab Guy retweeted
So much hype about peptides: heal faster, protect the brain, live longer. But what's the evidence?
In today's new episode of Lifespan, we answer key questions about the science, clinical trial evidence & risks of common & uncommon peptides 💉
Watch now: youtube.com/watch?v=aMb5V6Vk…
The Lab Guy retweeted
Cool
grok bot can now see what's on your phone and answer anything about it
just hold the action button and ask what you need:
> ask anything about the video you're watching
> tell it to build what you saw in a reel for your business
> ask it to break down the article you're reading
it can watch videos, read posts, check the web, basically everything.
i built it as a free iphone shortcut and made it open source, you can grab it below
The Lab Guy retweeted
AI coding agents can be hijacked by a stray file. Forever Security reports an AGENTS.md left in a Downloads folder tricked Codex into installing a malicious npm package. Treat agent instruction files like code: don't run agents in folders with files you didn't write.
The Lab Guy retweeted
The second flying car of the week.
This one is also in early stages: @UtopiaLabs which is in the @fdotinc San Francisco startup factory.
I share these because I just love people who are building things and companies.
And because the FAA has started allowing autonomous flying vehicles so entrepreneurs see a new market coming.
What you building?
The Lab Guy retweeted
We believe voice is the most natural way to interact with intelligence, so we created Dessa, the most authentic full-duplex speech model ever built. Talking with it feels like talking with a person…full of emotion, nuance, pauses, and a natural cadence.
block.xyz/dessa
The Lab Guy retweeted
If we ever meet an alien physicist, I'd quite like to compare the numbers in our textbooks.
The speed of light might look completely different in theirs. Its numerical value depends on the units you choose; physicists sometimes choose units that make it 1.
But a number called the fine-structure constant needs no metres, seconds or kilograms. It measures the strength of electromagnetism, and at low energies it is about 1/137. Do the same experiment under the same conditions, and changing the units won't change that number.
I wonder whether it bothers them too. Or whether that is the first thing they could explain to us.
The Lab Guy retweeted
Mark my words, SpaceX will become the first $10T company, and the first $100T company. 🚀🚀🚀
The Lab Guy retweeted
Research shows a 72-hour fast can completely rebuild your immune system.
A study from the University of Southern California has revealed that fasting for 72 hours can trigger a complete regeneration of the immune system.
Researchers found that prolonged fasting causes the body to deplete its glucose and fat reserves, forcing it into a detoxifying state that eliminates damaged cells and toxins.
When normal eating resumes, stem cells are activated, leading to the production of fresh, healthy white blood cells. This immune reboot effect was observed in both mice and humans, particularly in chemotherapy patients who showed improved immune health after fasting cycles.
Lead researcher Dr. Valter Longo explains that during fasting, a gene called PKA is suppressed—this gene must be turned off for stem cells to enter regenerative mode.
As a result, the immune system essentially clears out older, weaker components and rebuilds itself anew. While more research is needed to explore the full range of benefits across organs, the study suggests that fasting could be a powerful, drug-free strategy for enhancing immunity, especially for those with weakened systems due to aging or cancer treatment.
[Valter Longo. USC Leonard Davis School]
