Physics lab at Berkeley - atom interferometry, electron microscopy, and laser physics for studies from fundamental physics to biology.

Berkeley, CA
Joined September 2012
It won't be long and physics will be overrun by AI slop, mark my words. It's a disaster waiting to happen for academia that has been optimizing for quantity over quality for decades, you can basically see it coming. xitter.cf/getjonwithit/status/19…
I get especially sad when I see researchers at my university, including very senior professors, excitedly saying "Look! Now I can use <random GenAI tool> to read papers, write papers, derive equations, write code, ..." And it's like... why are you even here, man? (1/2)
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Cryo-EM phase-plate images reveal unexpected levels of apparent specimen damage biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Leaving China now after the tomography conference and giving talks. It's very impressive with a lot of smart hard working people doing ambitious science. The infrastructure also strikes as new and well designed, clearly research is the priority here. Wish you all luck 🤞 🥠 🤞
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Direct interaction between a pulsed #laser beam and #ultrafast-timed #electron packets in free space may enhance contrast in #cryoEM and #cryoET The latest cool image of this experiment from @DuXDaniel @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain
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Interesting study using a Fabry-Pérot resonator #laser #PhasePlate for #cryoEM from @TheMuellerLab & Bob Glaeser
Cryo-EM phase-plate images reveal unexpected levels of apparent specimen damage biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Stanley Hall's newest resident has arrived: Theia! The new @thermofisher microscope on the @UCBerkeley campus will be outfitted with the laser phase plate. Thanks to @TheMuellerLab with support from @cziscience!
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Mueller Lab retweeted
Today in #PHY595 #QuantumComputing: The final exam! It's comprehensive but emphasizes the more recent material on quantum protocols and quantum algorithms.
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Mueller Lab retweeted
Working 24 years in cryo-EM now, with an engineering background, it was such a great honor, and fantastic learning experience, visiting Holger’s lab. Greatest most knowledgeable team I’ve ever met!
Laser breadboards are back on the laser phase-contrast microscope
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Replying to @klausenhauser
Apoferritin at 6Å from cryo-Ptychography (Berk Kucukoglu), and at 1.09Å (!!!) from plain cryo-EM (Alex Myasnikov and his amazing team at the DCI-Lausanne.org). Collaboration with Colin Ophus, Carsten Sachse and Knut Müller-Caspary.
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Congratulations to @UCBerkeley astrochemist Jennifer Bergner, winner of this year's Annie Jump Cannon Award in #Astronomy from the #AAS buff.ly/48PXPWM @UCB_Chemistry @AAS_Office
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Our team at #CZImagingInstitute is excited to share the #CryoET Data Portal beta release. With over 13,000 tomograms, it’s the start of what we hope will be a large, open-access portal of high-quality, standardized & annotated cryo-ET data. bit.ly/3T9sZ6D
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In 1937, a Soviet physics genius was fearful of being arrested by the secret police. Lev Landau is a legend of physics. But when some of his friends were arrested by Stalin's NKVD and shot, Landau felt he was next. Landau's strategy for stalling his arrest was to...write a paper. He thought that if he could get famous, he would be able to avoid arrest. He selected one of his many brilliant ideas and worked it out. Landau's idea was that stars possess a neutron core. It was quite similar to the neutron star idea already proposed by Swiss astronomer Fritz Zwicky some years earlier. A neutron star is a celestial object formed almost entirely of neutrons. Neutrons are one of the three components of the atom, but unlike protons or electrons they do not have electrical charge. Also, it is possible for protons and electrons to fuse and form a neutron (and vice versa). As we now know, when stars run out of the nuclear fuel that keeps them burning, they start shrinking under their own gravity. As they get denser and hotter, the conditions are ripe for protons and electrons to fuse and form neutrons. The upshot is stars transforming into a superdense, neutron-rich object. When heavy stars die, this is what they become. Landau's idea was that ordinary stars have at their core a neutron star which helps fuel them. This was suggested as an alternative to the idea that stars draw their fuel from nuclear reactions, an idea which still had not been worked out in detail at the time. Neutron stars, being very dense, can pack a lot of punch gravitationally. A neutron core can accelerate an atom to very high speeds. This kinetic energy converted into heat could fuel a star, Landau showed. Landau thought stars like the Sun could have a neutron core, but it was soon proved to be wrong. At present we do not know any celestial objects that do have neutron cores. But his work helped draw physicists like Oppenheimer into the field, who made important contributions. Landau's paper was published in Nature and made a big splash. Soviet newspapers celebrated his scientific breakthrough. But it was not enough to prevent the NKVD from knocking on his door. The picture below is his mug shot from his arrest. For the story of Landau's arrest, read the wonderful thread by @VergaraLautaro linked below (the mug shot of Landau is also taken from there)
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Mueller Lab retweeted
Very honoured to receive the Stern-Gerlach Medal 2024 from the German Physical Society. Many thanks to my whole team and everybody I have been working together with on this exciting scientific endeavour over the past 25 years. @LMU @MPI_Quantum dpg-physik.de/veroeffentlich…
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Congrats to this year's recipients! Learn more about @PhysicsColumbia's Cory Dean and his plans to break quantum materials free from the periodic table: quantum.columbia.edu/news/br…
🎉 Exciting news! Seven outstanding researchers have been named recipients of the 2023 Brown Investigator Award. This prestigious award recognizes and supports curiosity-driven #basicscience in chemistry and physics. Learn more about the awardees: sciencephilanthropyalliance.…
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In our first faculty focus interview of 2023 we spoke to Holger Müller! He talked about his lab's research, what he wishes someone would ask him about his work, and what he enjoys most about being part of QB3-Berkeley. Read the interview: bit.ly/HolgerMuller
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Mueller Lab retweeted
I have a new vacancy in my team for cryoEM scientist interested in developing cryoFIB milling approaches and cellular cryoET. As always, we will be pushing the boundaries with cryoET #teamtomo. Position is based at Oxford, UK. Please help spread the word. jobs.thermofisher.com/i/glob…
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The Intel 8086 was released in 1978, starting the x86 line that still dominates computing. I'm reverse-engineering the chip by studying the silicon die, and I think I've spotted a bug fix in the silicon. They didn't have microcode updates then so they patched the silicon. 🧵
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