Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) nej.md/4nWaxvM
#ASCO26 | @ASCO

ALT A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.

ALT This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.
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Know your tumor markers for easy points:
AFP → HCC, yolk sac tumor, hepatoblastoma
β-hCG → Choriocarcinoma, testicular germ cell, molar pregnancy
CA-125 → Ovarian cancer
CA 19-9 → Pancreatic cancer
CA 15-3 → Breast cancer
CEA → Colorectal cancer
PSA → Prostate cancer
S-100 → Melanoma, Schwannoma
Chromogranin A → Neuroendocrine tumors
5-HIAA → Carcinoid syndrome (flushing, diarrhea, right-sided heart disease)
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Sites of action of diuretics along the nephron.
bjaed.org/cms/10.1016/j.bjae…
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Pathophysiological interactions between heart and kidney in type 4 cardiorenal syndrome (CRS) or “chronic renocardiac syndrome” (chronic kidney disease [CKD], e.g., chronic glomerular disease, contributing to decreased cardiac function, cardiac hypertrophy, or increased risk of adverse cardiovascular events)
jacc.org/doi/10.1016/j.jacc.…
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Prostatitis is defined as infection, inflammation, or pain of the prostate gland and affects approximately 9.3% of men in their lifetime.
This Review summarizes current evidence on the evaluation and management of prostatitis.
ja.ma/3IvU0yk
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Interpreting an #ECG can seem overwhelming at first, but with a structured approach, it becomes far more manageable.
In this thread, I’ll walk you through how to analyze an ECG like a professional, step by step.
Let’s begin.🧵
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🧵 “ANA Positive ≠ Lupus: The Art of Interpreting Autoantibodies”
ANA positivity is one of the most misunderstood findings in medicine.
Here’s how to approach an ANA report systematically, clinically, and with confidence.
👇 #Rheumatology #ANA #Autoimmunity #MedEd @DrAkhilX @IhabFathiSulima #MedTwitter
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𝐆𝐞𝐧𝐨𝐦𝐞 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 is a hallmark of cancer development and progression characterized by the accumulation of DNA damage; genome instability manifests as increased genetic alteration across the genome, including chromosomal translocations, structural variants, extrachromosomal DNAs, and aneuploidy. Replication stress, frequently observed in rapidly dividing cells, and exogenous factors, such as ultraviolet and ionizing radiation, tobacco smoke, and certain chemicals, can result in genome instability. Early genetic events in the life of cancer cells, such as changes in the maintenance of telomeric length, or the activation of an oncogene can lead to genome instability. Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome.
To learn more about this NEJM Illustrated Glossary term, read the Clinical Implications of Basic Research article “Extrachromosomal DNA — Amping Up Cancer” by Lillian L. Siu, MD (@lillian_siu), and Trevor J. Pugh, PhD (@PughLab), from @UHN and the Ontario Institute for Cancer Research (@oicr_news): nej.md/42jfYdH
Explore more terms: nej.md/glossary
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🔴Blood Gas (ABG) Interpretation and Acid-Base Pathology⤵️ 🔹
#Cardiology #FOAMed #MedEd #medstudent #paramedic #Cardiology #CardioEd #medtwitter #meded #CardioTwitter #cardiotwiteros #MedX #cardiovascular #MedTwitter #medical #medEd #cardiotwitter #medicineball #GDMT #HFrEF
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Schematic Representation of Pathogenesis of 4 Types of Hypersensitivity Reactions
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