@TimonLindeboom

PhD student at the Max Planck Institute of Terrestrial Micriobiology @MaxGENESYS

 Marburg, Germany
schindler-lab.org/
Joined October 2022
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  • Following140
  • Followers126
I'm super excited and grateful-yesterday I was appointed full professor at the Centre for Molecular Biology (ZMBH) at the University of Heidelberg. I am very grateful to my team, colleagues and mentors who have helped me along the way. I very much look forward to the next phase.
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Exciting Opportunity! 📣 The Max Planck Institute for Terrestrial Microbiology is hiring a Head of the DNA Biofoundry. Join us in vibrant #Marburg to develop cutting-edge automation platforms that empower synthetic biology research. 🗓️ Apply by Feb 15, 2025. #ScienceJobs #SynBio
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Congratulations @adanramirezro for finishing your #PhD! It has been a journey. First PhD of the lab #proudPI. Funny enough we dressed inversely. Thanks to the evaluation committee, colleagues and team who made the event unforgettable. Adán even turned into a Macropore sequencer.
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Yesterday I finally had the chance to invite the team for a BBQ again! I am deeply grateful to be able to work with this amazing team! Thank you @adanramirezro @Maria_San_07 @TimonLindeboom @AngelicaMillanA and the X account free members!
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Timon Lindeboom retweeted
Nitin Bohra@nitinbohra312 Jul 2024
I am happy to share that our efforts in @erblabs to integrate metabolism with TXTL to build self sustaining life like systems got one step closer. Now out in @ScienceMagazine 🥳 science.org/doi/10.1126/scie…

Integrated translation and metabolism in a partially self-synthesizing biochemical network

One of the hallmarks of living organisms is their capacity for self-organization and regeneration, which requires a tight integration of metabolic and genetic networks. We sought to construct a...

science.org
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In our recent preprint we describe two plasmid toolboxes. In-Cloning for the generation of scarless TUs and Out-Cloning for acceptor plasmid assembly. Both are compatible with the original MoClo standard. Congratulations to authors Stijn, Tania & Ahmet. biorxiv.org/content/10.1101/…

In- & Out-Cloning: Plasmid toolboxes for scarless transcription unit and modular Golden Gate...

Golden Gate cloning has become one of the most important DNA assembly strategies. The construction of standardized and reusable part libraries, their assembly into transcription units, and the...

biorxiv.org
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Congratulations @TimonLindeboom and @Maria_San_07 who developed a new workflow to identify and select highly SCRaMbLEd synthetic yeast strains. The article just came out in @ACSSynBio. Great collaboration with @LenaHochrein #synbio Find the story here: pubs.acs.org/doi/10.1021/acs…

An Optimized Genotyping Workflow for Identifying Highly SCRaMbLEd Synthetic Yeasts

Abstract. Synthetic Sc2.0 yeast strains contain hundreds to thousands of loxPsym recombination sites that allow restructuring of the Saccharomyces cerevisi

pubs.acs.org
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Back in the lab at 𝗠𝗣𝗜-𝗧𝗠 after an inspiring 3-day scientific retreat full of #science and fun! 🧪✨ Want to join us next time? Visit imprs-marburg.mpg.de/
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Happy to see our Nanopore sequencing workflow for construct validation published. Congratulations @adanramirezro, @CedKB and the one and only Tania pubs.acs.org/doi/10.1021/acs… Big thanks @MPDL for funding Open Access. We also pulled together a protocol doi.org/10.48550/arXiv.2401.…

DuBA.flowA Low-Cost, Long-Read Amplicon Sequencing Workflow for the Validation of Synthetic DNA...

Abstract. Modern biological science, especially synthetic biology, relies heavily on the construction of DNA elements, often in the form of plasmids. Plasm

pubs.acs.org
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Timon Lindeboom retweeted
Cell Press@CellPressNews8 Nov 2023
#Yeast cell created with an over 50% synthetic #genome can survive and replicate similar to wild type. See below a collection of papers presenting this half-synthetic yeast and showcasing the #SyntheticYeastGenomeProject (Sc2.0) @yeastgenome 🧵
Scanning electron micrographs of the syn6.5 strain of yeast which has ~31% synthetic DNA and displays normal morphology and budding behavior. Cell, Zhao et al.

ALT Scanning electron micrographs of the syn6.5 strain of yeast which has ~31% synthetic DNA and displays normal morphology and budding behavior. Cell, Zhao et al.

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I am excited to announce the tRNA neochromosome project is finally published at @CellCellPress. @SynbioRoy shared first coauthor, @caiyizhi and all collaboration partners made a massive effort to finally get the story out thank you! Find the article here: authors.elsevier.com/sd/arti…
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Inspired by our first paper about synthetic sRNAs we looked into predicting optimal seed sequences for sRNAs. The story is finally out doi.org/10.1093/bioinformati…. Fruitful collaboration with @BorkBerghoff. First purely computational paper of the lab and first paper of @CedKB!

DIGGER-Bac: prediction of seed regions for high-fidelity construction of synthetic small RNAs in...

Summary. Synthetic small RNAs (sRNAs) are gaining increasing attention in the field of synthetic biology and bioengineering for efficient post-transcriptio

academic.oup.com
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Timon Lindeboom retweeted
Elisabeth Bobkova@bobelly_14 Feb 2023
I am excited to see the project I have been working on during my master thesis under the guidance of @KaiRiedmiller and Patrick Reiser finally out. Thanks to @graeter_mbm and @P_Friederich for the great time and excellent mentoring!
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#MPITMTour: How to use #automation to scale-up and scale-down at the same time? @DSchindler_PDR team is building #synthetic genomes for #microbiology! They've also established the MaxGENESYS #biofoundry for #bioengineering. More: mpi-marburg.mpg.de/927564/ma…; schindler-lab.org/
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L-SCRaMbLE creates large-scale genome rearrangements in synthetic Sc2.0 chromosomes ift.tt/hMi7LZb #biorxiv_synbio
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Excited to share our first #preprint with #synthetic yeast. Great collaboration with @LenaHochrein showing for the first time that L-SCRaMbLE is active on chromosome scale! biorxiv.org/content/10.1101/… work by talented students @TimonLindeboom @Maria_San_07 @CedKB @adanramirezro

L-SCRaMbLE creates large-scale genome rearrangements in synthetic Sc2.0 chromosomes

Optimization of the metabolic flux through heterologous pathways to improve bioproduction or utilization of alternative substrates requires both fine-tuning of non-native gene expression levels and...

biorxiv.org
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Timon Lindeboom retweeted
SYBORG@erblabs18 Nov 2022
Super nice special about #synbio featuring @DSchindler_PDR and MaxGENESYS @mpi_marburg and @SYNMIKRO in November issue of @Lab_Journal (German only...)
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