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Thomas Cardaci (@TomCardaci) profile picture

Thomas Cardaci

@TomCardaci

Research Fellow, Postdoc | PhD, MS, CSCS*D | Cancer, Muscle Biology, & Exercise | Colorado State University | CU Anschutz SOM | USC SOM, Rutgers & Baylor Alumni

 Fort Collins, CO
Joined July 2013
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Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)Photo by Thomas Cardaci (@TomCardaci)
Decellularized some muscle for SEM analysis of the extracellular matrix. I think it came out pretty sick!! #myotwitter – at South Carolina, USA
Image from Thomas Cardaci (@TomCardaci)
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Thomas Cardaci retweeted
AJP-Cell Physiology (@AJPCellPhys) profile picture
AJP-Cell Physiology@AJPCellPhysNov 3
New #cancer research from @UofSC, Decreased skeletal #muscle intramyocellular #lipid droplet-mitochondrial contact contributes to #myosteatosis in cancer #cachexia (Thomas D. Cardaci et al.): ow.ly/Saex5102UHR
Image from AJP-Cell Physiology (@AJPCellPhys)
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Excited to share our recent paper “Pro-Fibrotic Immune Cells & FAPs Contribute to Skeletal Muscle ECM Remodeling and Fibrosis in Cancer Cachexia” 🧵 Summary of our findings below. 👇 journals.physiology.org/doi/… @b_veen17 @UofSCSOMC @UofSC @AJPCellPhys @USCResearch #myotwitter
Profibrotic immune cells and fibro-adipogenic progenitors contribute to skeletal muscle extracell...

Profibrotic immune cells and fibro-adipogenic progenitors contribute to skeletal muscle extracell...

Cachexia, the loss of skeletal muscle mass and function with cancer, contributes to reduced life quality and worsened survival. Skeletal muscle fibrosis leads to disproportionate muscle weakness;...

journals.physiology.org
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6️⃣ Gene expression analysis further supports this profibrotic and altered immune microenvironment: ⬆️ TGF-β, HIF-1α, IL-6, Nos2 ⬆️ Collagens (Col1, Col5), Fn1, MMP2 ➡️ Cachectic muscle = active fibrogenic + inflammatory signaling.
Image from Thomas Cardaci (@TomCardaci)
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7️⃣ 🧩 Take-home: Muscle fibrosis is not a consequence of tumor presence but a distinct pathological feature of cancer cachexia. Cachexia promotes a profibrotic microenvironment, where immune cells + FAPs contribute to ECM remodeling and worsen muscle dysfunction beyond atrophy.
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There's new #fibrosis info in this #ArticleinPress, Pro-Fibrotic Immune Cells and Fibro-Adipogenic Progenitors Contribute to Skeletal Muscle Extracellular Matrix Remodeling and Fibrosis in Cancer Cachexia (Thomas D. Cardaci et al. @UofSCSOMC): ow.ly/Ku2N50X72JL
Image from AJP-Cell Physiology (@AJPCellPhys)
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From talented teams at @UofU3i and @UofUPT comes today's impressive #ArticleinPress. #Macrophage Immunometabolism - Emerging Targets for Regrowth in #Aging #Muscle (Zachary Fennel et al.): ow.ly/R2iv50UPCew
Image from AJP-Endocrinology and Metabolism (@AJPEndoMetab)
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New graphical review now published! 🚨 Mechanistic Insight into Physical Activity Pleiotropy in Cancer Prevention Read it here: brnw.ch/21wNIRV #Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #CancerPrevention
Mechanistic Insight into Physical Activity... : Exercise, Sport and Movement

Mechanistic Insight into Physical Activity... : Exercise, Sport and Movement

Although improvements in prevention and screening have curbed the incidence of some cancers, the global burden of cancer is substantial and continues...

ovid.com
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New Article Alert! ✨ Multisymptom Burden in Cancer Survivors: Benefits of Physical Activity Find it here: brnw.ch/21wNNp2 #Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #Cancer
Multisymptom Burden in Cancer Survivors: Benefits... : Exercise, Sport and Movement

Multisymptom Burden in Cancer Survivors: Benefits... : Exercise, Sport and Movement

In contrast with other leading causes of mortality, the cancer death rate in the United States continues to decline, reflecting improvements in...

ovid.com
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The wide-ranging benefits of #PhysicalActivity and structured exercise offer a strong case for their role in reducing the negative effects of cancer and its treatments. Learn more: brnw.ch/21wP6fW #Exercise #Sport #Movement #ExerciseOncology #Cancer
Multisymptom Burden in Cancer Survivors: Benefits... : Exercise, Sport and Movement

Multisymptom Burden in Cancer Survivors: Benefits... : Exercise, Sport and Movement

In contrast with other leading causes of mortality, the cancer death rate in the United States continues to decline, reflecting improvements in...

ovid.com
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Thomas Cardaci retweeted
Dr Ai Lyn Tan (@DrAiLynTan) profile picture
Dr Ai Lyn Tan@DrAiLynTan3 Jan 2025
#PhysicalActivity #exercise can reduce #cancer risk ✅Control weight ✅Improve immune & inflammatory profile ✅Enhance colonic environment ✅Regulate sex hormone levels 👉🏽journals.lww.com/acsm-esm/fu… via @ESM_ACSM
Image from Dr Ai Lyn Tan (@DrAiLynTan)
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New paper from the lab reviewing ‘Diversity in Chemotherapy-Induced Cachexia’ @ljnovinger | American Journal of Physiology-Cell Physiology journals.physiology.org/doi/…
Diversity in chemotherapy-induced cachexia | American Journal of Physiology-Cell Physiology |...

Diversity in chemotherapy-induced cachexia | American Journal of Physiology-Cell Physiology |...

Preclinical and clinical studies suggest that chronic administration of cytotoxic drugs (e.g., chemotherapy) may contribute to the occurrence of skeletal muscle wasting and weakness/fatigue (i.e.,...

journals.physiology.org
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🚨🚨I’ll be speaking at the ISSN Tactical Summit on November 2, 2024 organized by @FireRescueWell and Drew Gonzalez There is a fantastic line up of speakers, to include @drmyohead, @AJagim, @BM_Roberts_SkM, @DrJayDawes, @DrBobLockie, @DrCreatine, @FittoEnforcecom
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Today's #ArticleinPress is an APS Select article! Decreased skeletal muscle intramyocellular #lipid droplet-mitochondrial contact contributes to myosteatosis in #cancer cachexia (Thomas Cardaci et al. @UofSC): ow.ly/TzJC50Toqb7
Image from AJP-Cell Physiology (@AJPCellPhys)
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Congratulations! Thank you @TomCardaci for publishing with #AJPCell!
APS Publications (@APSPublications) profile pictureAPS Publications@APSPublications6 Sep 2024
Congrats to Thomas D. Cardaci et al. for the #APSselect paper "Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia" in @ajpcellphys @TomCardaci @UofSCSOMC ow.ly/6pEq50ThzMG
Image from APS Publications (@APSPublications)
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What a great way to end the week! Thanks for selecting our paper as an #APSselect paper! – at South Carolina, USA
APS Publications (@APSPublications) profile pictureAPS Publications@APSPublications6 Sep 2024
Congrats to Thomas D. Cardaci et al. for the #APSselect paper "Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia" in @ajpcellphys @TomCardaci @UofSCSOMC ow.ly/6pEq50ThzMG
Image from APS Publications (@APSPublications)
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