@mathonco postdoc with a wet lab background and expertise in single-cell biology. Cancer Evo, cell plasticity, genotype-phenotype map.
Joined October 2020
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Stoked to see our paper out today in @NatureCancer! Epigenetic cell state, not genetic variegation, is the principal substrate for bottleneck selection during induction chemotherapy in childhood BCP-ALL. Check it out here rdcu.be/cnL8X
@uclcancer
Virginia Turati retweeted
Some academic tools that I discovered recently for research students. Also, attaching two of my previous lists too!
A 🪡
@OpenAcademics @ThePhDPlace #AcademicTwitter #AcademicChatter #scicomm #STEM
Virginia Turati retweeted
I’m excited to share our recently published manuscript in PNAS on clonal dynamics in the homeostatic epidermis. This paper took a winding course and was the first project that was incorporated into my DPhil. 1/🧵
Virginia Turati retweeted
Fresh preprint! In this work, we study the dynamics of metastatic disease, i.e. changes in the collective systemic burden and in the individual metastases, over cycles of adaptive therapy to infer underlying disease characteristics.
Excited to share our #AndersonLab latest preprint led by @jillagal with help from @StroblMAR @mathoncbro @markrt_ #Gatenby & Jingsong Zhang on, The sum and the parts: dynamics of multiple and individual metastases during adaptive therapy @EvolTherapy biorxiv.org/content/10.1101/…
Virginia Turati retweeted
Happy to share the latest #AndersonLab tool developed by @sandhya212 Mistic: An open-source multiplexed image t-SNE viewer, cell.com/patterns/fulltext/S… with help from @cgatenbee, @markrt_ & many more! Our 1st publication in @CellPressNews Patterns. – at Hawaii, USA
Virginia Turati retweeted
Just sent out #MathOnco newsletter issue 216:
-evolutionary game theory
-continuum resistance
-reaction-diffusion
-stochastic control
-clinical translation
Artwork: @TuratiVirginia 💯
Virginia Turati retweeted
“Already, the United States claims the highest rate of maternal and infant mortality among wealthy nations. Should the court overturn Roe v. Wade, these grim statistics will only get worse,” argued a Nature editorial last month go.nature.com/3QNIrli
Virginia Turati retweeted
Just our in @NatureBiotech a cool collaboration with @trevoragraham & Darryl Shibata led by @CalumGabbutt with help from @research_junkie & @markrt_ Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues go.nature.com/3sTqOa8 – at Tampa, FL
Virginia Turati retweeted
Pleased to announce the release of #AndersonLab latest tool: GATTACA, for base pair resolution mutation tracking in agent-based models like @HybridAutomata. Developed by @research_junkie for our somatic evolution studies. Here’s a cool gif! biorxiv.org/content/10.1101/… – at Tampa, FL
Virginia Turati retweeted
Excited to share our latest tool, #VALIS Virtual Alignment of pathoLogy Image Series - it’s been years in the making by the talented @cgatenbee! It automatically aligns serial image slices from immunohistochemistry, immunofluorescence & much more. Here’s a cool gif! #AndersonLab
Virginia Turati retweeted
Pleased to share our 1st #AndersonLab imaging focussed tool, Mistic: an open-source multiplexed image t-SNE viewer developed by @sandhya212 with help from @cgatenbee @markrt_ & @mathoncbro doi.org/10.1101/2021.10.08.4… – at Tampa, FL
Nice to see our work describing the relative contribution of different sources of intratumor heterogeneity to #chemoresistance in BCP-ALL featured in the Research Watch section of
@CD_AACR 👇
cancerdiscovery.aacrjournals…
For the original paper
@NatureCancer rdcu.be/cnL8X
Virginia Turati retweeted
In our latest @NatureCancer paper (rdcu.be/cnL8X), we use different technologies to interrogate BCP-ALL resistant cells, including mFISH, qPCR, bulk RNA, scRNA, low-pass scWGS and DNA methylation arrays on diagnosis, MRD, relapse, PDXs and control chord blood
1/7
Virginia Turati retweeted
Huge collab driven by @TuratiVirginia and the Enver lab providing one of the better proofs I’ve seen so far that preexisting epigenetic cell states are selected for during chemotherapy. Congrats all!
Stoked to see our paper out today in @NatureCancer! Epigenetic cell state, not genetic variegation, is the principal substrate for bottleneck selection during induction chemotherapy in childhood BCP-ALL. Check it out here rdcu.be/cnL8X
@uclcancer
Virginia Turati retweeted
⭐️ONLINE NOW @NatureCancer: "#Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic #leukemia" by @TuratiVirginia @tariqenver &Co @UCL
Find it here!👇
go.nature.com/3hHKW8a
rdcu.be/cnUJc
#CancerTherapy #Chemoresistance
A fun journey alongside wonderful collaborators. Nicola Potter @JavierHerrero7, @VanLooLab, @generoom, @SimoneEcker, @AfonsoHenriques, @ChulingD, SE. Jacobsen and Mel Greaves, amongst many others!
Virginia Turati retweeted
This week in #MathOnco 168: Artistoo, personalized immunotherapy, single-cell, collective migration, and (finally) math onco conferences!
thisweekmathonco.substack.co…
Cover design by @inge_wortel, designed using #Artistoo.
