@WardGroupBS

Artificial Metalloenzymes Laboratory at @UniBasel_en led by Prof. Thomas R. Ward.

 Basel, Switzerland
ward.chemie.unibas.ch/
Joined November 2017
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  • Following188
  • Followers1.4K
47Media
Understatement of the year...
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Large-scale, automated screening and active machine learning can increase the success rate and efficiency of enzyme engineering NEW #ASAP by @JeschekLab, @arkrause, @WardGroupBS & colleagues Read it here: go.acs.org/a28
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Now online: News & Views on the Article by Zhi Zou, Thomas R. Ward & co-workers @WardGroupBS @UniBasel_en nature.com/articles/s44160-0… ($) Microbial cell factories for cycloalkene synthesis by Ru Jiang & Gerard Roelfes @RoelfesGroup nature.com/articles/s44160-0… ($)

Combining an artificial metathase with a fatty acid decarboxylase in a whole cell for cycloalkene...

Nature Synthesis - Artificial metalloenzymes are useful catalysts in synthesis, but their use in cells is a challenge. Now, the development of an engineered whole-cell enzymatic cascade, which...

nature.com
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Nice work! ✨ nature.com/articles/s41557-0… – at Pully, Suisse

Photoredox-active Cr(0) luminophores featuring photophysical properties competitive with Ru(II) and...

Nature Chemistry - Although noble metal coordination complexes typically show promising photophysical properties that enable applications in lighting, photocatalysis and solar energy conversion,...

nature.com
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ever since @barra_lena's work on PLP-mediated catalysis in the biosynthesis of altemicidin, I've been fascinated by PLP. very cool to see this enzymatic pathway intercepted by photoredox-generated radicals!
Yang Yang@yang2biocat27 Jul 2023
We published our first paper on pyridoxal radical biocatalysis in @ScienceMagazine : lnkd.in/gkB5dpKM. What we are most excited about is the ability to design general biocatalytic activation modes which are both new-to-biology and new-to-chemistry:
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Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)–H Bonds | JACS @UniBasel_en @WardGroupBS @TotalSyntheses #Metalloenzyme #Enantioselective #Amidation #Nitrene #CHfunctionalization pubs.acs.org/doi/10.1021/jac…

Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated...

Abstract. Enantioselective C–H amidation offers attractive means to assemble C–N bonds to synthesize high-added value, nitrogen-containing molecules. In re

pubs.acs.org
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Celebrating Rudy Marcus’ 100th birthday ⁦@Caltech⁩ ⁦@CaltechCCE⁩ ⁦@NobelPrize⁩ . Still loving #chemistry!!
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We are thrilled to share a new HF-free technology that converts fluorspar to fluorochemicals. Enormous congratulations to the amazing team of chemists who made this recurring dream a reality! science.org/doi/10.1126/scie… @CalumPatel @ScienceMagazine @OxfordChemistry @Fluo_Rok
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This @ACSChemRev was guest edited by #NCCRCatalysis PIs Thomas @WardGroupBS and Christophe @CoperetGroup! The issue focuses on "Bridging the gaps: Learning from Catalysis across Boundaries" - right up our alley! 🧪📑 Read here 👉🏻 doi.org/10.1021/acs.chemrev.… xitter.cf/CoperetGroup/status/16…

Introduction: Bridging the Gaps: Learning from Catalysis across Boundaries

Catalysis is a central science that will have a key contribution to the development of more sustainable processes, in connection with the current emerging

pubs.acs.org
Copéret Group / @coperetgroup.bsky.social@CoperetGroup11 May 2023
Bridging the Gaps: Learning from Catalysis across Boundaries @NCCR_Catalysis @WardGroupBS pubs.acs.org/doi/10.1021/acs…
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JACS online: An Artificial #Metalloenzyme Based on a #Copper #Heteroscorpionate Enables sp3 C–H #Functionalization via #Intramolecular #Carbene Insertion @UniBasel_en @WardGroupBS @TotalSynthesis @J_A_C_S @isciverse @CHNSci @TotalSyntheses pubs.acs.org/doi/10.1021/jac…

An Artificial Metalloenzyme Based on a Copper Heteroscorpionate Enables sp3 C–H Functionalization...

Abstract. The selective functionalization of sp3 C–H bonds is a versatile tool for the diversification of organic compounds. Combining attractive features

pubs.acs.org
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It's my great pleasure to announce that I'm going to start a professorship and research group in Synthetic Microbiology at the University of Regensburg as of this summer. After an exciting 10+ years in the @BPL_ethz at @ETH_BSSE it's time for new adventures! 🧬🧫🔬💻
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We reconstitute active artificial hydrogenases using apo-protein of [Fe]-hydrogenase and synthetic Mn complexes. The most active variants appear to operate via a reaction pathway deviated from the native pathway. onlinelibrary.wiley.com/doi/… @EPFL_CHEM_Tweet @angew_chem
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Metal hydride reductions join the growing family of reactions catalyzed by metalloenzymes! Check out this paper on abiotic reactivity, achieved on a carbonic anhydrase platform. Kudos to @Jipengfeium, Jeeyoung, and Yang! nature.com/articles/s41557-0…
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Ward Group retweeted
D-CHAB@ETH_DCHAB3 Feb 2021
For 22 years, Antonio Togni has been successful in research @ETH_en and was very committed to teaching & doctoral studies. Now he is retiring. A review. chab.ethz.ch/en/news-and-eve…

A good nose for the essence

A coincidence led him to industry, a coincidence back to university. In both cases, however, Antonio Togni owes his success mainly to his good instinct for research topics and mentors. Now he is...

chab.ethz.ch
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Clariant signs catalysis research partnership with ETH Zurich. A new opportunity for students! pressreleasefinder.com/Clari…

Clariant signs catalysis research partnership with prestigious ETH Zurich university

Clariant, a focused, sustainable and innovative specialty chemical company, has signed a cooperation agreement with ETH Zurich to support research in catalysis and sustainable chemistry with a...

pressreleasefinder.com
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Thrilled to share some of our newest work on non-natural biocatalysis featuring artificial gold enzymes and AI-enabled engineering. Great work by @t_vornholt 👏 in collaboration with @WardGroupBS 🙌! advances.sciencemag.org/cont…
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New preprint @LabNikel📢Lorena Fernández & @AntoninCros2 @DTUBiosustain engineered a set of easy-to-cure #plasmids carrying mutator alleles to enable spatiotemporal control of DNA mutagenesis rates in #Pseudomonas & other bacteria #SynBio @biorxivpreprint biorxiv.org/content/10.1101/…

Spatiotemporal manipulation of the mismatch repair system of Pseudomonas putida accelerates...

Developing complex phenotypes in industrially-relevant bacteria is a major goal of metabolic engineering, which encompasses the implementation of both rational and random approaches. In the latter...

biorxiv.org
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We are honored to announce the next GRC Connects on “Innovation by Evolution” featuring Nobel laureate, Dr. @francesarnold and Dr. Donald Hilvert. Please join us for their scientific talks followed by Q&A. Register here for this free event: grc.org/grc-connects-innovat…
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Who doesn't love a wobbly alcohol #enzyme moment at Christmas #Labvent 🧪💚🎄
UoNSPT@UoNSPT17 Dec 2020
Our favourite festive #enzyme - alcohol dehydrogenase (one of the >2500 enzymes in our cells) makes its second appearance this #Labvent by @APordea #alcoholdehydrogenase @BiochemSoc @The_Biochemist
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Replying to @angew_chem @Pacifichem
Oh yes.... we should be there 😢
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