@WeiFDU

Professor at Fudan University, working on neuroimaging and brain disorders.

wchenglab.com/
Joined March 2018
  • Tweets2.1K
  • Following448
  • Followers444
2Media
New online! UK Biobank at 20 — a growing, global resource for dementia research dlvr.it/TS2X6D
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Jingnan Du
@jingnandu049Feb 12
I am thrilled to share that I’ll be joining the University of Notre Dame (@NotreDame) as an Assistant Professor of Psychology this July!☘️🧠 Please reach out if you're interested in joining my lab! More details to follow soon.
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Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression patterns alz-journals.onlinelibrary.w…

Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression...

INTRODUCTION Alzheimer's disease (AD) shows marked molecular heterogeneity. Defining biological subtypes may refine diagnosis and treatment. METHODS We analyzed cerebrospinal fluid (CSF) proteomics...

alz-journals.onlinelibrary.wiley.com
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Hesheng Liu@hesheng3Feb 4
2/7 Using a large (n = 863), multimodal, multi-intervention clinical imaging dataset, we applied precision functional mapping and found that key subcortical nuclei in Parkinson’s disease—including the SN, STN, VIM/CM, GPi, GPe, and putamen—are preferentially linked to the SCAN.
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Most blood proteomics analyses of human disease focus on a single disease endpoint missing assessment of specificity. This analysis of 8,262 individuals across 59 diseases offers an atlas of Olink proteomic signatures across the disease spectrum.
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Mapping the plasma metabolome to human health and disease in 274,241 adults go.nature.com/4mmToc0

Mapping the plasma metabolome to human health and disease in 274,241 adults

Nature Metabolism - Using data from the UK Biobank, the authors develop a comprehensive human metabolome–phenome atlas, including a browsable web tool, to uncover unique...

nature.com
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In this study, Chen et al. use UK Biobank data to reveal a dietary pattern associated with a lower risk of dementia, and validate this in additional cohorts. nature.com/articles/s41562-0…

Machine learning-assisted optimization of dietary intervention against dementia risk

Nature Human Behaviour - Chen et al. use UK Biobank data to reveal a dietary pattern associated with a lower risk of dementia, and validate this in additional cohorts.

nature.com
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Now online - - had great fun thinking about this with colleagues from Shanghai! nature.com/articles/s44220-0… "brain-based heterogeneity is not a static feature; it is more pronounced at the onset of the disorder but reduced over the long term"

Gray matter volume heterogeneity by stage, site of origin and pathophysiology in schizophrenia

Nature Mental Health - Schizophrenia exhibits significant variability in brain structures, traditionally viewed as static due to heterogeneous subgroups. Here the authors use magnetic resonance...

nature.com
Lena K. Palaniyappan@lena_pl25 May 2024
Heterogeneity appears to be mutable and 'front-loaded' in the course of schizophrenia; anatomical variability is high early on, but converges to be more predictable in the established phase medrxiv.org/content/10.1101/…

Brain heterogeneity in 1,792 individuals with schizophrenia: effects of illness stage, sites of...

Importance Schizophrenia is characterized with greater variability beyond the mean differences in brain structures. This variability is often assumed to be static, reflecting the presence of hetero...

medrxiv.org
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Overall, another great paper from the Alkes group at @HarvardChanSPH. Here are some of the co-authors I could find on twitter: @BennyStrobes @GaspardKerner @JohnNDanesh @WeiFDU @xilin_jiang Link to pre-print: medrxiv.org/content/10.1101/…

Pleiotropic heritability quantifies the shared genetic variance of common diseases

Common diseases are highly pleiotropic, but the overall contribution of pleiotropy to a target disease’s architecture is unknown, as most studies focus on genetic correlations with each auxiliary...

medrxiv.org
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Our new study with Fudan University: Adolescents who sleep longer perform better at cognitive tasks | University of Cambridge ⁦@WeiFDU⁩ cam.ac.uk/research/news/adol…

Adolescents who sleep longer perform better at cognitive tasks

But the study of adolescents in the US also showed that even those with better sleeping habits were not reaching the amount of sleep recommended for their age group. Sleep plays an important role in...

cam.ac.uk
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Towards individualized #precisionmedicine and prediction of risk and treatment responses #heartdisease @uk_biobank @NatureMedicine nature.com/articles/s41591-0…

Meta-prediction of coronary artery disease risk

Nature Medicine - A meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors, such as laboratory tests and baseline diagnoses, had superior...

nature.com
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Up to 85% of people living with #dementia may not receive post-diagnosis care alzint.org/news-events/news/… via @AlzDisInt #Alzheimers
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In response to a recent Guardian article about why approved researchers in China can access our data, we've provided some additional information for our participants, including how we follow Government guidance on who can use UK Biobank. Please read: ow.ly/m4x050VAIzp
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Interesting reads on genetics, omics, & precision medicine from this week👇 1⃣A distribution atlas of the human proteome There is constant influx and efflux of proteins between the plasma and surrounding organs and cells. Applying proteomics in 18 organs & 8 blood cell types and integrating it with existing RNA/protein atlases, this study maps the tissue/cell origin of each plasma protein! 👉A foundational resource for discovering specific circulating signatures of organ pathologies. 🔗cell.com/cell/fulltext/S0092…
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Metabolite signatures of chronological age, aging, survival, and longevity cell.com/cell-reports/fullte…
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Our April issue is now live! nature.com/neuro/volumes/28/…
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👉Using data from the UK Biobank, the authors investigate the differences between short and long #sleep duration regarding genetics, biomarkers and phenotypic implications. ⁦@Jianfengfenguk, @WeiFDU nature.com/articles/s44220-0…

Divergent biological pathways linking short and long sleep durations to mental and physical health

Nature Mental Health - Using data from the UK Biobank, the authors investigate the differences between short and long sleep duration regarding genetics, biomarkers and phenotypic implications.

nature.com
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Wei Cheng retweeted
COPSS@COPSSNews7 Mar 2025
Finally, our winner for the 2025 George W. Snedecor Award is Hongtu Zhu! 🎉🎉🎉
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Divergent biological pathways linking short and long sleep durations to mental and physical health | Nature Mental Health ⁦@Jianfengfenguk⁩ ⁦@WeiFDU⁩ ⁦@psychiatry_ucam⁩ ⁦@Nature⁩ nature.com/articles/s44220-0…
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How do you get to the nitty-gritty of Parkinson's disease? Do high-throughput proteomics. nature.com/articles/s43587-0…

Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological...

Nature Aging - The early pathophysiology of Parkinson’s disease is not well understood. Here the authors perform large-scale proteomic analyses of incident Parkinson’s disease to reveal...

nature.com
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