Celebrating our recent JEM paper and Laura's PhD with nice Italian food😀

Congrats, Laura, and all the best for your (bright) future!

Very happy to see my PhD student Laura Bub defend her thesis yesterday 😀 Great discussion with opponent Sylvia Knapp from Vienna.

Interested in immunometabolism of macrophages and metabolic crosstalk in the lung? Read my review just published in @MucosalImmunol: doi.org/10.1016/j.mucimm.202…

Great collaboration with the labs of @bart_lambrecht and @gigaipl

Congratulations to PhD student @laura_bub_ and other members of my lab who contributed to the study.

(3) Our study provides a mechanism of how the loss of tissue-resident macrophages is sensed and establishes the new concept that metabolic cues from the tissue microenvironment instruct the differentiation of recruited monocytes into lung macrophages.

(2) We found that fibroblasts produce 7alpha,25-dihydroxycholesterol in response to resident macrophage depletion, which recruits monocytes via the oxysterol receptor GPR183 to replenish macrophage niches in the lung.

(1) We used single-cell RNA-sequencing and new macrophage depletion models to identify niche-derived signals that promote monocyte-derived macrophages.

We discovered that cholesterol metabolites (oxysterols) recognized by the receptor GPR183 attract monocytes to repopulate depleted lung macrophage niches.

Happy to see our paper published in JEM: doi.org/10.1084/jem.20252667

It was fun to reconnect with old friends and colleagues at Yale 😀😎

Amazing how Richard is still going strong!

It was great to present our latest work on lung macrophages at the Richard Flavell Symposium.

Submit your abstract for EMIG 2025 at emig2025.de/ Deadline is 30 April.

Very proud see former PhD student @elzaevren at the Conferment Ceremony @karolinskainst

Lots of interesting scientific discussions with engaged students 😀